中国组织工程研究 ›› 2019, Vol. 23 ›› Issue (17): 2782-2788.doi: 10.3969/j.issn.2095-4344.1730

• 干细胞综述 stem cell review • 上一篇    

牙源性间充质干细胞促进牙周组织再生的可能性与前景

都沙沙,蔡智国,杨 琨,刘 琪   

  1. 遵义医学院附属口腔医院牙周科,贵州省遵义市 563003
  • 修回日期:2019-02-12 出版日期:2019-06-18 发布日期:2019-06-18
  • 通讯作者: 刘琪,博士,教授,遵义医学院附属口腔医院牙周科,贵州省遵义市 563003
  • 作者简介:都沙沙,女,1991年生,贵州省遵义市人,汉族,在读硕士,医师,主要从事2型糖尿病伴牙周炎方面的研究。
  • 基金资助:

    国家自然科学基金项目(81860196),项目负责人:刘琪;国家自然科学基金项目(81760199),项目负责人:杨琨

Dental-derived mesenchymal stem cells promote periodontal tissue regeneration: possibility and prospects

Du Shasha, Cai Zhiguo, Yang Kun, Liu Qi   

  1. Department of Periodontology, Hospital of Stomatology, Zunyi Medical University, Zunyi 563003, Guizhou Province, China
  • Revised:2019-02-12 Online:2019-06-18 Published:2019-06-18
  • Contact: Liu Qi, MD, Professor, Department of Periodontology, Hospital of Stomatology, Zunyi Medical University, Zunyi 563003, Guizhou Province, China
  • About author:Du Shasha, Master candidate, Physician, Department of Periodontology, Hospital of Stomatology, Zunyi Medical University, Zunyi 563003, Guizhou Province, China
  • Supported by:

    the National Natural Science Foundation of China, No. 81860196 (to LQ) and 81760199 (to YK)

摘要:

文章快速阅读:

文题释义:
牙周炎:
是由菌斑微生物引起的牙周组织炎症破坏性疾病,主要表现为结合上皮破坏致使牙周袋形成,牙槽骨吸收;牙周炎的发展过程为活动期与静止期交替出现,晚期出现牙齿松动、脱落。
牙源性间充质干细胞:间充质干细胞是一种源自中胚层未分化的多功能干细胞,可以从胚胎早期阶段或出生后组织(成体干细胞)中分离,牙源性间充质干细胞主要源于乳牙和恒牙的牙周膜干细胞、根尖乳头衍生干细胞、脱落乳牙干细胞、牙囊干细胞、牙髓干细胞,能在病理条件下增殖和分化,具有良好的免疫耐受性,无异位组织形成,可作为组织工程和组织修复的理想种子细胞。

 

摘要
背景:
近年来,牙源性间充质干细胞在牙周炎模型牙周组织再生中取得了突破性进展,被认为是牙周组织再生的种子细胞,也是目前牙周组织重建的研究热点。
目的:综述牙源性间充质干细胞在牙周组织再生中的研究进展,并提出牙源性间充质干细胞促进牙周组织再生的潜在机制。
方法:以“牙周炎、牙源性间充质干细胞、牙周组织再生、多向分化能力、增殖、自我更新、迁移、归巢、免疫调节、衰老、牙周组织修复”为中文检索词;以“periodontitis,odontogenic mesenchymal stem cells/ dental-derived mesenchymal stem cells,periodontal tissue regeneration,multidirectional differentiation,proliferation and self-renewal,migration and homing,immune regulation,aging,repair of periodontal tissue”为英文检索词,检索CNKI与PubMed数据库1995至2018年间相关文献,纳入61篇文献进行综述,分析牙源性间充质干细胞的相关特性、修复牙周组织的潜在机制及研究进展。
结果与结论:在牙周炎动物模型及细胞模型中植入牙源性间充质干细胞,可形成牙周组织。牙源性间充质干细胞是重建牙周组织的一种新型治疗方法,但目前在牙周组织再生中的应用仍处于初期阶段,还面临干细胞增殖、分化、迁移和归巢、衰老以及新生物与体内功能相适应等挑战。


中国组织工程研究杂志出版内容重点:干细胞;骨髓干细胞;造血干细胞;脂肪干细胞;肿瘤干细胞;胚胎干细胞;脐带脐血干细胞;干细胞诱导;干细胞分化;组织工程
ORCID:
0000-0002-1313-2374(都沙沙)

关键词: 牙周炎, 牙源性间充质干细胞, 多能分化能力, 细胞迁移, 细胞归巢, 牙周组织再生, 牙周组织修复, 国家自然科学基金

Abstract:

BACKGROUND: In recent years, dental-derived mesenchymal stem cells have made breakthroughs in the periodontal tissue regeneration of a periodontitis model, and they are the seed cells of periodontal tissue regeneration, which is also the hotspot study of periodontal tissue reconstruction 
OBJECTIVE: To review the research progress in the use of dental-derived mesenchymal stem cells in periodontal tissue regeneration, and to propose the potential mechanism by which dental-derived mesenchymal stem cells promote periodontal tissue regeneration.
METHODS: The related literatures addressing dental-derived mesenchymal stem cells and periodontal tissue regeneration published from 1995 to 2018 were retrieved in the databases of CNKI and PubMed. The keywords were “periodontitis, odontogenic mesenchymal stem cells/dental-derived mesenchymal stem cells, periodontal tissue regeneration, multidirectional differentiation, proliferation, self-renewal, migration, homing, immune regulation, aging, repair of periodontal tissue” in Chinese and English, respectively. Sixty-one articles were finally reviewed to analyze the characteristics and potential mechanisms of dental-derived mesenchymal stem cells for periodontal repair.
RESULTS AND CONCLUSION: Dental-derived mesenchymal stem cells that are implanted into an animal model of periodontitis or a cell model can differentiate into periodontal tissue. Dental-derived mesenchymal stem cells are a new treatment method for the reconstruction of periodontal tissue. However, its application in periodontal tissue regeneration is still in its infancy, and several challenges, such as stem cell proliferation, differentiation, migration and homing, aging and adaptation of new organisms to the function of the body, need to be overcome.

Key words: periodontitis, dental-derived mesenchymal stem cells, pluripotent differentiation, cell migration, cell homing, periodontal tissue regeneration, periodontal repair, National Natural Science Foundation of China

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