中国组织工程研究

中国组织工程研究 ›› 2010, Vol. 14 ›› Issue (9): 1685-1688.doi: 10.3969/j.issn.1673-8225.2010.09.039

• 骨与关节学术探讨 • 上一篇    下一篇

不同类型支架材料治疗颅内动脉狭窄：并发症防治及应用进展

杨  磊，黄  斌   

  1. 桂林市人民医院神经外科，广西壮族自治区桂林市  541002
  • 出版日期:2010-02-26 发布日期:2010-02-26
  • 作者简介:杨 磊，男，1973年生，广西壮族自治区桂林市，汉族，广西医科大学毕业，硕士，主治医师，主要从事神经外科临床及研究工作。 i_am_yang@sina.com

Various stent materials for intracranial arteriostenosis: Complication prevention and application development

Yang Lei, Huang Bin   

  1. Department of Neurosurgery, Guilin People’s Hospital, Guilin   541002, Guangxi Zhuang Autonomous Region, China
  • Online:2010-02-26 Published:2010-02-26
  • About author:Yang Lei, Master, Attending physician, Department of Neurosurgery, Guilin People’s Hospital, Guilin 541002, Guangxi Zhuang Autonomous Region, China i_am_yang@sina.com

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摘要：

目的：探讨不同类型支架材料治疗颅内动脉狭窄治疗效果及并发症防治情况。
方法：应用计算机应用计算机检索Science Direct 数据库、Ei数据库1998-01/2009-10期间的相关文章，检索词为“intracranial arteriostenosis，stent placement”，并限定文章语言种类为English。同时计算机检索中国期刊全文数据库、中国生物医学文献数据库等1998-01/2009-10期间的相关文章，检索词为“颅内动脉狭窄，支架置入”，并限定文章语言种类为中文。此外还手工查阅相关专著数部。纳入不同支架置入治疗颅内动脉狭窄的研究，包括基础与临床实验。
结果：从目前世界范围内的多中心研究结果看，颈动脉狭窄的支架置入治疗较颈动脉内膜剥脱有明显的优势。近年来，随着球囊和支架柔顺性的改进及支架技术的发展，各种新型材料及脑保护伞的应用，支架治疗颅内动脉狭窄已逐渐成为一种安全有效的方法，血管内支架已成为治疗颅内动脉狭窄相对安全有效的新途径。但支架置入治疗后会发生不同并发症如再狭窄、缺血性脑卒中、脑出血高灌注综合征、脑血管痉挛等。
结论：颅内动脉支架置入治疗安全性和有效性还缺乏多中心前瞻性研究的支持。支架置入治疗术后较高的再狭窄率尚无很有效办法，有待支架材料的进一步发展。

关键词: 支架材料, 医学植入物, 颅内动脉狭窄, 并发症, 生物材料

Abstract:

OBJECTIVE: To explore the treatment effect and complication prevention of various stent materials for intracranial arteriostenosis.
METHODS: A computer-based online search of Science Direct and Ei database (1998-01/2009-10) was performed for English articles with the key words of “intracranial arteriostenosis, stent placement”. In addition, CNKI and CBM database (1998-01/2009-10) were searched for related Chinese articles with the same key words in Chinese. Moreover, related works were manually searched. Studies regarding various stent materials for intracranial arteriostenosis were included, including basic and clinical experiments.
RESULTS: Multicenter studies of worldwide show that stent implantation displays obvious advantages in treating carotid artery stenosis compared with carotid endarterectomy. Recently, with developing of balloon and stent compliance, as well as stent technology, and application of various novel materials and cerebral protection device, stent has become a safe and effective therapy for intracranial arteriostenosis. However, complications following stent implantation, such as restenosis, ischemic stroke, cerebral hemorrhage hypertransfusion syndrome, and cerebral angiospasm, limit its application.
CONCLUSION: The safety and efficacy of intracranial stent implantation remains validation of multicenter and perspective studies. High incidence of restenosis following stent implantation requires further improvement.

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