中国组织工程研究

中国组织工程研究 ›› 2012, Vol. 16 ›› Issue (21): 3869-3872.doi: 10.3969/j.issn.1673-8225.2012.21.016

• 材料生物相容性 material biocompatibility • 上一篇    下一篇

生物人工硬脑膜在颅脑损伤患者硬脑膜缺损中的应用

罗武锋，李汉城，陈曼华，刘俊波，洪映标   

  1. 揭阳市人民医院神经外二科，广东省揭阳市   522000
  • 收稿日期:2011-10-15 修回日期:2012-01-26 出版日期:2012-05-20 发布日期:2012-05-20
  • 作者简介:罗武锋，男，1975年生，汉族，广东省揭阳市人，1999年中山医科大学毕业，主治医师，主要从事神经外科方面的研究。 luowufeng@ 126.com

Clinical application of bio-artificial duramater in repair of dural defects in traumatic brain injury patients 

Luo Wu-feng, Li Han-cheng, Chen Man-hua, Liu Jun-bo, Hong Ying-biao   

  1. Department of Neurosurgery, Jieyang People’s Hospital, Jieyang  522000, Guangdong Province, China
  • Received:2011-10-15 Revised:2012-01-26 Online:2012-05-20 Published:2012-05-20
  • About author:Luo Wu-feng, Attending physician, Department of Neurosurgery, Jieyang People’s Hospital, Jieyang 522000, Guangdong Province, China luowufeng@126.com

PDF

315

被引次数

14

摘要：

背景：硬膜的完整性对于颅脑损伤患者手术的预后十分重要。
目的：观察并分析生物人工硬脑膜在颅脑损伤手术松弛缝合中修补硬膜缺损的临床资料，并评价其使用价值。
方法：回顾性分析132例颅脑损伤中硬脑膜缺损者应用人工硬脑膜修补后的疗效及并发症随访结果。
结果与结论：患者随访1年，共64例患者进入结果分析。应用人工硬脑膜后脑积水22例，皮下积液8例，硬膜外血肿4例，脑脊液切口漏2例、鼻漏1例，修复后头颅CT检查未见与人工脑膜有关的异常反应和表现。42例患者3~6个月进行颅骨修补时发现人工硬脑膜与正常硬脑膜融合恢复较好，无粘连及炎症反应发生。说明实验所用生物型人工硬膜并发症少，相容性好，能够较好的与正常硬脑膜融合，保护脑皮质。
关键词：生物人工硬脑膜；颅脑损伤；硬薄膜缺损；并发症；松弛缝合
doi:
背景：硬膜的完整性对于颅脑损伤患者手术的预后十分重要。
目的：观察并分析生物人工硬脑膜在颅脑损伤手术松弛缝合中修补硬膜缺损的临床资料，并评价其使用价值。
方法：回顾性分析132例颅脑损伤中硬脑膜缺损者应用人工硬脑膜修补后的疗效及并发症随访结果。
结果与结论：患者随访1年，共64例患者进入结果分析。应用人工硬脑膜后脑积水22例，皮下积液8例，硬膜外血肿4例，脑脊液切口漏2例、鼻漏1例，修复后头颅CT检查未见与人工脑膜有关的异常反应和表现。42例患者3~6个月进行颅骨修补时发现人工硬脑膜与正常硬脑膜融合恢复较好，无粘连及炎症反应发生。说明实验所用生物型人工硬膜并发症少，相容性好，能够较好的与正常硬脑膜融合，保护脑皮质。
关键词：生物人工硬脑膜；颅脑损伤；硬薄膜缺损；并发症；松弛缝合
doi:10.3969/j.issn.1673-8225.2012.21.016

关键词: 生物人工硬脑膜, 颅脑损伤, 硬薄膜缺损, 并发症, 松弛缝合

Abstract:

BACKGROUND: The integrity of the dura mater is very important for the prognosis of patients with head injury.
OBJECTIVE: To observe and analyze the clinical data regarding the application of bio-artificial duramater in dural relaxing suture in patients with traumatic brain injury as well as to evaluate the use value.
METHODS: We retrospectively reviewed the curative effects of bio-artificial duramater in the repair of dural defects in 132 cases of traumatic brain injury as well as follow-up results.
RESULTS AND CONCLUSION: By the end of 1-year follow-up, 64 patients were included in result analysis. After operation, there were 22 cases of hydrocephalus, eight cases of subcutaneous effusion, four cases of extradural hematoma, two cases of cerebrospinal fluid incision leakage and one case of rhinorrhea. After repair, head CT revealed no abnormal reactions related to bio-artificial duramater. Forty-two patients had a good fusion of artificial duramater and normal dura mater, and no adhesion and inflammatory reactions after 3-6 months. These findings indicate that bio-artificial duramater can reduce complications, have a good fusion with the normal dura mater and protect the cerebral cortex.

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