中国组织工程研究

中国组织工程研究 ›› 2012, Vol. 16 ›› Issue (6): 1103-1106.doi: 10.3969/j.issn.1673-8225.2012.06.033

• 干细胞学术探讨 stem cell academic discussion • 上一篇    下一篇

基因和干细胞疗法修复慢性难愈创伤的研究与应用**★◆

夏章权1，2，张从纪1，王  涛3   

  1. 1解放军第三军医大学西南医院口腔科，重庆市 400038；2解放军291医院口腔科，内蒙古自治区包头市  014040；  3 解放军第三军医大学全军复合伤研究所，创伤、烧伤与复合伤国家重点实验室，重庆市  400038
  • 收稿日期:2011-07-13 修回日期:2011-09-01 出版日期:2012-02-05 发布日期:2012-02-05
  • 通讯作者: 张从纪，博士，副主任医师，副教授，硕士生导师。重庆第三军医大学西南医院口腔科，重庆市 400038 zhangcongji2@163.com
  • 作者简介:夏章权★，男，1982年生，湖北省随州市人，汉族，解放军第三军医大学毕业，硕士，主要从事创伤愈合方面的研究。 xiazq_0@yahoo.com.cn
  • 基金资助:

    国家自然科学基金项目(30670636)；重庆市自然科学基金项目(2006BB5095)。

Gene therapy and stem cell therapy in chronic wound healing 

Xia Zhang-quan1, 2, Zhang Cong-ji1, Wang Tao3   

  1. 1Department of Stomatology, Southwest Hospital of Third Military Medical University, Chongqing  400038, China; 2Department of Stomatology, the 291 Hospital of Chinese PLA, Baotou  014040, Inner Mongolia Autonomous Region, China; 3State Key Laboratory of Trauma, Burn and Combined Injury, Military Institute of Combined Injury, Third Military Medical University, Chongqing  400038, China
  • Received:2011-07-13 Revised:2011-09-01 Online:2012-02-05 Published:2012-02-05
  • Contact: author: Zhang Cong-ji, Doctor, Associate chief physician, Associate professor, Master’s supervisor, Department of Stomatology, Southwest Hospital of Third Military Medical University, Chongqing 400038, China zhangcongji2@163.com
  • About author:Xia Zhang-quan★, Master, Department of Stomatology, Southwest Hospital of Third Military Medical University, Chongqing 400038, China; Department of Stomatology, the 291 Hospital of Chinese PLA, Baotou 014040, Inner Mongolia Autonomous Region, China xiazq_0@yahoo.com.cn
  • Supported by:

    the National Natural Science Foundation of China, No. 30670636*; the Natural Science Foundation of Chongqing, No. 2006BB5095*

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摘要：

背景：许多疾病和因素都会使伤口久治不愈或延迟愈合，基因疗法和干细胞疗法为慢性难愈创伤的治疗提供了新的技术途径。
目的：针对基因疗法和干细胞疗法用于治疗慢性难愈创伤的研究作一综述。
方法：以“gene therapy，stem cell therapy和chronic wound”为检索词，检索Medline数据库(1980/2010-12)，文献检索语种限制为英语。将近年发表的针对性强的文章纳入研究范围，同一领域的文献则选择近期发表或权威杂志的文章。排除与基因疗法和干细胞疗法相关性不强、陈旧的文献。结合自身的研究经验和纳入排除标准，对查阅到的最新研究成果详细分析并加以总结概括。
结果与结论：初次检索到267篇文献，严格按照纳入标准，最终将33篇文献纳入研究。基因疗法和干细胞疗法都是新的治疗方法，其相关理论和技术已经成熟，为慢性难愈创伤的治疗提供了新的技术途径，它们的有效运用有望给慢性难愈创伤带来突破性的治疗效果。

关键词: 基因疗法, 干细胞疗法, 慢性难愈创伤, 愈合, 转染

Abstract:

BACKGROUND: A lot of diseases and factors can cause chronic wound or delayed wound healing. Cene theropy and stem cell therapy provide a new way for the treatment of chronic refractory wounds.
OBJECTIVE: To make a review of gene therapy and stem cell therapy in chronic wound healing
METHODS: A search across the databases of Medline (1980 to 2010-12) was performed, with key words of “gene therapy, stem cell therapy, chronic wound”. The literatures published in recent years with strong directions were included, and studies unrelated to the objective were excluded. Combined with our research experience, latest abroad researches were accessed and summed up.
RESULTS AND CONCLUSION: 267 articles were obtained from the preliminary search across the databases, and 33 documents were eventually included in the study. Gene therapy and stem cell therapy, of which theory and technology grow increasingly mature, have supplied two novel techniques to chronic wound healing and may take breakthrough to the treatment of chronic wound healing.

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