中国组织工程研究

中国组织工程研究 ›› 2010, Vol. 14 ›› Issue (50): 9437-.doi: 10.3969/j.issn.1673-8225.2010.50.032

• 组织构建学术探讨 • 上一篇    下一篇

脊柱韧带骨化机制的病理学特点

张鑫，贾连顺   

  1. 解放军第二军医大学附属长征医院骨科，上海市 200003
  • 出版日期:2010-12-10 发布日期:2010-12-10
  • 通讯作者: 贾连顺，教授，解放军第二军医大学附属长征医院骨科，上海市 200003 jialianshun@163.com
  • 作者简介:张鑫☆，男，汉族，山东省淄博市人，解放军第二军医大学2005级临床医学八年制本硕博连读生(在读)，主要从事脊柱韧带骨化方面的研究。 czzx86@163.com

Pathological study regarding pathogenesis of spinal ligament ossification

Zhang Xin, Jia Lian-shun   

  1. Department of Orthopaedics, Changzheng Hospital, Second Military Medical University of Chinese PLA, Shanghai  200003, China
  • Online:2010-12-10 Published:2010-12-10
  • Contact: Jia Lian-shun, Professor, Department of Orthopaedics, Changzheng Hospital, Second Military Medical University of Chinese PLA, Shanghai 200003, China jialianshun@163.com
  • About author:Zhang Xin☆, Studying for doctorate, Department of Orthopaedics, Changzheng Hospital, Second Military Medical University of Chinese PLA, Shanghai 200003, China czzx86@163.com

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摘要：

背景：脊柱韧带骨化常造成脊髓受压症，是腰背痛的原因之一。随着影像学的发展和对椎管狭窄症的注意，近年来发现其并非罕见。然而，其确切的发病机制尚未明确。
目的：全面了解脊柱韧带骨化机制的研究现状，归纳总结其相关病理学研究进展，并对其发展趋势做进一步的简要探讨。
方法：以“脊柱、韧带、骨化”为关键词，电子检索主要的中文及英文数据库1999/2009收录的脊柱韧带骨化相关综述和论文报告，排除中文或英文以外的其他语种的文章，提取有关脊柱韧带骨化病理学机制的内容进行归纳总结，并探讨其将来的研究趋势。
结果与结论：共纳入34篇文章。目前研究认为，反复机械应力刺激，元素含量的改变，内分泌与代谢的紊乱，不健康的生活方式与饮食因素及精神分裂症等可能参与了脊柱韧带骨化的发生。许多基础研究结论的提出尚停留于假说的层面，缺乏充足有力的实验证据。对其进一步的研究将集中于阐明各种因素之间的相互作用，从而将疾病的进展阻断于某一阶段，为脊柱韧带骨化的预防及治疗提供完善的理论依据。

关键词: 韧带, 骨化, 病理学, 病因, 脊柱

Abstract:

BACKGROUND: Ossification of the spinal ligament often compresses the spinal cord and is believed to be an important cause of lumbodorsal pain. As the development of iconography and the increasing attention to spinal anal stenosis, it is not uncommon to detect it. However, the pathogenesis has not been conclusively established.
OBJECTIVE: To make an overall understanding of spinal ligament ossification, summarize the relative pathological research and to discuss its research tendency.
METHODS: A literature search was performed using the term “spine, ligament and ossification” for papers published between 1999 and 2009 pertaining to ossification of spinal ligament. Articles published in other languages except Chinese and English were excluded. Contents concerning the pathogenesis of spinal ligament ossification were summarized and the research tendency was discussed. 
RESULTS AND CONCLUSION: A total of 34 articles were finally involved in the final analysis. Currently, repetitive mechanical stress, change of element in body, disturbance of endocrine and metabolism, unhealthy lifestyle, diet and schizophrenia are considered to be involved in the pathogenesis of spinal ligament ossification. However, most of conclusions are hypothesis, which lack of experimental proofs. The further study of spinal ligament ossification focuses on the interactions of various factors, which can provide theoretical basis for prevention and treatment of spinal ligament ossification.

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