中国组织工程研究

中国组织工程研究 ›› 2021, Vol. 25 ›› Issue (22): 3603-3608.doi: 10.3969/j.issn.2095-4344.3175

• 生物材料综述 biomaterial review • 上一篇    

高分子聚合物聚醚酮酮的发展及其医学应用前景

闻志靖1，顾鹏真1，贺西京1，2，李家良1，王一斌1，王逸群1   

  1. 1西安交通大学第二附属医院骨科，陕西省西安市  710004；2西安国际医学中心医院，陕西省西安市  710100
  • 收稿日期:2020-06-18 修回日期:2020-06-24 接受日期:2020-07-29 出版日期:2021-08-08 发布日期:2021-01-21
  • 通讯作者: 贺西京，博士，教授，博士生导师，主任医师，西安交通大学第二附属医院骨科，陕西省西安市 710004；西安国际医学中心医院，陕西省西安市 710100
  • 作者简介:闻志靖，男，1993年生，安徽省合肥市人，汉族，西安交通大学在读博士，主要从事脊柱外科研究。
  • 基金资助:
    基金资助：中央高校建设世界一流大学(学科)和特色发展引导专项资金(PY3A023)，项目负责人：贺西京

Development of high molecular polymer polyetherketoneketone and its prospects in medical applications

Wen Zhijing1, Gu Pengzhen1, He Xijing1, 2, Li Jialiang1, Wang Yibin1, Wang Yiqun1   

  1. 1Department of Orthopedics, The Second Affiliated Hospital of Xi’an Jiaotong University, Xi’an 710004, Shaanxi Province, China; 2Xi’an International Medical Center Hospital, Xi’an 710100, Shaanxi Province, China
  • Received:2020-06-18 Revised:2020-06-24 Accepted:2020-07-29 Online:2021-08-08 Published:2021-01-21
  • Contact: He Xijing, MD, PhD, Professor, Doctoral supervisor, Chief physician, Department of Orthopedics, The Second Affiliated Hospital of Xi’an Jiaotong University, Xi’an 710004, Shaanxi Province, China; Xi’an International Medical Center Hospital, Xi’an 710100, Shaanxi Province, China
  • About author:Wen Zhijing, Doctoral candidate, Department of Orthopedics, The Second Affiliated Hospital of Xi’an Jiaotong University, Xi’an 710004, Shaanxi Province, China
  • Supported by:
    the World-Class Universities (Disciplines) and the Characteristic Development Guidance Funds for the Central Universities, No. PY3A023 (to HXJ)

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摘要：

文题释义：
聚醚酮酮：是在主链结构中含有两个酮键和一个醚键的重复单元所构成的高分子聚合物，属特种高分子材料，具有良好的高温稳定性、抗辐射能力及耐化学腐蚀能力等，是一种广泛用于航空航天、汽车制造业、电子电器等领域的新型材料。近年来由于其良好的生物相容性，是一种能广泛应用于骨科、口腔颌面外科等生物医学领域的新型生物材料。

背景：聚醚酮酮具有优良的生物相容性，被广泛用于脊柱、关节及口腔颌面外科等生物医学领域中。
目的：归纳和总结目前聚醚酮酮的合成及其在医学应用方面的研究进展。
方法：检索PubMed、Web of Science和CNKI数据库等收录的有关聚醚酮酮合成发展及其在生物医学领域中应用的文章，英文检索词为“polyetherketoneketone，synthesis，scaffold material，implant，tissue engineering，biocompatibility”，中文检索词为“聚醚酮酮，合成，支架材料，植入物，组织工程，生物相容性”。根据纳入与排除标准对所有文章进行初筛后，保留相关性较高的文章进行综述。
结果与结论：近年来随着医工结合的兴起，聚醚酮酮及其复合物逐渐应用到骨科、口腔颌面外科等生物医学领域。在骨科方面，经过不同物理化学改性的聚醚酮酮及其复合物不仅可以保持与人体骨骼相似的弹性模量、提升硬度，还可以改善其生物相容性、增加其抑菌性能、促进骨整合等。在口腔颌面外科方面，可用作种植牙基体、框架、可摘局部义齿的卡环等，聚醚酮酮不仅可以保持良好的美学优势，同时可以拥有良好的抗疲劳性及保持力，与口腔内的黏合系统能保证充分的黏合能力，因此聚醚酮酮作为口腔科修复材料的应用潜力巨大。对聚醚酮酮的改性及其复合物更深层次的研究仍然是一大热点，通过不断提升材料的性能，进行更多的体内外实验来证实聚醚酮酮作为骨科及口腔颌面外科植入物材料的优越性，进行临床转化，将会拥有更好的前景。

关键词: 骨, 材料, 聚醚酮酮, 植入物, 支架材料, 生物相容性, 组织工程, 研究进展, 综述

Abstract: BACKGROUND: Polyetherketoneketone has excellent biocompatibility and is widely used in biomedical fields such as spine, joint and oral and maxillofacial surgery.
OBJECTIVE: To summarize the synthesis of polyetherketoneketone and its research progress in medical applications.
METHODS: PubMed, Web of Science and CNKI databases were searched for the articles concerning about the synthesis and development of polyetherketoneketone and their applications in the field of biomedicine with the search terms of “polyetherketoneketone, synthesis, scaffold material, implant, tissue engineering, biocompatibility” in English and Chinese, respectively. After initial screening of all articles according to inclusion and exclusion criteria, articles with higher relevance were included for review.
RESULTS AND CONCLUSION: In recent years, with the rise of the combination of medical and engineering, polyetherketoneketone and its composites have been gradually applied to the fields of orthopedics, oral and maxillofacial surgery. In orthopedics, polyetherketoneketone and its compounds modified with different physical and chemical properties can not only maintain the elastic modulus similar to human bones, increase the hardness, but also improve its biocompatibility, increase its antibacterial properties, and promote osseointegration. In oral and maxillofacial surgery, it can be used as a dental implant matrix, frame, and snap ring for removable partial dentures. Polyetherketoneketone can not only maintain good aesthetic advantages, but also has good fatigue resistance and retention, which is comparable to the oral cavity. The bonding system can ensure sufficient bonding ability, so polyetherketoneketone has great potential as a dental restoration material. In-depth research on the modification of polyetherketoneketone and its compound is still a hot topic. Through continuous improvement of the performance of the material, more in vivo and in vitro experiments have been carried out to confirm the superiority of polyetherketoneketone as an implant material for orthopedics and oral and maxillofacial surgery to make clinical transformation and it will have very good application prospects.

Key words: bone, material, polyetherketoneketone, implant, scaffold material, biocompatibility, tissue engineering, research progress, review

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