中国组织工程研究

中国组织工程研究 ›› 2011, Vol. 15 ›› Issue (25): 4695-4698.doi: 10.3969/j.issn.1673-8225.2011.25.033

• 生物材料学术探讨 biomaterial academic discussion • 上一篇    下一篇

不同生物材料修复跟腱损伤的应用

李  敏1，李广杰2   

  1. 1石家庄学院体育系，河北省石家庄市  050035
    2河北科技大学体育部，河北省石家庄市  050080
  • 收稿日期:2011-02-18 修回日期:2011-03-22 出版日期:2011-06-18 发布日期:2014-01-10
  • 作者简介:李敏★，女，1970年生，河北省无极县人，汉族，2004年河北师范大学体育学院毕业，硕士，副教授，主要从事运动康复、社会体育学研究。 Limin70@163.com

Application of different biomaterials in Achilles tendon repair

Li Min1, Li Guang-jie2   

  1. 1Department of Physical Education, Shijiazhuang University, Shijiazhuang  050035, Hebei Province, China
    2Department of Physical Education, Hebei University of Science and Technology, Shijiazhuang  050080, Hebei Province, China
  • Received:2011-02-18 Revised:2011-03-22 Online:2011-06-18 Published:2014-01-10
  • About author:Li Min★, Master, Associate professor, Department of Physical Education, Shijiazhuang University, Shijiazhuang 050035, Hebei Province, China Limin70@163.com

PDF

288

被引次数

8

摘要：

背景：构建组织工程化肌腱的关键是寻找适于肌腱细胞黏附、生长及功能分化的支架材料。
目的：评价不同生物材料在跟腱损伤修复中的效果。
方法：以“生物材料，跟腱，修复” 为关键词在万方数据库中检索1985-01/2011-01关于生物材料治疗跟腱缺损的文章。
结果与结论：陈旧性跟腱断裂难以自行愈合及修复，易遗留疼痛及功能障碍。长期以来，不少学者对跟腱缺损的治疗进行了较多的研究，从自体肌腱移植、同种异体肌腱移植到人工肌腱移植、组织工程肌腱移植等，实践证明这些方法手段都存在一定的优点和缺点。虽然肌腱组织工程中支架材料的研究与应用已经取得了一些成功，但是目前应用的材料或存在生物相容性问题、降解性问题或存在力学性能差、难加工成型等缺陷，与理想的支架材料还存在很大差距。

关键词: 聚乙烯纤维, 聚乳酸, 人发角蛋白, 跟腱损伤, 修复, 生物材料

Abstract:

BACKGROUND: The key to construct tissue engineered tendon is to look for appropriate scaffold materials for tendon cell adhesion, growth and functional differentiation.
OBJECTIVE: To assess the effects of different biomaterials on Achilles tendon injury.
METHODS: “Biomaterial, Achilles tendon, repair” were used as keywords to retrieve articles about biomaterials for treatment of Achilles tendon injuries published 1985-01/2011-01 in Wanfang database.
RESULTS AND CONCLUSION: Self-healing and repair of old Achilles tendon rupture is difficult, and pain and dysfunction easily occur. Over the years, there are many studies about treatment of Achilles tendon injuries from autologous tendon graft and tendon allograft to artificial tendon and tissue-engineered tendon. The above-mentioned methods have their own advantages and disadvantages. Although studies on scaffold materials for tissue-engineered tendon have achieved some results, the poor biocompatibility, degradation or mechanical properties as well as difficulty to molding lead to a great difference from ideal scaffold materials.

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