中国组织工程研究

中国组织工程研究 ›› 2024, Vol. 28 ›› Issue (15): 2410-2415.doi: 10.12307/2024.411

• 生物材料综述 biomaterial review • 上一篇    下一篇

纳米复合水凝胶在骨关节炎治疗中的优势与特征

田林灵1，郭海瑞1，杜晓明1，冯   杰1，张宪哲1，张文彬1，孙浩然1 ，张晓彬2 ，王静霞2 ，胡一梅1，3 ，王   毅4   

  1. 1成都中医药大学，四川省成都市  6100414；2四川省原子能研究院，四川省成都市  610199；3成都中医药大学附属医院，四川省成都市 610041；4西南交通大学，四川省成都市  610031
  • 收稿日期:2023-05-30 接受日期:2023-07-17 出版日期:2024-05-28 发布日期:2023-09-23
  • 通讯作者: 胡一梅，博士，教授，硕士生导师，成都中医药大学，四川省成都市 6100414；成都中医药大学附属医院，四川省成都市 610041 王毅，博士，教授，硕士生导师，西南交通大学，四川省成都市 610031
  • 作者简介:田林灵，女，1991年生，四川省成都市人，汉族，成都中医药大学临床医学院在读硕士，主要从事骨坏死及关节退行性病变的中医药临床研究。
  • 基金资助:
    国家自然科学基金(325021015)，项目负责人：胡一梅；成都中医药大学科技处(030058047，030038164)，项目负责人：胡一梅；成都中医药大学附属医院科研能力提升“百人计划”(22-B07)，项目负责人：胡一梅；四川省科技厅国际合作项目(2020YFH0052)，项目负责人：王毅；中央高校基本科研业务费项目(2682022ZTPY038)，项目负责人：王毅

Advantages and features of nanocomposite hydrogel in treatment of osteoarthritis

Tian Linling1, Guo Hairui1, Du Xiaoming1, Feng Jie1, Zhang Xianzhe1, Zhang Wenbin1, Sun Haoran1, Zhang Xiaobin2, Wang Jingxia2, Hu Yimei1, 3, Wang Yi4   

  1. 1Chengdu University of Traditional Chinese Medicine, Chengdu 610041, Sichuan Province, China; 2Sichuan Atomic Energy Research Institute, Chengdu 610199, Sichuan Province, China; 3Affiliated Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu 610041, Sichuan Province, China; 4Southwest Jiaotong University, Chengdu 610031, Sichuan Province, China
  • Received:2023-05-30 Accepted:2023-07-17 Online:2024-05-28 Published:2023-09-23
  • Contact: Hu Yimei, PhD, Professor, Master’s supervisor, Chengdu University of Traditional Chinese Medicine, Chengdu 610041, Sichuan Province, China; Affiliated Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu 610041, Sichuan Province, China Wang Yi, PhD, Professor, Master’s supervisor, Southwest Jiaotong University, Chengdu 610031, Sichuan Province, China
  • About author:Tian Linling, Master candidate, Chengdu University of Traditional Chinese Medicine, Chengdu 610041, Sichuan Province, China
  • Supported by:
    National Natural Science Foundation of China, No. 325021015 (to HYM); Science and Technology Department of Chengdu University of Traditional Chinese Medicine, Nos. 030058047, 030038164 (to HYM); “Hundred Talents Plan” for Improving the Scientific Research Ability of the Affiliated Hospital of Chengdu University of Traditional Chinese Medicine, No. 22-B07 (to HYM); International Cooperation Project of Sichuan Provincial Department of Science and Technology, No. 2020YFH0052 (to WY); Central University Basic Research Business Fee Project, No. 2682022ZTPY038 (to WY)

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摘要：


文题释义：

纳米复合水凝胶：纳米颗粒与水凝胶交联形成具有三维网络结构的材料，具有较传统水凝胶更强的化学、物理或生物学特性。
骨关节炎：是中老年人群中高发的一种慢性进展性疾病，主要表现为关节软骨破坏的继发关节内炎症，临床上骨关节炎的早期多表现为弥漫的、大小深浅不一的软骨浅表缺损。骨关节炎的发病机制复杂，病理过程涉及多种细胞因子、炎症递质以及信号通路的分泌与激活，最终导致关节软骨破坏。


背景：纳米复合水凝胶在骨关节炎治疗中有很大的研究前景和应用潜力。

目的：综述纳米复合水凝胶在骨关节炎及软骨修复中的研究进展。
方法：检索中国知网和PubMed 等数据库，英文检索词为“nanocomposite hydrogel，nanogel，osteoarthritis，cartilage，physical encapsulation，electrostatic interaction，covalent crosslinking”，中文检索词为“纳米复合水凝胶，纳米水凝胶，骨关节炎，软骨，物理包覆，物理包载，静电作用，共价交联”。根据纳入与排除标准对所有文章进行初筛后，保留相关性较高的71篇文章进行综述。

结果与结论：在细胞或动物实验中，纳米复合水凝胶具有改善骨关节炎的效果。纳米复合水凝胶可以从改善关节间力学环境、搭载靶向药物、促进种子细胞软骨化等方面加速软骨修复，改善骨关节炎症内环境，达到治疗骨关节炎的目的。目前纳米复合水凝胶在骨关节炎疾病中的研究仍有巨大的发挥空间，继续深入材料制备研究，积极开展细胞、动物实验将有望为临床治疗骨关节炎开辟新途径。

https://orcid.org/0009-0007-6399-9092(田林灵)

中国组织工程研究杂志出版内容重点：生物材料；骨生物材料；口腔生物材料；纳米材料；缓释材料；材料相容性；组织工程

关键词: 骨关节炎, 软骨修复, 软骨组织工程, 纳米复合水凝胶, 生物材料, 生物支架, 软骨支架, 综述

Abstract: BACKGROUND: Nanocomposite hydrogel has great research prospects and application potential in the treatment of osteoarthritis.
OBJECTIVE: To review the research progress of nanocomposite hydrogel in osteoarthritis and cartilage repair.
METHODS: Databases such as CNKI and PubMed were searched. The English key words were “nanocomposite hydrogel, nanogel, osteoarthritis, cartage, physical encapsulation, electrostatic interaction, covalent crosslinking”, and the Chinese key words were “nanocomposite hydrogel, nanogel, osteoarthritis, cartage, physical encapsulation, physical encapsulation, electrostatic effect, covalent cross-linking”. After an initial screening of all articles based on inclusion and exclusion criteria, 71 articles with high correlation were retained for review.
RESULTS AND CONCLUSION: In cell or animal experiments, nanocomposite hydrogel has the effect of improving osteoarthritis. Nanocomposite hydrogel can promote cartilage repair, improve the internal environment of osteoarthritis, and achieve the therapeutic purpose of osteoarthritis by improving the mechanical environment between joints, carrying targeted drugs, and promoting the chondrogenesis of seed cells. At present, the research of nanocomposite hydrogel in osteoarthritis disease still has a huge space to play. It is expected to open up a new way for the clinical treatment of osteoarthritis by continuing to deepen the research of material preparation and actively carrying out cell and animal experiments.

Key words: osteoarthritis, cartilage repair, cartilage tissue engineering, nanocomposite hydrogel, biomaterial, biological scaffold, cartilage scaffold, review

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