中国组织工程研究

中国组织工程研究 ›› 2010, Vol. 14 ›› Issue (3): 533-536.doi: 10.3969/j.issn.1673-8225.2010.03.037

• 生物材料学术探讨 biomaterial academic discussion • 上一篇    下一篇

藻酸盐敷料的临床应用：与传统材料特征的比较

王清华，钟文菲，何  盟   

  1. 海南省人民医院肿瘤外科，海南省海口市  570311
  • 出版日期:2010-01-15 发布日期:2010-01-15
  • 作者简介:王清华，女，1974年生，主管护师，造口治疗师，护士长。wangqinghua.1974@yahoo.com.cn

Clinical application of alginate dressing: A comparison with traditional materials

Wang Qing-hua, Zhong Wen-fei, He Men   

  1. Department of Tumor Surgery, Hainan Provincial People’s Hospital, Haikou   570311, Hainan Province, China
  • Online:2010-01-15 Published:2010-01-15
  • About author:Wang Qing-hua, Nurse-in-charge, Department of Tumor Surgery, Hainan Provincial People’s Hospital, Haikou 570311, Hainan Province, China wangqinghua.1974@yahoo.com.cn

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摘要：

目的：对澡酸盐敷料的特性及临床应用进行探讨，以期为临床创面愈合提供更好的生物敷料。
方法：由第一作者应用计算机检索中国期刊全文数据库、Medline数据库、万方数据库、Science Direct 数据库、Ei数据库1960-01/2009-10期间相关文献，检索词为“澡酸盐，敷料，临床应用，dressing，alginate”，纳入澡酸盐特性及临床应用方面的研究，排除重复及Meta分析类文献。并手工查阅相关书籍。
结果：共检索到65篇相关文献，17篇文献符合纳入标准，排除的48篇文献为重复或Meta分析。藻酸盐是由海带中提取的天然多糖碳水化合物，而藻酸盐敷料是从海藻中提炼的柔软无纺织纤维，它含有85%天然藻酸盐纤维，15%的羧甲基纤维素纳。它的主要功能是吸收渗出液，形成凝胶，与渗液发生Na+ /Ca 2+离子交换。藻酸盐敷料的出现，为患者带来了福音，目前在压疮的处理、肛瘘的护理、造口护理、糖尿病足护理等方面都得到了广泛的临床应用。与传统敷料比较，藻酸盐敷料感染率较低，其原因，一是其密闭性好，与外界隔绝；二是可促进局部血管增生，增加血液供应，治疗效果显著提高；三是潮湿、微酸环境有利于中性粒细胞发挥作用，增强局部杀菌能力，降低感染发生率。这类材料还可用于腹部手术术后伤口愈合，脓肿切开引流术后伤口的应用等。
结论：澡酸盐湿性敷料可以提供最适宜伤口生长的湿润环境,保留渗出液中的活性物质并促进活性物质的释放,有利于坏死组织的溶解和组织细胞的增殖分化及上皮细胞的移行; 同时使伤口内微循环保持低氧状态,刺激新生毛细血管的生长 ,促进肉芽组织的生长。

关键词: 藻酸盐敷料, 临床应用, 生物材料, 湿性敷料, 创面愈合

Abstract:

OBJECTIVE: To explore the characteristics and clinical application of alginate dressing to provide better biological dressing for clinical wound healing.
METHODS: A computer-based online search of CNKI, Medline, Wanfang, Science Direct, and Ei databases was performed for related articles published between January 1960 and October 2009, with the key words “alginate, dressing, clinical application” in Chinese and English. Studies regarding characteristics and clinical application of alginate dressing were included. Repetitive and Meta analysis were excluded. In addition, related books were manually searched.
RESULTS: A total of 65 articles were collected, 17 were included, and 48 repetitive or Meta analyses were excluded. Alginate is natural polysaccharide carbohydrate extracted from sea tangle, and alginate dressing is soft non-textile fiber refined from seaweed. It contains 85% natural alginate fiber and 15% sodium tvlose. It can absorb effusion, form gelate, and exchange Na+ /Ca 2+ with effusion. Alginate dressing has been widely used in bedsore treatment, anal fistula nursing, stoma nursing, and diabetic foot nursing. Compared with traditional dressing, infection rate of alginate dressing is lower due to good impermeability, promotion of regional vessel proliferation and blood supply, as well as moist and slightly acidic environment which benefits neutrophil function enhances disinfection. Moreover, it can be used in wound healing following abdominal region operation and abscess incision drainage.
CONCLUSION: Alginate dressing provides appropriate environment for wound growth, retains active materials in diffusion, promotes active material release, benefit necrotic tissue solution and cell proliferation and differentiation, as well as epithelial cell migration. Moreover, it maintains hypoxia state of wound, stimulates newly generated capillary growth, and promotes granulation tissue growth.

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