中国组织工程研究

中国组织工程研究 ›› 2011, Vol. 15 ›› Issue (12): 2213-2216.doi: 10.3969/j.issn.1673-8225.2011.12.030

• 生物材料学术探讨 biomaterial academic discussion • 上一篇    下一篇

壳聚糖及衍生物在药物制剂中的应用

张  晶1，宋力伟2   

  1. 1沈阳市妇女儿童保健中心，辽宁省沈阳市  110014
    2辽宁省职业病防治院，辽宁省沈阳市  110005
  • 收稿日期:2010-12-11 修回日期:2011-02-23 出版日期:2011-03-19 发布日期:2011-03-19
  • 作者简介:张晶，女，1964年生，山东省章丘市人，汉族，1996年沈阳药科大学毕业，副主任药师，主要从事药物制剂方面的研究。 cloud324@163.com

Application of chitosan and its derivant in pharmaceutical preparation

Zhang Jing1, Song Li-wei2   

  1. 1Shenyang Women and Children Health Center, Shenyang  110014, Liaoning Province, China
    2Occupational Disease Prevention Hospital of Liaoning Province, Shenyang  110005, Liaoning Province, China
  • Received:2010-12-11 Revised:2011-02-23 Online:2011-03-19 Published:2011-03-19
  • About author:Zhang Jing, Associate chief pharmacist, Shenyang Women and Children Health Center, Shenyang 110014, Liaoning Province, China cloud324@163.com

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774

被引次数

13

摘要：

目的：总结近年壳聚糖及衍生物在药物制剂中的应用现状。
方法：由作者应用计算机检索维普数据库，检索时限1999-01/2010-10。检索关键词：壳聚糖，缓释，药物，应用。纳入有关壳聚糖的制备方法及其在药物制剂中应用的文章，排除较陈旧文献。共保留相关文献20篇进入结果分析。
结果：壳聚糖具有良好的生物相容性、可生物降解性、无毒性和易成膜性，在国内外药学领域，壳聚糖应用于缓释、控释制剂的研究颇受人们关注。利用壳聚糖特有的物理化学性质，如遇酸膨胀形成凝胶、有良好成膜性及促进多肽类、蛋白质药物的透黏膜吸收等特点，人们一般将壳聚糖以片剂、成膜材料及微球、微囊等形式，作为缓释、控释制剂的骨架材料。
结论：用壳聚糖所开发的缓控释制剂，均衡了释药速率，减少了药物对正常组织细胞的毒副作用。

关键词: 壳聚糖, 药物制剂, 衍生物, 应用, 生物材料

Abstract:

OBJECTIVE: To summarize the application status of chitosan and derivant in pharmaceutical preparation.
METHODS: VIP database was retrieved by computer, the time was limited to 1999-01/2010-10. The index words were “chitosan, release, drug, application” in Chinese. Articles about the application status of chitosan and derivant in pharmaceutical preparation were included, outdated literatures were excluded. Totally 20 documents were involved for analysis.
RESULTS: Chitosan has a good biocompatibility, biodegradation, avirulent, and easily film-forming. In the field of pharmacy at home and abroad, chitosan was used to the research of release and controlled release preparation attracted people’s attention. The unique physical and chemical properties of chitosan, such as chitosan encounter acid expansion form a gel, have good film-forming and promote the polypeptide, transdermal absorption of protein drugs. Chitosan generally in the form of tablet, film-former, microsphere and microcapsule served as skeleton materials of release and controlled release preparation.
CONCLUSION: Controlled release preparations developed by chitosan can balance the drug release rate and reduce drug side effects of normal tissue cells.

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