中国组织工程研究 ›› 2018, Vol. 22 ›› Issue (34): 5565-5570.doi: 10.3969/j.issn.2095-4344.0687

• 生物材料综述 biomaterial review • 上一篇    下一篇

细菌纤维素在创面修复中的研究与应用特性

张卫佳,刘 盈   

  1. 中山大学新华学院药学院,广东省广州市 510000
  • 收稿日期:2018-09-01 出版日期:2018-12-08 发布日期:2018-12-08
  • 通讯作者: 刘盈,助教,中山大学新华学院药学院,广东省广州市 510000
  • 作者简介:张卫佳,男,1980年生,安徽省池州市人,汉族,2008年西华大学毕业,硕士,讲师,主要从事生物制药研究。
  • 基金资助:

    广东普通高校教育科学“十二五”规划2014年项目(2014GXJK208):微课在高校《生物化学》教学中的应用研究

Properties of bacterial cellulose in wound repair

Zhang Weijia, Liu Ying   

  1. School of Pharmacy, Xinhua College of Sun Yat-Sen University, Guangzhou 510000, Guangdong Province, China
  • Received:2018-09-01 Online:2018-12-08 Published:2018-12-08
  • Contact: Liu Ying, Assistant teacher, School of Pharmacy, Xinhua College of Sun Yat-Sen University, Guangzhou 510000, Guangdong Province, China
  • About author:Zhang Weijia, Master, Lecturer, School of Pharmacy, Xinhua College of Sun Yat-Sen University, Guangzhou 510000, Guangdong Province, China
  • Supported by:

    The 2014 High Education Science Project in Guangdong Province during the Twelfth Five-Year Period, No. 2014GXJK208

摘要:

文章快速阅读:

 

文题释义:
细菌纤维素:
又称微生物纤维素,是由细菌在一定生长条件下分泌产生的纳米级纤维素,直径介于1-100 nm之间。有别于植物纤维素与木质素、半纤维素等相伴相生,细菌纤维素以纯纤维素的形式分泌,因此也被认为是最纯的天然纤维素。细菌纤维素形成独特的织态结构,并因“纳米效应”而具有高吸水性和高保水性、对液体和气体的高透过率、高湿态强度,尤其在湿态下可原位加工成型等特性。高纯度和优异的性能使细菌纤维素纤维可在医疗领域广泛应用。
天然生物聚合物:一直是医学领域和相关领域的研究重点。因此,许多科学家致力于研究这些材料,它们与原生组织固有的复杂、多级结构非常相似。这些材料的医疗用途包括伤口敷料、医用植入物、药物输送体、人造血管和组织工程支架。天然生成的生物聚合物如胶原蛋白、透明质酸、明胶、壳聚糖和纤维素,由于自身的性质与原生组织相似,已被应用于生物医学领域。其中纤维素是地球上最丰富的天然生物聚合物,具有独特的特性,已成为有用材料转化的理想起点。


背景:细菌纤维素天然交织形成的超精细纳米级三维网络结构,已成为国内外新型生物医用材料的新方向。
目的:通过总结细菌纤维素的原始组成和作为纳米材料等多种形式的应用,探讨其在生物医学领域的应用。
方法:以“细菌纤维素,组织工程,医用材料,抗张强度”为中文关键词,以“Bacterial cellulose,tissue engineering,medical material,tensile strength”为英文关键词,检索CNKI、万方及PubMed、Medline数据库中有关细菌纤维素在创面修复中的应用研究的相关文献,总结细菌纤维素在创面修复中的应用现状,分析存在的问题及前景。
结果与结论:细菌纤维素是由微生物分泌的一种高纯度、高结晶度的超细纳米纤维素,静置培养条件下可交织成多孔网络结构,其化学结构稳定、吸水性佳、透气性好、机械强度高、生物相容性良好,是理想的生物医用材料,特别在创面修复领域具有广泛的应用前景。目前已开发出细菌纤维素创面敷料产品,被证实能够促进组织再生和加速创面愈合。

ORCID: 0000-0002-7777-7091(刘盈)

中国组织工程研究杂志出版内容重点:生物材料;骨生物材料; 口腔生物材料; 纳米材料; 缓释材料; 材料相容性;组织工程

关键词: 细菌纤维素, 创面修复, 医用材料, 抗张强度, 杨氏模量, 生物材料

Abstract:

BACKGROUND: The ultra-fine nano-scale three-dimensional network structure formed by the natural interweaving of bacterial cellulose has become a new research direction of new biomedical materials.

OBJECTIVE: To explore the application of bacterial cellulose in the biomedicine by summarizing the original composition and multiform of bacterial cellulose as a nanomaterial.
METHODS: The keywords of “bacterial cellulose, tissue engineering, medical material, tensile strength” in Chinese and English were used to search CNKI, WanFang, PubMed and Medline databases for articles addressing the pro-vascularization of bacterial cellulose in wound repair. Then, the application of bacterial cellulose in wound repair was summarized, and the existing problems and prospects were also analyzed.

RESULTS AND CONCLUSION: Bacterial cellulose secreted by the microorganism is of high purity and crystallinity. The nanofibers of bacterial cellulose form the porous network structure during static culture. It is considered as one of the ideal biomedical materials owing to its stable chemical structure, high water absorbency, good air permeability, great mechanical strength and biocompatibility. Especially in the field of wound repair, bacterial cellulose has been deeply studied and developed as the promising wound dressing, which is proven to promote tissue regeneration and accelerate wound healing.

 

Key words: Cellulose, Biological Dressings, Tissue Engineering

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