中国组织工程研究

中国组织工程研究 ›› 2015, Vol. 19 ›› Issue (12): 1909-1913.doi: 10.3969/j.issn.2095-4344.2015.12.020

• 材料生物相容性 material biocompatibility • 上一篇    下一篇

碳纤维椎间融合器与钛网椎间融合器修复腰椎退行性变：生物相容性比较

宋成哲1，金红旭2   

  1. 1沈阳市苏家屯区中心医院骨科，辽宁省沈阳市  110101
    2解放军沈阳军区总医院急诊医学部，辽宁省沈阳市  110840
  • 修回日期:2015-02-18 出版日期:2015-03-19 发布日期:2015-03-19
  • 通讯作者: 金红旭，主任医师，解放军沈阳军区总医院急诊医学部，辽宁省沈阳市 110840
  • 作者简介:宋成哲，男，1968年生，辽宁省沈阳市人，汉族，主治医师，主要从事创伤骨科的研究。
  • 基金资助:

    辽宁省自然科学基金(201202243)

Biocompatibility of carbon fiber interbody fusion cage versus titanium mesh cage in treatment of lumbar disc degeneration

Song Cheng-zhe1, Jin Hong-xu2   

  1. 1Department of Orthopedics, Central Hospital of Sujiatun District, Shenyang 110101, Liaoning Province, China
    2Department of Emergency Medicine, General Hospital of Shenyang Military Region, Shenyang 110840, Liaoning Province, China
  • Revised:2015-02-18 Online:2015-03-19 Published:2015-03-19
  • Contact: Jin Hong-xu, Chief physician, Department of Emergency Medicine, General Hospital of Shenyang Military Region, Shenyang 110840, Liaoning Province, China
  • About author:Song Cheng-zhe, Attending physician, Department of Orthopedics, Central Hospital of Sujiatun District, Shenyang 110101, Liaoning Province, China
  • Supported by:

    the Natural Science Foundation of Liaoning Province, No. 201202243

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摘要：

背景：不同材料椎间融合器可通过椎弓根钉内固定系统辅助使终板与椎间融合器紧密结合，为脊柱提供更加可靠的稳定性，重建椎间高度、腰椎生理角度和生物力学功能。
目的：比较碳纤维椎间融合器与钛网椎间融合器治疗腰椎退行性变的效果。
方法：选择L3-S1腰椎退行性变行后路椎体间融合患者60例，其中男33例，女27例，随机均分为碳纤维组和钛网组，碳纤维组采用后路椎体间融合置入碳纤维椎间融合器与自体骨，同时辅以椎弓根钉内固定系统；钛网组采用后路椎体间融合置入钛网融合器与自体骨，同时辅以椎弓根钉内固定系统辅助。比较两组融合器置入前后JOA评分、椎间高度、椎间融合情况和并发症。
结果与结论：60例均完成3-27个月随访，获得良好的骨融合，治疗后3个月腰部活动基本恢复正常。两组置入后3个月的JOA评分、置入后1周的椎间高度均较置入前明显改善(P < 0.05)，两组间比较差异无显著性意义。两组材料均未发生排异反应，无感染发生，具有良好的生物相容性，其中钛网组出现融合器下沉2例。表明碳纤维椎间融合器和钛网椎间融合器置入治疗腰椎退行性变均具有良好的生物相容性，可提高椎体稳定性，恢复椎间高度，但碳纤维椎间融合器并发症的发生率更低。


中国组织工程研究杂志出版内容重点：生物材料；骨生物材料; 口腔生物材料; 纳米材料; 缓释材料; 材料相容性；组织工程


全文链接：

关键词: 生物材料, 骨生物材料, 碳纤维椎间融合器, 钛网融合器, 骨融合, 椎体稳定性, 辽宁省自然科学基金

Abstract:

BACKGROUND: The endplate can be combined closely with different intervertebral fusion cages through the pedicle screw internal fixation system, to provide a more reliable spine stability for reconstruction of intervertebral height, lumbar physiological curvature and biomechanical function.
OBJECTIVE: To compare the effectiveness of carbon fiber interbody fusion cage and titanium mesh cage in lumbar disc degeneration.
METHODS: Sixty patients with L3-S1 lumbar disc degeneration who underwent posterior lumbar interbody fusion, 33 males and 27 females, were randomized into carbon fiber interbody fusion cage group and titanium mesh cage group. Japanese Orthopaedic Association Scores were compared between the two groups before and after the implantation, as well as the intervertebral height, intervertebral fusion and complications.
RESULTS AND CONCLUSION: Sixty patients completed the 3-27 months follow-up, and had good bone fusion. Lumbar activity was normal in all the patients at 3 months after treatment. The Japanese Orthopaedic Association Scores at 3 months after implantation and the intervertebral height at 1 week after implantation were significantly improved in the two groups (P < 0.05), but there was no difference between the two groups. The materials in the two groups had good biocompatibility with no rejection and no infection. Fusion cage subsidence occurred in two cases from the titanium mesh cage group. These findings indicate that both of carbon fiber interbody fusion cage and titanium mesh cage have good biocompatibility, improve the stability of the vertebral body, and restore the intervertebral height. Moreover, the carbon fiber material performance is better than the metal titanium mesh because of lower complication rate.


中国组织工程研究杂志出版内容重点：生物材料；骨生物材料; 口腔生物材料; 纳米材料; 缓释材料; 材料相容性；组织工程


全文链接：

Key words: Spinal Fusion, Lumbar Vertebrae, Biocompatible Materials

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