中国组织工程研究 ›› 2018, Vol. 22 ›› Issue (5): 787-792.doi: 10.3969/j.issn.2095-4344.0452

• 干细胞综述 stem cell review • 上一篇    下一篇

干细胞修复宫腔粘连:初级阶段研究成果的转化意义

占欣璐,周梦妮,谭布珍   

  1. 南昌大学第二附属医院妇产科,江西省南昌市 330000
  • 修回日期:2017-09-24 出版日期:2018-02-18 发布日期:2018-02-18
  • 通讯作者: 谭布珍,硕士,教授,博士生导师,主任医师,南昌大学第二附属医院妇产科,江西省南昌市 330000
  • 作者简介:占欣璐,女,1993年生,江西省上饶市人,汉族,南昌大学医学院在读硕士,医师,主要从事卵巢癌方向研究。
  • 基金资助:

    江西省社发领域重点项目(2106BBG70218);南昌大学研究生创新专项资金(cx2016338)

Stem cell repair of intrauterine adhesions: preliminary achievements and clinical translation

Zhan Xin-lu, Zhou Meng-ni, Tan Bu-zhen   

  1. Department of Obstetrics and Gynecology, the Second Affiliated Hospital of Nanchang University, Nanchang 330000, Jiangxi Province, China
  • Revised:2017-09-24 Online:2018-02-18 Published:2018-02-18
  • Contact: Tan Bu-zhen, Master, Professor, Doctoral supervisor, Chief physician, Department of Obstetrics and Gynecology, the Second Affiliated Hospital of Nanchang University, Nanchang 330000, Jiangxi Province, China
  • About author:Zhan Xin-lu, Studying for master’s degree, Physician, Department of Obstetrics and Gynecology, the Second Affiliated Hospital of Nanchang University, Nanchang 330000, Jiangxi Province, China
  • Supported by:

    the Social Development Project of Jiangxi Province, No. 2106BBG70218; the Innovative Foundation for Postgraduates in Nanchang University, No. cx2016338

摘要:

文章快速阅读:

文题释义:
Asherman综合征:
即宫腔粘连,由 Joseph G. Asherman 于 1948 年首次详细报道而由此得名,定义为由于内膜损伤导致宫腔部分或全部闭塞的一组疾病,表现为月经异常、不孕、反复流产,是妇科的常见病、多发病,多数宫腔粘连患者都伴有继发性不孕。
子宫内膜干细胞:人子宫内膜干细胞可由刮宫术或从月经血组织中提取,相较于其他类型干细胞,具有来源广、取材方便、无伦理学争议等优势。重度宫腔粘连患者内膜功能受损,多数继发生育能力低下,子宫内膜干细胞再生疗法可从根本上解决内膜缺失的问题,给宫腔粘连的治疗提供了新的思路。但目前关于子宫内膜干细胞的分离、培养及鉴定都没有一个公认的流程和技术,为促进子宫内膜干细胞用于临床,制定一个规范的培养流程是未来研究的重点。

 

摘要
背景:
干细胞在组织、器官修复中表现出了巨大的应用潜能。但对于干细胞移植治疗宫腔粘连的研究还处于初级阶段。
目的:对干细胞修复治疗宫腔粘连的研究进展进行综述。
方法:应用计算机检索ISI Web of Science数据库、PubMed 数据库及中国知网数据库中有关干细胞治疗宫腔粘连的具有代表性的相关文献,在关键词中以“宫腔粘连、干细胞、子宫内膜干细胞、干细胞移植、 intrauterine adhesion、metrosynizesis、Asherman's syndrome、 stem cell、endometrial stem cell、stem cell transplantation”为检索词进行检索。文献包括临床研究、基础研究及综述类文章,排除重复性研究后,从中选择43篇文献进行综述。
结果与结论:宫腔镜下宫腔粘连分离术是目前治疗宫腔粘连的最理想方法,但术后宫腔粘连复发率仍较高。人类的子宫内膜有高度增殖活性,一个育龄期女性的子宫内膜要经过400多次的生长、分化和剥脱,提示了子宫内膜干细胞的存在。目前已从子宫内膜中分离出子宫内膜干细胞,并在体外成功培养并诱导其定向分化,但对于子宫内膜干细胞移植治疗宫腔粘连的研究还处于初级阶段。随着对干细胞基础研究的加深,其在临床治疗中应用也越来越广泛。

中国组织工程研究杂志出版内容重点:干细胞;骨髓干细胞;造血干细胞;脂肪干细胞;肿瘤干细胞;胚胎干细胞;脐带脐血干细胞;干细胞诱导;干细胞分化;组织工程
ORCID: 0000-0001-6093-2158(谭布珍)

关键词: 子宫内膜干细胞, 宫腔粘连, 子宫内膜再生, 胚胎干细胞, 骨髓干细胞, 干细胞, 细胞培养

Abstract:

BACKGROUND: Stem cells exhibit immeasurable application potentials in tissue and organ repair, but stem cell transplantation for the treatment of intrauterine adhesions is still in the initial stage.
OBJECTIVE: To review the research progress in the stem cell repair of intrauterine adhesions.
METHODS: We retrieved ISI Web of Science database, PubMed database and CNKI database for representative clinical research, basic research and reviews concerning stem cell therapy for intrauterine adhesions. The keywords were "intrauterine adhesion, metrosynizesis, Asherman's syndrome, stem cell, endometrial stem cell, stem cell transplantation” in English and Chinese, respectively. After repetitive studies were excluded, 43 articles were reviewed in the result analysis.
RESULTS AND CONCLUSION: Hysteroscopic transcervical resection of adhesions is an ideal treatment for intrauterine adhesions, but the postoperative recurrence rate of intrauterine adhesions is still high. The human endometrium has high proliferative activity, and the endometrium of a woman of childbearing age may experience growth, differentiation and exfoliation for over 400 times, indicating the existence of endometrial stem cells. Endometrial stem cells have been isolated from the endometrium, successfully cultured in vitro and induced for directional differentiation. However, studies on endometrial stem cell transplantation for intrauterine adhesions are still in its infancy. Basic research on stem cells will facilitate its application to clinical practice. 

中国组织工程研究杂志出版内容重点:干细胞;骨髓干细胞;造血干细胞;脂肪干细胞;肿瘤干细胞;胚胎干细胞;脐带脐血干细胞;干细胞诱导;干细胞分化;组织工程

Key words: Hysteroscopy, Tissue Adhesions, Endometrium, Mesenchymal Stem Cells, Tissue Engineering

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