中国组织工程研究 ›› 2019, Vol. 23 ›› Issue (25): 4068-4074.doi: 10.3969/j.issn.2095-4344.1790

• 干细胞综述 stem cell review • 上一篇    下一篇

不同来源干细胞在口腔骨再生中的应用

沈梦杰,杨  琨,刘  琪
  

  1. 遵义医学院附属口腔医院牙周科,贵州省遵义市  563003
  • 修回日期:2019-04-28 出版日期:2019-09-08 发布日期:2019-09-08
  • 通讯作者: 刘琪,博士,教授,遵义医学院附属口腔医院牙周科,贵州省遵义市 563003
  • 作者简介:沈梦杰,女,1990年生,安徽省阜阳市人,汉族,遵义医学院在读硕士,主要从事牙周组织再生方面的研究。
  • 基金资助:

    国家自然科学基金(81860196),项目负责人:刘琪;国家自然科学基金(81760199),项目负责人:杨琨

Application potential of different origin stem cells in oral bone regeneration

Shen Mengjie, Yang Kun, Liu Qi
  

  1. Department of Periodontology, Stomatological Hospital Affiliated to Zunyi Medical University, Zunyi 563003, Guizhou Province, China
  • Revised:2019-04-28 Online:2019-09-08 Published:2019-09-08
  • Contact: Liu Qi, MD, Professor, Department of Periodontology, Stomatological Hospital Affiliated to Zunyi Medical University, Zunyi 563003, Guizhou Province, China
  • About author:Shen Mengjie, Master candidate, Department of Periodontology, Stomatological Hospital Affiliated to Zunyi Medical University, Zunyi 563003, Guizhou Province, China
  • Supported by:

    the National Natural Science Foundation of China, No. 81860196 (to LQ) and 81760199 (to YK)

摘要:

文章快速阅读:

文题释义:
干细胞工程:
利用现代生物医学和组织工程技术,通过对间充质干细胞、胚胎干细胞、造血干细胞、神经干细胞等前体细胞,进行体外分离纯化、定向诱导分化等整合构建,重构骨、软骨、神经、血管等组织。
牙龈卟啉单胞菌:牙周病是一种慢性感染性疾病,由多种牙周可疑致病菌的感染引起。牙龈卟啉单胞菌是其中的主要致病菌,牙龈卟啉单胞菌脂多糖在牙周组织的破坏中发挥了重要作用。

 

摘要
背景:
近年来,随着干细胞与再生技术的不断进步,骨组织工程得到了迅速的发展。虽然应用于骨组织工程中的种子细胞已经有很多,但对于不同的疾病,研究人员和临床工作者仍然面临着最佳种子细胞选择的问题。口腔骨组织重建是近年来研究的一个热点,目前应用于口腔骨组织修复的方法很多,但还没有一种方法能够取得满意的临床效果。因此,充分利用干细胞在骨再生过程中的潜能将为口腔骨组织缺损修复提供一种新思路。
目的:对不同来源干细胞促进口腔骨组织再生的潜能进行综述,进而为组织工程选择种子细胞提供依据。
方法:以“干细胞,骨修复,牙槽骨再生,成骨,骨组织”“stem cell, bone repair, alveolar bone regenerate,osteogenesis,bone tissue”为关键词,检索中国生物医学文献数据库(CBM)、CNKI、PubMed、Elsevier以及Web of Science等数据库,通过阅读文题和摘要进行初步筛选,排除与文章主题不相关的文献,最终纳入81篇文献进行结果分析。
结果与结论:组织工程为口腔骨再生修复提供了新的方法,但是对于干细胞的选择还没有标准化。应用于骨组织再生的干细胞种类有很多,但因其来源不同在体内发挥的作用也不尽相同,对于特定组织损伤的修复,选择一种合适的干细胞就显得很重要。文章对胚胎干细胞、间充质干细胞以及诱导多能干细胞在口腔骨组织再生中的优缺点进行了比较,旨在为口腔骨组织再生修复种子细胞的选择提供一种参考。


中国组织工程研究杂志出版内容重点:干细胞;骨髓干细胞;造血干细胞;脂肪干细胞;肿瘤干细胞;胚胎干细胞;脐带脐血干细胞;干细胞诱导;干细胞分化;组织工程
ORCID: 0000-0002-1600-6357(沈梦杰);0000-0001-8041-6978(刘琪)

关键词: 干细胞, 胚胎干细胞, 间充质干细胞, 诱导多能干细胞, 牙槽骨修复, 骨再生, 成骨, 骨组织, 国家自然科学基金

Abstract:

BACKGROUND: In recent years, with the development of stem cell and regeneration technologies, bone tissue engineering has been rapidly developed. Despite there are a variety of seed cells for bone tissue engineering, researchers need to decide which types of stem cells are the best suitable for their specific purposes. To date, there is no ideal treatment for oral bone tissue repair, although a plenty of therapeutic methods have been proposed. Therefore, it will provide a new idea for repairing oral bone defects by fully utilizing the potential of stem cells during bone regeneration.
OBJECTIVE: To review the osteogenic potential of stem cells from different sources on oral bone regeneration, thereby providing a basis for selecting seed cells for tissue engineering.
METHODS: Databases of CBM, CNKI, PubMed, Elsevier, and Web of Science were retrieved with the keywords of “stem cell, bone repair, alveolar bone regenerate, osteogenesis, bone tissue” in English and Chinese, respectively. After initial screening of titles and abstracts, irrelevant articles were excluded and 81 eligible articles were included in final analysis.
RESULTS AND CONCLUSION: Tissue engineering technology provides a new approach to oral bone regeneration, but the choice of stem cells has not been standardized. Many types of stem cells have been used for bone tissue regeneration, but their roles in the body vary due to different origins of stem cells. Therefore, choosing a suitable type of stem cells is important for the repair of specific tissue damage. In this review, we compared the advantages and disadvantages of embryonic stem cells, mesenchymal stem cells and induced pluripotent stem cells in the oral bone regeneration, and attempted to provide a reference for the selection of seed cells for the regeneration and repair of oral bone tissue.

Key words: stem cells, embryonic stem cells, mesenchymal stem cells, induced pluripotent stem cells, alveolar bone repair, bone regeneration, osteogenesis, bone tissue, National Natural Science Foundation of China

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