中国组织工程研究 ›› 2019, Vol. 23 ›› Issue (25): 4082-4088.doi: 10.3969/j.issn.2095-4344.1775

• 干细胞综述 stem cell review • 上一篇    下一篇

干细胞治疗皮肤缺损:是未来研究的重点

刘博宇,蒲  磊,张应杰,杨应南,李亚雄
  

  1. 昆明医科大学附属延安医院心脏大血管外科,云南省昆明市  650051
  • 修回日期:2019-03-11 出版日期:2019-09-08 发布日期:2019-09-08
  • 通讯作者: 李亚雄,教授,昆明医科大学附属延安医院心脏大血管外科,云南省昆明市 650051
  • 作者简介:刘博宇,男,1993年生,云南省昆明市人,汉族,2019年昆明医科大学毕业,硕士,主要从事间充质干细胞研究。
  • 基金资助:

    云南省科技人才和平台计划(2018DG008),项目负责人:李亚雄

Stem cells in the treatment of skin defects: a focus of future research

Liu Boyu, Pu Lei, Zhang Yingjie, Yang Yingnan, Li Yaxiong
  

  1. Department of Cardiovascular Surgery, Affiliated Yan’an Hospital of Kunming Medical University, Kunming 650051, Yunnan Province, China
  • Revised:2019-03-11 Online:2019-09-08 Published:2019-09-08
  • Contact: Li Yaxiong, Professor, Department of Cardiovascular Surgery, Affiliated Yan’an Hospital of Kunming Medical University, Kunming 650051, Yunnan Province, China
  • About author:Liu Boyu, Master, Department of Cardiovascular Surgery, Affiliated Yan’an Hospital of Kunming Medical University, Kunming 650051, Yunnan Province, China
  • Supported by:

    the Science and Technology Talents and Platform Program of Yunnan Province, No. 2018DG008 (to LYX)

摘要:

文章快速阅读:

文题释义:
干细胞促进伤口愈合的机制:
干细胞可以通过免疫调节、分化、促血管生成等多方面促进伤口愈合,因此在皮肤缺损治疗上具有巨大潜力。许多干细胞,诸如皮肤来源干细胞、胚胎干细胞、诱导多能干细胞、间充质干细胞目前正在广泛的研究。自体间充质干细胞应用于皮肤缺损修复的研究取得了令人满意的结果,使其有很大的前景应用于临床治疗。
皮肤缺损:由烧伤、创伤、外科手术和糖尿病溃疡等多种损伤因素导致的皮肤及其附属器的缺失。皮肤缺损患者更容易发生感染并且难愈合,慢性皮肤缺损也严重影响患者的生活质量。

 

摘要
背景:
干细胞作为一种具备自我更新和多向分化能力的特殊细胞,有潜力应用于治疗皮肤缺损,并因其来源丰富、低免疫原性、能够分化为多个谱系细胞等特性,有望克服现有治疗手段的局限性并发展为新的治疗手段。
目的:阐明不同干细胞治疗皮肤缺损的机制及研究热点,寻求一种能够符合临床需求的细胞来源。?
方法:由第一作者检索1998至2018年PubMed数据库收录的与干细胞治疗皮肤缺损相关的文献。检索词为“stem cell,skin defect,wound healing”,按纳入、排除标准最后共纳入文献63篇进行综述。
结果与结论:干细胞在皮肤缺损治疗上具有巨大潜力,其不仅可以重建损伤的组织,而且可以通过免疫调节及血管新生促进伤口愈合。间充质干细胞与其他种类干细胞相比拥有更大优势,近年来间充质干细胞应用于皮肤缺损修复的研究取得了令人满意的结果,成为目前最理想的细胞来源,也是未来研究的重点。


中国组织工程研究杂志出版内容重点:干细胞;骨髓干细胞;造血干细胞;脂肪干细胞;肿瘤干细胞;胚胎干细胞;脐带脐血干细胞;干细胞诱导;干细胞分化;组织工程
ORCID: 0000-0001-5171-7069(刘博宇)

关键词: 干细胞, 间充质干细胞, 皮肤缺损, 伤口愈合, 免疫调节, 血管新生, 细胞分化

Abstract:

BACKGROUND: As a kind of special cells capable of self-renewal and multidirectional differentiation, stem cells have the potential in the treatment of skin defects. Owing to their rich sources, low immunogenicity, and multipotent differentiation ability, stem cells are expected to overcome the limitations of existing therapies and develop into new therapies.
OBJECTIVE: To overview the mechanisms and research focus of different stem cells in the treatment of skin defects, and to seek a kind of stem cells that meet clinical needs.
METHODS: The first author retrieved the databases of PubMed for relevant articles about stem cell-based therapies for skin defects published from 1998 to 2018. The key words were “stem cell, skin defect, wound healing” in English. In accordance with the inclusion and exclusion criteria, 63 articles were finally reviewed.?
RESULTS AND CONCLUSION: Stem cells have tremendous potential in the treatment of skin defects. These cells cannot only regenerate damaged tissue, but also promote the wound healing by immunomodulation and angiogenesis. Compared with other types of stem cells, mesenchymal stem cells have more advantages. Studies concerning mesenchymal stem cells have achieved satisfactory results in recent years. Mesenchymal stem cells have become the most ideal cells for the treatment of skin defects, and they are also the focus of future research.

Key words: stem cells, mesenchymal stem cells, skin defect, wound healing, immune regulation, angiogenesis, cell differentiation

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