中国组织工程研究

中国组织工程研究 ›› 2012, Vol. 16 ›› Issue (6): 1133-1136.doi: 10.3969/j.issn.1673-8225.2012.06.040

• 骨髓干细胞 bone marrow stem cells • 上一篇    下一篇

胎儿微嵌合体在经产妇疾病及组织损伤修复中的作用★

张国徽1，姬宏宇2   

  1. 1河北北方学院法医系，河北省张家口市  075000；2河北北方学院附属第一医院妇产科，河北省张家口市  075000
  • 收稿日期:2011-06-28 修回日期:2011-09-26 出版日期:2012-02-05 发布日期:2012-02-05
  • 作者简介:张国徽★，男，1966年生，河北省迁西县人，汉族，2003年河北医科大学毕业，硕士，教授，主要从事神经损伤修复的研究。

Function of fetal microchimerism during disease and tissue repair in parous women★

Zhang Guo-hui1, Ji Hong-yu2   

  1. 1Department of Forensic Medicine, Hebei North University, Zhangjiakou  075000, Hebei Province, China; 2Department of Gynecology and Obstetrics, the First Affiliated Hospital of Hebei North University, Zhangjiakou  075000, Hebei Province, China
  • Received:2011-06-28 Revised:2011-09-26 Online:2012-02-05 Published:2012-02-05
  • About author:Zhang Guo-hui★, Master, Professor, Department of Forensic Medicine, Hebei North University, Zhangjiakou 075000, Hebei Province, China yxyzgh@yahoo.com.cn

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摘要：

背景：胎儿微嵌合体是指存在于经产妇体内、来自胎儿的干细胞，其对母体健康的影响日益受到重视。
目的：介绍胎儿微嵌合体的检测手段、胎儿微嵌合体在母体疾病及组织损伤修复中的作用，引起临床对胎儿微嵌合体研究的重视。
方法：以“fetal microchimerism”为检索词，应用计算机检索Pubmed数据库2011-05-20之前的相关文章。纳入与胎儿微嵌合体研究相关的文献，排除重复性研究。
结果与结论：共检索到655篇文献，排除无关重复的文献，保留26篇文献进行综述。目前研究证实多种检测胎儿微嵌合体的手段可供研究者选择，胎儿微嵌合体在引起母体发生自身免疫性疾病、提高母体对于肿瘤等侵害因素的抵御能力、促进损伤修复等方面具有一定作用。

关键词: 胎儿微嵌合体, 组织修复, 自身免疫性疾病, 癌, 干细胞, 妊娠

Abstract:

BACKGROUND: Fetal microchimerism is a kind of stem cells which comes from fetus in pluripara. The research on fetal microchimerism is a hotspot because it may affect the health condition of pluripara.
OBJECTIVE: To introduce the methods of how to detect fetal microchimerism, and the function of fetal microchimerism during disease and tissue repair of the mother.
METHODS: “Fetal microchimerism” was used as a key word, and papers published before 2011-05-20 were retrieved in PubMed. Repetitive papers were eliminated.
RESULTS AND CONCLUSION: Totally 655 papers were retrieved, and finally 26 were reviewed. There are several methods used for fetal microchimerism detecting, and fetal microchimerism may pay an important role in the pathomechanism of pluripara autoimmune diseases, cancer and tissue repair.

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