中国组织工程研究

中国组织工程研究 ›› 2012, Vol. 16 ›› Issue (8): 1505-1508.doi: 10.3969/j.issn.1673-8225.2012.08.039

• 生物材料临床实践 clinical practice of biomaterials • 上一篇    下一篇

基于生物材料创面敷料封闭负压引流在骨筋膜室综合征切开减压中的应用★

徐海栋，陈  勇，赏后来，卢俊浩，赵建宁   

  1. 解放军南京军区南京总医院骨科，江苏省南京市  210002
  • 收稿日期:2011-08-01 修回日期:2011-10-20 出版日期:2012-02-19 发布日期:2012-02-19
  • 通讯作者: 赵建宁，主任，教授，博士生导师，解放军南京军区南京总医院骨科，江苏省南京市 210002 zhaojlianning. 0207@163.com
  • 作者简介:徐海栋★，男，1980年生，安徽省安庆市人，2009年解放军第二军医大学毕业，硕士，主治医师，讲师，主要从事脊柱外科与生物材料研究。xuhaidong1980@163.com

Application of vacuum-sealing drainage based on biomaterial wound surface dressing in incision decompression of osteofascial compartment syndrome 

Xu Hai-dong, Chen Yong, Shang Hou-lai, Lu Jun-hao, Zhao Jian-ning   

  1. Department of Orthopaedics, Nanjing General Hospital of Nanjing Military Command of Chinese PLA, Nanjing  210002, Jiangsu Province, China
  • Received:2011-08-01 Revised:2011-10-20 Online:2012-02-19 Published:2012-02-19
  • Contact: Zhao Jian-ning, Professor, Doctoral supervisor, Department of Orthopaedics, Nanjing General Hospital of Nanjing Military Command of Chinese PLA, Nanjing 210002, Jiangsu Province, China 210002 zhaojlianning.0207@163.com
  • About author:Xu Hai-dong★, Master, Attending physician, Lecturer, Department of Orthopaedics, Nanjing General Hospital of Nanjing Military Command of Chinese PLA, Nanjing 210002, Jiangsu Province, China xuhaidong1980@ 163.com

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摘要：

背景：骨筋膜室综合征切开减压后往往出现肌肉膨出体外、大量组织液渗出导致肌肉创面不新鲜、易发生感染等不利于患者恢复，应用封闭负压引流可以保护创面，避免局部毒素入血。
目的：观察基于自主研发的生物材料创面敷料封闭负压引流在骨筋膜室综合征切开后的临床疗效。
方法：发生骨筋膜室综合征患者切开减压后采取自愿的原则，给予基于自主研发生物材料创面敷料封闭负压引流、合成材料创面敷料封闭负压引流和常规切开减压敷料包扎治疗。观察治疗后3 d患者肝肾功能指标及肉芽颗粒的新鲜度。
结果与结论：采用自主研发生物材料创面敷料、合成材料创面敷料封闭负压引流后均能明显保护患者的肝肾功能，肉芽组织颗粒的新鲜度为满意，优于常规切开减压敷料包扎组(P < 0.05)。采用合成材料创面敷料封闭负压引流组打开封闭负压时部分患者出现周围区域水泡。提示自主研发新型生物材料创面敷料能有效引流，避免患者毒素入血保护肝肾功能，同时肉芽组织颗粒的新鲜度满意，可为后期植皮提供良好的组织创面，并且具有良好的生物相容性。

关键词: 封闭负压引流, 生物材料, 创面敷料, 骨筋膜室综合征, 安全性

Abstract:

BACKGROUND: Muscle bulging in vitro, stale bone wounds caused by a large number of tissue fluid exudation and high incidence of infection often appear after incision decompression of osteofascial compartment syndrome, and these are not conducive to patient recovery. Vacuum-sealing drainage (VSD) can protect the wound and avoid local toxins to enter into the blood.
OBJECTIVE: To study the curative effect of VSD based on biomaterial wound surface dressing on incision decompression of osteofascial compartment syndrome.
METHODS: Osteofascial compartment syndrome patients received incision decompression were divided into three groups by their wishes: VSD based on biomaterial wound dressing group, VSD based on synthetic wound dressing group and routine pressure dressing group. Indexes of liver and kidney functions and freshness of granulation particles were observed in all patients after 3 days of treatment.
RESULTS AND CONCLUSION: The technique of VSD could significantly protect liver and kidney functions, and the freshness of granulation particles in the VSD groups were better compared with the routine pressure dressing group (P < 0.05). Blisters around the wound could be seen in partial patients of the VSD based on synthetic wound dressing group during drainage. It is indicated that VSD based on the new biomaterial wound dressing can effectively drainage, protect liver and kidney functions by avoid toxins entering into the blood, and have a satisfactory freshness of granulation particles. It can provide a good wound surface for later skin grafting and have a good biocompatibility.

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