中国组织工程研究

中国组织工程研究 ›› 2012, Vol. 16 ›› Issue (13): 2427-2430.doi: 10.3969/j.issn.1673-8225.2012.13.034

• 骨与关节学术探讨 academic discussion of the bone and joint • 上一篇    下一篇

股骨头坏死的组织工程修复

龙腾河，崔惠勤，李  涛   

  1. 广西医科大学附属第四医院放射科，广西壮族自治区柳州市 545005
  • 收稿日期:2012-01-22 修回日期:2012-02-22 出版日期:2012-03-25 发布日期:2012-03-25
  • 通讯作者: author: Cui Hui-qin, Master, Chief physician, Professor, Master’s supervisor, Department of Radiology, Fourth Affiliated Hospital, Guangxi Medical University, Liuzhou 545005, Guangxi Zhuang Autonomous Region, China cuihuiqin2009@hotmail.com
  • 作者简介:龙腾河，男，1965年生，广西壮族自治区融安县人，汉族，2004年广西医科大学毕业，副主任医师，主要从事医学影像放射方面的研究。longtenhe1965@yahoo.com.cn

Tissue engineering repair for femoral head necrosis

Long Teng-he, Cui Hui-qin, Li Tao   

  1. Department of Radiology, Fourth Affiliated Hospital, Guangxi Medical University, Liuzhou  545005, Guangxi Zhuang Autonomous Region, China
  • Received:2012-01-22 Revised:2012-02-22 Online:2012-03-25 Published:2012-03-25
  • Contact: 崔惠勤，女，硕士，主任医师，教授，硕士生导师，广西医科大学附属第四医院放射科，广西壮族自治区柳州市 545005 cuihuiqin2009@hotmail.com
  • About author:Long Teng-he, Associate chief physician, Department of Radiology, Fourth Affiliated Hospital, Guangxi Medical University, Liuzhou 545005, Guangxi Zhuang Autonomous Region, China longtenhe1965@yahoo.com.cn

PDF

349

被引次数

5

摘要：

背景：随着组织工程学技术的发展，改变了治疗骨缺损的传统治疗模式。由于骨组织是可再生组织，医学研究者们越来越重视组织工程在股骨头坏死治疗中的应用。
目的：总结股骨头坏死的组织工程修复手段，探索再生医学在骨组织工程领域的医用前景。
方法：从组织工程医学关注的几个前沿领域，包括 “干细胞、组织构建与生物力学、骨科生物材料、人工假体置换、植骨移植”等出发，检索与这些组织工程技术手段修复股骨头坏死相关研究的文献，时间限定为2000-01/2011-12，排除重复研究和Meta分析类文章，对30篇具有代表性的文献进行综合分析。
结果与结论：随着再生医学的进步，组织工程技术已经广泛应用于股骨头坏死的修复，包括：不同来源干细胞移植治疗股骨头坏死、炎症因子与股骨头坏死分析、股骨头坏死有限元模型的构建及生物力学分析、各种高分子生物骨支架材料修复股骨头坏死、人工骨植入及人工髋关节置换等。但目前组织工程在股骨头坏死治疗过程中仍处在动物实验和经验性治疗水平。                                                                        
关键词：股骨头坏死；干细胞；生物材料；髋关节置换；植骨；生物力学
doi:10.3969/j.issn.1673-8225.2012.13.034

关键词: 股骨头坏死, 干细胞, 生物材料, 髋关节置换, 植骨, 生物力学

Abstract:

BACKGROUND: The development of tissue engineering technique changed the manner for treating bone defect. Because bone tissues are reproducible, more and more medical investigators paid a great attention on application of tissue engineering in treatment of femoral head necrosis.
OBJECTIVE: To summarize the tissue engineering repair manner of femoral head necrosis, and to explore the perspective of regenerative medicine in bone tissue engineering.
METHODS: We retrieved articles regarding tissue engineering techniques in repair of femoral head necrosis from aspects of frontier fields of tissue engineering, including stem cells, tissue construction and biomechanics, orthopedics biomaterial, artificial prosthetic replacement, bone graft transplantation published from January 2000 to December 2011. Repetitive or Meta analysis articles were excluded. A total of 30 representative articles were analyzed.
RESULTS AND CONCLUSION: With the progression of regenerative medicine, tissue engineering technique had been widely used in repair of femoral head necrosis, containing stem cells from different sources transplantation for treating femoral head necrosis, inflammatory factor and femora head necrosis, construction and biomechanical analysis of finite element model of femoral head necrosis, varied giant molecular organism bone scaffold in repair of femoral head necrosis, artificial bone implantation and artificial hip joint replacement. However, present tissue engineering in treatment of femoral head necrosis is still in animal experiment and empirical treatment levels.

中图分类号: