中国组织工程研究

中国组织工程研究 ›› 2012, Vol. 16 ›› Issue (13): 2407-2410.doi: 10.3969/j.issn.1673-8225.2012.13.029

• 骨与关节综述 bone and joint review • 上一篇    下一篇

Wnt/β-连环蛋白信号通路在骨关节炎发生过程中的作用**★

李盛村，鲍  捷，王国祥   

  1. 苏州大学体育学院，江苏省苏州市  215000
  • 收稿日期:2011-08-13 修回日期:2011-09-17 出版日期:2012-03-25 发布日期:2012-03-25
  • 通讯作者: 王国祥，教授，博士生导师，苏州大学 体育学院，江苏 苏州 215000 kwang63@163.com
  • 作者简介:李盛村★，男，1985年生，浙江省温州市人，汉族，苏州大学体育学院在读硕士，主要从事运动医学研究。lccun8@126.com
  • 基金资助:

    江苏省2011年度普通高校研究生科研创新计划项目(CXZZ11_0069)；2011年江苏省高校自然科学研究面上自筹经费项目(11KJD320001)。

Role of Wnt/beta-catenin signal pathway in the occurrence of osteoarthritis 

Li Sheng-cun, Bao Jie, Wang Guo-xiang   

  1. Sport and Physical Education School of Soochow University, Suzhou  215000, Jiangsu Province, China
  • Received:2011-08-13 Revised:2011-09-17 Online:2012-03-25 Published:2012-03-25
  • Contact: author: Wang Guo-xiang, Professor, Doctoral supervisor, Sport and Physical Education School of Soochow University, Suzhou 215000, Jiangsu Province, China kwang63@163.com
  • About author:Li Sheng-cun★, Studying for master’s degree, Sport and Physical Education School of Soochow University, Suzhou 215000, Jiangsu Province, China lccun8@126.com
  • Supported by:

    Research and Innovation Project for College Graduate Students of Jiangsu in 2011, No. CXZZ11_0069*; General Self-financing Project of College Natural Science Research of Jiangsu in 2011, No. 11KJD320001*

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摘要：

背景：研究表明经典Wnt/β-连环蛋白信号通路与骨关节炎的发生发展有重要联系，Wnt蛋白家族、β-连环蛋白以及相关抑制因子可以调节软骨细胞功能和代谢。
目的：综述Wnt/β-连环蛋白信号通路与骨关节炎的关系。
方法：通过计算机检索 CNKI 和Elsevier数据库中2000/2011文献，关键词为“Wnt/β-catenin，OA，骨关节炎，软骨细胞”。选择与Wnt/β-连环蛋白信号通路对骨关节炎影响有关的文章内容。
结果与结论：目前研究表明经典Wnt/β-连环蛋白信号通路是维持关节完整性，调节关节软骨代谢的重要途径之一，对骨关节炎有重要影响。Wnt信号通路以及下游信号OPG/RANKL/RANK通过调节和控制关节软骨代谢，引发骨关节炎疾病，但具体机制有待进一步研究。研究Wnt通路的组分及其作用，不仅有助于骨关节炎的特定治疗，而且有利于预防骨质疏松及其他关节性疾病。
关键词：软骨代谢；Wnt/β-连环蛋白；信号通路；骨关节炎；软骨细胞
doi:10.3969/j.issn.1673-8225.2012.13.029

关键词: 软骨代谢, Wnt/&beta, -连环蛋白, 信号通路, 骨关节炎, 软骨细胞

Abstract:

BACKGROUND: Studies have shown that the classical Wnt/β-catenin signal pathway is closely related to the occurrence and development of osteoarthritis. Wnt protein family, β-catenin and related inhibitors can regulate the function and metabolism of chondrocytes.
OBJECTIVE: To summarize the relationship between Wnt/β- catenin signal pathway and osteoarthritis.
METHODS: A computer online search was performed to fine papers published between 2000 and 2011 in CNKI database and PubMed database. The key words of “Wnt/β-catenin, OA, osteoarthritis, cartilage cells” were used. Documents concerning the effects of Wnt/β- catenin signal pathway on osteoarthritis were included.
RESULTS AND CONCLUSION: Currently, studies show that the Wnt/β- catenin signal pathway is one of the important way to restrain the integrity of joint and regulate the metabolism of bone joint, can influence the osteoarthritis. Wnt signal pathway and its downstream signal osteoprotegerin/receptor activator of nuclear factor kappa B ligand/receptor activator of nuclear factor kappa B can regulate and control the articular cartilage metabolism result in osteoarthritis. However, the specific mechanism is still unclear. The research of components and effect of Wnt signal pathway are important for the special treatment of osteoarthritis and the prevention of osteoporosis or other diseases.

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