中国组织工程研究

中国组织工程研究 ›› 2012, Vol. 16 ›› Issue (3): 535-538.doi: 10.3969/j.issn.1673-8225.2012.03.035

• 生物材料学术探讨 biomaterial academic discussion • 上一篇    下一篇

不同心血管支架材料对老年冠心病患者内皮素和血管再狭窄的影响★

刘艳明1，王雪芳2   

  1. 1解放军第251医院心内二科，河北省张家口市  075000；2河北北方学院基础医学院，河北省张家口市  075000
  • 收稿日期:2011-07-13 修回日期:2011-08-09 出版日期:2012-01-15 发布日期:2012-01-15
  • 作者简介:刘艳明★，男，1973年生，河北省承德市人，满族，2008年河北医科大学毕业，硕士，副主任医师，主要从事心血管介入治疗研究。wxfang_2003@ yahoo.com.cn

Different cardiovascular stent materials effects on endothelin and vascular restenosis in elderly patients with coronary artery disease

Liu Yan-ming1, Wang Xue-fang2   

  1. 1Department of Cardiology Ⅱ, the 251 Hospital of Chinese PLA, Zhangjiakou  075000, Hebei Province, China; 2School of Basic Medicine, Hebei North University, Zhangjiakou  075000, Hebei Province, China
  • Received:2011-07-13 Revised:2011-08-09 Online:2012-01-15 Published:2012-01-15
  • About author:Liu Yan-ming★, Master, Associate chief physician, Department of Cardiology Ⅱ, the 251 Hospital of Chinese PLA, Zhangjiakou 075000, Hebei Province, China wxfang_2003@ yahoo.com.cn

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摘要：

背景：支架置入是治疗冠心病的有效方法。
目的：探讨不同心血管支架材料对老年冠状动脉粥样硬化性心脏病患者血管狭窄及血管内皮素含量的影响。
方法：由第一作者应用计算机检索维普数据网1995-01/2011-06文章。检索关键词为“心血管支架，老年冠心病，内皮素，血管再狭窄”。
结果与结论：单纯球囊扩张治疗老年冠心病患者漫性血管病变、血管壁损伤、血栓形成、炎性刺激的各种生长因子和细胞因子的产生较中青年明显增多，术后中远期靶血管再狭窄率比中青年高；金属裸支架置入降低了单纯球囊扩张靶血管再狭窄的发生率及血栓形成、各种生长因子和细胞因子的产生，改善了中远期靶血管再狭窄率；药物支架有效制止了血管弹性回缩和负性重塑，使老年冠心病支架置入中远期靶血管再狭窄率显著下降，减少了并发症的发生，改善了老年冠心病患者的生活质量。

关键词: 内皮素, 老年人, 冠心病, 支架置入, 生物材料

Abstract:

ACKGROUND: Stent implantation is an effective way to treat coronary heart disease.
OBJECTIVE: To study the effects of different cardiovascular stent materials on vascular restenosis and endothelin content in elderly patients with coronary heart disease.
METHODS: The first author searched VIP databases for articles published 1995-01/2011-06 using the keywords of cardiovascular stents, elderly coronary heart disease, endothelin, vascular restenosis”.
RESULTS AND CONCLUSION: Diffuse coronary vascular disease, vascular wall damage, thrombosis, inflammatory factors and cytokines are more seen in elderly patients than young and middle-aged patients receiving simple balloon angioplasty. Postoperative long- and middle-term vascular restenosis rate is also higher in young and middle-aged patients. Bare-metal stents can reduce the incidence of vascular restenosis and thrombosis and the production of various growth factors and cytokines as compared with simple balloon angioplasty. Drug stents are effective to inhibit vascular recoil and negative remodeling, reduce the incidence of long- and middle-term restenosis, decrease the occurrence of complications and improve the quality of life of elderly patients with coronary heart disease.

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