中国组织工程研究

中国组织工程研究 ›› 2010, Vol. 14 ›› Issue (50): 9421-.doi: 10.3969/j.issn.1673-8225.2010.50.028

• 组织构建学术探讨 • 上一篇    下一篇

骨桥蛋白与血管重塑

狄柯坪，齐蕊，蒋凤平   

  1. 解放军白求恩军医学院基础部，河北省石家庄市 050081
  • 出版日期:2010-12-10 发布日期:2010-12-10
  • 作者简介:狄柯坪☆，男，辽宁省沈阳市人，汉族，2000年中国医科大学毕业，博士，副教授，主要从事中草药的活血化瘀作用及其分子机制研究。 dikeping77354@126.com

Osteopontin and vascular remodeling

Di Ke-ping, Qi Rui, Jiang Feng-ping    

  1. Department of Basic Courses, Bethune Military Medical College of Chinese PLA, Shijiazhuang  050081, Hebei Province, China
  • Online:2010-12-10 Published:2010-12-10
  • About author:Di Ke-ping☆, Doctor, Associate professor, Department of Basic Courses, Bethune Military Medical College of Chinese PLA, Shijiazhuang 050081, Hebei Province, China dikeping77354@126.com

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被引次数

2

摘要：

背景：骨桥蛋白是细胞外基质中的磷酸化糖蛋白，在骨形成及重建过程中起重要作用，近年来骨桥蛋白在抗炎和损伤修复、血管重塑过程中的作用逐渐引起人们的重视。
目的：综合分析骨桥蛋白在血管重塑中的作用。
方法：计算机检索外文期刊整合服务系统和中国期刊全文数据库中有关骨桥蛋白对血管增殖性疾病影响的文献，并分析其对血管重塑过程的研究进展。
结果与结论: 骨桥蛋白通过其黏附基序与整合素相互作用，调节细胞黏附、迁移、增殖等多种生物学行为，可通过调节血管平滑肌细胞的增殖、分化、黏附、迁移和营养不良性钙化等不同途径调节血管重塑。适度有效地抑制骨桥蛋白的激活将有望成为防治血管增殖性疾病的策略之一。

关键词: 骨桥蛋白, 血管重塑, 血管平滑肌细胞, 表型转化, 增殖, 迁移

Abstract:

BACKGROUND: Osteopontin is a phosphorylation exists in extracellular matrix, which plays an important role in bone formation and remodeling. The effects of osteopontin on anti-inflammatory, and process of injury repair and vascular remodeling has aroused an increasing attention.
OBJECTIVE: To explore the role of osteopontin in the development of vascular remodeling.
METHODS: A computer-based online search was performed to search articles relevant to effect of osteopontin on vascular proliferative diseases, and the research progress of osteopontin on vascular remodeling was analyzed.
RESULTS AND CONCLUSION: Osteopontin can specifically promote adhesion and migration of vascular smooth muscle cells stimulated by biological factors through RGD sequences in different pathway. Osteopontin can also regulate vascular remodeling by inhibiting vessel calcification. Osteopontin can be considered as a target for precaution and therapy of vascular proliferative diseases.

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