中国组织工程研究

中国组织工程研究 ›› 2010, Vol. 14 ›› Issue (23): 4347-4350.doi: 10.3969/j.issn.1673-8225.2010.23.037

• 干细胞学术探讨 stem cell academic discussion • 上一篇    下一篇

创伤性颅脑损伤后的成年神经细胞再生

赵旺淼，郇林春，杨新宇   

  1. 天津医科大学总医院神经外科，天津市神经病学研究所天津市神经损伤变异与再生重点实验室，天津市  300052
  • 出版日期:2010-06-04 发布日期:2010-06-04
  • 通讯作者: 赵旺淼，男，1981年生，河北省衡水市人，汉族，天津医科大学在读硕士，主要从事脑损伤和脑血管病外科治疗方面的研究。 miaomiao_218@163.com
  • 作者简介:赵旺淼，男，1981年生，河北省衡水市人，汉族，天津医科大学在读硕士，主要从事脑损伤和脑血管病外科治疗方面的研究。 miaomiao_218@163.com
  • 基金资助:

    国家自然科学基金资助项目(30973090)
    天津市自然科学基金资助项目(09JCZDJC17200)

Adult neural cell regeneration after traumatic brain injury

Zhao Wang-miao, Huan Lin-chun, Yang Xin-yu   

  1. Department of Neurosurgery, General Hospital, Tianjin Medical University, Key Laboratory of Nerve Injury Variation and Regeneration, Tianjin Neurology Institute, Tianjin  300052, China
  • Online:2010-06-04 Published:2010-06-04
  • Contact: Yang Xin-yu, Doctor, Professor, Master’s supervisor, Department of Neurosurgery, General Hospital, Tianjin Medical University, Key Laboratory of Nerve Injury Variation and Regeneration, Tianjin Neurology Institute, Tianjin 300052, China paperxyyang@gmail.com
  • About author:Zhao Wang-miao, Studying for master’s degree, Department of Neurosurgery, General Hospital, Tianjin Medical University, Key Laboratory of Nerve Injury Variation and Regeneration, Tianjin Neurology Institute, Tianjin 300052, China miaomiao_218@ 163.com
  • Supported by:

    the National Natural Science Foundation of China, No. 30973090;

    the Natural Science Foundation of Tianjin City, No. 09JCZDJC17200*

PDF

305

被引次数

5

摘要：

背景：创伤性颅脑损伤能够导致严重的神经功能障碍。相关研究表明，成年哺乳动物脑内存在持续的内源性神经细胞再生，这可能有助于脑损伤的修复。
目的：综述脑损伤后成年海马、脑室下区和大脑皮质神经细胞再生研究的一些新进展，以便寻找有效手段促进神经细胞再生，修复神经功能。
方法：应用计算机检索PubMed数据库中1998-01/2010-03关于脑损伤后成年神经细胞再生的文章，在标题和摘要中以“Traumatic brain injury; Neurogenesis; Hippocampus; Subventricular zone; Cerebral cortex”为检索词进行检索。选择的神经解剖部位为神经发生区域海马和脑室下区以及非神经发生区域大脑皮质，文章内容与创伤和成年神经细胞再生相关，同一领域文献则选择近期发表或发表在权威杂志文章。初检得到213篇文献，根据纳入标准选择31篇文章进行综述。
结果与结论：成年个体神经系统存在神经细胞再生，适度的创伤能够刺激海马和脑室下区的神经细胞再生，神经细胞再生有助于海马神经功能的修复，一些促进神经细胞再生的外界因素能够改善神经功能。大脑皮质中可能存在处于静息状态的神经前体细胞，在一定条件下，它们可能会再次进入细胞周期从而诱发神经细胞再生，可能对于脑损伤修复有潜在意义。

关键词: 创伤性颅脑损伤, 神经细胞再生, 海马, 脑室下区, 大脑皮质

Abstract:

BACKGROUND: Traumatic brain injury can lead to serious neurological dysfunction. Basal research reveals that persistent endogenous neurogenesis exists in adult mammal brain, which may benefit for recovery of brain trauma.
OBJECTIVE: This article reviews some progresses of neurogenesis in the adult hippocampus, subventricular zone and cerebral cortex after traumatic brain injury to find effective measures to improve neurogenesis and restoration of neurological function.
METHODS: We searched the related articles with respect to adult neurogenesis after traumatic brain injury in Pubmed database, published from January 1998 to March 2010. The key words were “traumatic brain injury, neurogenesis, hippocampus, subventricular zone, cerebral cortex” in title/abstract field. The content of articles was related to trauma and adult neurogenesis, and the study area involves neurogenic region (hippocampus and subventricular zone) and nonneurogenic region cerebral cortex. The articles which are newly issued or published in authoritative magazines were selected. In total 213 articles were included in initial search and 33 articles were selected to review according to inclusion criteria.
RESULTS AND CONCLUSION: Neurogenesis existed in the adult nervous system. Moderate brain trauma could stimulate neurogenesis of hippocampus and subventricular zone, and neurogenesis contributed to restoration of hippocampal function. Some exogenous factors which can promote neurogenesis can also improve neurological function. Resting neural progenitor cells exist in the cerebral cortex. The latent cells will re-entry the cell cycle and induce neurogenesis under certain conditions and they may benefit for the recovery of brain trauma.

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