中国组织工程研究

中国组织工程研究 ›› 2011, Vol. 15 ›› Issue (7): 1300-1304.doi: 10.3969/j.issn.1673-8225.2011.07.036

• 组织构建临床实践 clinical practice in tissue construction • 上一篇    下一篇

重组牛碱性成纤维细胞生长因子与胰岛素联合应用治疗压疮创面：随机对照

黄素碧1，易强英2，张杰敏1，杜  励1，赵  会1，林  英1   

  1. 1南充市中心医院骨科，四川省南充市 637000
    2 School of Engineering and Materials Science, Queen Mary, University of London, London E1 4NS
  • 收稿日期:2010-11-22 修回日期:2010-12-24 出版日期:2011-02-12 发布日期:2011-02-12
  • 作者简介:黄素碧，女，1964年生，四川省岳池县人，汉族，副主任护师，主要从事骨科康复护理、压疮预防方面的研究。 hsb556@163. com

Combination of basic fibroblast growth factor and insulin for treatment of pressure sore wounds: A randomized controlled study

Huang Su-bi1, Yi Qiang-ying2, Zhang Jie-min1, Du Li1, Zhao Hui1, Lin Ying1   

  1. 1Department of Orthopedics, Nanchong Central Hospital, Nanchong  637000, Sichuan Province, China
    2School of Engineering and Materials Science, Queen Mary, University of London, London E1 4NS, UK
  • Received:2010-11-22 Revised:2010-12-24 Online:2011-02-12 Published:2011-02-12
  • About author:Huang Su-bi, Associate chief nurse, Department of Orthopedics, Nanchong Central Hospital, Nanchong 637000, Sichuan Province, China hsb556@163.com

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摘要：

背景：长期卧床可导致压疮，促进压疮创面的愈合，缩短压疮的治愈时间是压疮治疗的关键。
目的：观察胰岛素对重组牛碱性成纤维细胞生长因子治疗压疮创面愈合的影响。
方法：选择2009-01/2010-05四川省南充市中心医院收治的压疮病例34例共45处压疮，采用单盲随机分组原则分为实验组和对照组。TDP-L-1-2特定电磁波理疗后，实验组创面加入重组牛碱性成纤维细胞生长因子外用溶液1~3 mL(轻度1 mL，中度2 mL，重度3 mL)+生理盐水3~5 mL(轻度3 mL，中度4 mL，重度5 mL)+胰岛素；对照组不加胰岛素。记录两组治疗两周显效情况和创面愈合时间，并进行对比分析。
结果与结论：实验组治疗有效率、压疮创面治愈时间明显高于对照组(P < 0.05)，但两组患者治疗前血糖浓度差异无显著性意义(P > 0.05)。提示胰岛素的加入可以促进压疮的愈合，而不引起患者血糖浓度的改变。

关键词: 碱性成纤维细胞生长因子, 胰岛素, 压疮, 创面, 血糖

Abstract:

BACKGROUND: Long-term bed results in pressure sore. How to promote the wound healing and shorten the healing time are the essential parts of pressure sore treatment.
OBJECTIVE: To observe the influence of insulin on the treatment of pressure score wounds using bovine basic fibroblast growth factors.
METHODS: The 34 patients (45 pressure sores) of Sichuan Nanchong Central Hospital were divided into the experimental group and control group. In the control group, all the pressure sore wounds were external applied with wet pledget containing basic fibroblast growth factor (1-3 mL) and physiological saline (3-5 mL) after treated with TDP physiotherapy, while the experimental group was treated with the same process except the addition of insulin. The significant condition and wound healing time were recorded in two groups after 2 weeks, and the results were contrastive analyzed.
RESULTS AND CONCLUSION: Efficiency of experimental group was greater than the control group obviously (P < 0.05). But there was no significant difference between two groups in blood glucose concentration before treatment (P > 0.05). The addition of insulin can promote the healing of pressure sores, without the change of blood glucose levels of patients.

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