中国组织工程研究

中国组织工程研究 ›› 2024, Vol. 28 ›› Issue (15): 2404-2409.doi: 10.12307/2024.378

• 生物材料综述 biomaterial review • 上一篇    下一篇

软骨支架材料的制备方法及优缺点

王泽文1，李陈致1，刘家河1，李炎城1，吴铭健1，崔  焱1，李振豪1，熊婉琦1，何  挺1，刘保一1，杨  帆1，2   

  1. 1大连大学附属中山医院，辽宁省大连市  116001；2中国科学院金属研究所，辽宁省沈阳市  110000
  • 收稿日期:2023-05-08 接受日期:2023-07-04 出版日期:2024-05-28 发布日期:2023-09-23
  • 通讯作者: 刘保一，博士，主任医师，大连大学附属中山医院，辽宁省大连市 116001 杨帆，博士，副研究员，大连大学附属中山医院骨科，辽宁省大连市 116001；中国科学院金属研究所，辽宁省沈阳市 110000
  • 作者简介:王泽文，男，1998年生，山东省烟台市人，汉族，大连大学在读硕士，主要从事创伤骨科、软骨损伤、骨坏死等研究。
  • 基金资助:
    大连市博士后科学基金项目(285395)，项目负责人：杨帆；大连医学科学研究项目(2111038)，项目负责人：杨帆；辽宁省教育厅重点公关项目(LJKZZ20220148)，项目负责人：刘保一

Preparation methods, advantages, and disadvantages of cartilage scaffold materials

Wang Zewen1, Li Chenzhi1, Liu Jiahe1, Li Yancheng1, Wu Mingjian1, Cui Yan1, Li Zhenhao1, Xiong Wanqi1, He Ting1, Liu Baoyi1, Yang Fan1, 2   

  1. 1Zhongshan Hospital Affiliated to Dalian University, Dalian 116001, Liaoning Province, China; 2Institute of Metal Research, Chinese Academy of Sciences, Shenyang 110000, Liaoning Province, China
  • Received:2023-05-08 Accepted:2023-07-04 Online:2024-05-28 Published:2023-09-23
  • Contact: Liu Baoyi, PhD, Chief physician, Zhongshan Hospital Affiliated to Dalian University, Dalian 116001, Liaoning Province, China Yang Fan, PhD, Associate researcher, Zhongshan Hospital Affiliated to Dalian University, Dalian 116001, Liaoning Province, China; Institute of Metal Research, Chinese Academy of Sciences, Shenyang 110000, Liaoning Province, China
  • About author:Wang Zewen, Master candidate, Zhongshan Hospital Affiliated to Dalian University, Dalian 116001, Liaoning Province, China
  • Supported by:
    Postdoctoral Science Foundation of Dalian, No. 285395 (to YF); Dalian Medical Science Research Project, No. 2111038 (to YF); Key Research Project of Education Department of Liaoning Province, No. LJKZZ20220148 (to LBY)

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摘要：


文题释义：

软骨支架材料：一种用于辅助软骨修复的材料，它能够支撑细胞的生长和分化、促进软骨组织的再生。支架材料通常由天然或合成聚合物制成，具有良好的生物相容性和力学性能，能够模拟天然细胞外基质的结构和功能。
软骨组织工程：是一种新兴的技术，它将软骨细胞、信号刺激及支架材料有机整合，提高其整体的生物化学与生物机械能力，利用固定技术使之能更好地充填缺损，为修复软骨损伤提供一种可能。


背景：软骨组织工程支架材料是提供空间和结构的平台，对软骨组织的再生至关重要，国内外学者均在尝试采用不同方式制备更理想的软骨组织工程支架材料。

目的：综述软骨支架材料的设计原则和制备方式，并进一步探讨各种制备方法的优缺点。
方法：应用计算机检索中国知网、万方、PubMed和FMRS数据库1998-2023年发表的与软骨组织工程中支架材料有关的文献，中文检索词包括“软骨修复，软骨组织工程，软骨支架材料，制备方法”，英文检索词包括“Cartilage repair，cartilage tissue engineering，cartilage scaffold materials， preparation”，最终选择57篇文献进行综述。

结果与结论：①关节软骨结构特殊，其损伤后的自我修复能力较差，即使发生自我修复其新生的软骨通常为纤维软骨，无论是结构还是力学性能都远远不如正常关节软骨，难以维系正常的功能，通常很快就会发生退行性病变。目前设计制备软骨修复的支架材料需要考虑以下内容：生物相容性和生物降解性、适宜的孔隙结构和孔隙率、合适的力学性能及生物活性。②软骨支架制备的研究取得了显著进展，不断涌现出新的制备方法和优化策略，这些方法各有优劣，可以根据具体需求选择合适的方法为软骨支架的定制化制备和功能性设计提供了更多可能性。

https://orcid.org/0009-0005-2856-7660(王泽文)

中国组织工程研究杂志出版内容重点：生物材料；骨生物材料；口腔生物材料；纳米材料；缓释材料；材料相容性；组织工程

关键词: 软骨损伤, 软骨修复, 软骨组织工程, 软骨支架材料, 软骨支架材料设计, 软骨支架材料制备

Abstract: BACKGROUND: Scaffold materials serve as platforms that provide space and structure, playing a crucial role in the regeneration of cartilage tissue. Scholars from around the world are exploring different approaches to fabricate more ideal scaffold materials.
OBJECTIVE: To review the design principles and preparation methods of cartilage scaffolds, and to further explore the advantages and limitations of various preparation methods. 
METHODS: Literature searches were conducted on the databases of CNKI, WanFang Data, PubMed, and FMRS from 1998 to 2023. The search terms were “cartilage repair, cartilage tissue engineering, cartilage scaffold materials, preparation” in Chinese and English. A total of 57 articles were ultimately reviewed.
RESULTS AND CONCLUSION: (1) The articular cartilage has a unique structure and limited self-repair capacity after injury. Even if self-repair occurs, the newly formed cartilage is typically fibrocartilage, which is far inferior to normal articular cartilage in terms of structure and mechanical properties. It is difficult to maintain normal function and often leads to degenerative changes. Currently, the design and fabrication of scaffold materials for cartilage repair need to consider the following aspects: biocompatibility and biodegradability, suitable pore structure and porosity, appropriate mechanical properties, and bioactivity. (2) Research on the preparation of cartilage scaffolds has made significant progress, continuously introducing new preparation methods and optimization strategies. These methods have their advantages and disadvantages, providing more possibilities for customized preparation and functional design of cartilage scaffolds according to specific requirements. 

Key words: tissue injury, cartilage repair, cartilage tissue engineering, cartilage scaffold material, cartilage scaffold material design, cartilage scaffold material preparation

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