中国组织工程研究 ›› 2024, Vol. 28 ›› Issue (25): 4094-4100.doi: 10.12307/2024.198

• 干细胞综述 stem cell review • 上一篇    

骨骼肌中卫星细胞衰老生物学机制及潜在的应对策略

解瑛傲1,孔健达2,陈  芸3,李志林2,徐  鹏3   

  1. 1济宁医学院,山东省济宁市   272000;2曲阜师范大学体育科学学院,山东省济宁市   272000;3济宁医学院附属医院,山东省济宁市   272000
  • 收稿日期:2023-08-07 接受日期:2023-09-09 出版日期:2024-09-08 发布日期:2023-11-24
  • 通讯作者: 陈芸,硕士,副主任医师,济宁医学院附属医院,山东省济宁市 272000
  • 作者简介:解瑛傲,女,1999年生,济宁医学院在读硕士,山东省青岛市人,汉族,主要从事神经肌肉疾病临床治疗与机制的研究。
  • 基金资助:
    济宁市重点研发计划项目(2021YXNS103),项目负责人:徐鹏

Biological mechanism of satellite cell aging in skeletal muscles and potential coping strategies

Xie Yingao1, Kong Jianda2, Chen Yun3, Li Zhilin2, Xu Peng3   

  1. 1Jining Medical University, Jining 272000, Shandong Province, China; 2School of Physical Education Science, Qufu Normal University, Jining 272000, Shandong Province, China; 3Affiliated Hospital of Jining Medical University, Jining 272000, Shandong Province, China
  • Received:2023-08-07 Accepted:2023-09-09 Online:2024-09-08 Published:2023-11-24
  • Contact: Chen Yun, Master, Associate chief physician, Affiliated Hospital of Jining Medical University, Jining 272000, Shandong Province, China
  • About author:Xie Yingao, Master candidate, Jining Medical University, Jining 272000, Shandong Province, China
  • Supported by:
    Key Research & Development Plan Project in Jining City, No. 2021YXNS103 (to XP)

摘要:


文题释义:

卫星细胞:神经胶质细胞的一种,是神经节内包囊神经元胞体的一层扁平或立方形细胞,其细胞核为圆形或卵圆形,染色较深,细胞外面有一层基膜。
衰老:指机体对环境的生理和心理适应能力进行性降低及逐渐趋向死亡的现象。


背景:卫星细胞是一种肌源性干细胞,位于肌纤维膜与基底膜之间,但尚未有综述完全揭示卫星细胞衰老机制及其潜在应对策略,这对于当前减缓骨骼肌老化的策略应用难以起到有效的指导效果。

目的:综述骨骼肌中卫星细胞衰老的机制及其相关减缓其衰老的应对策略。
方法:检索各数据库时间截至2023年5月,包括Web of Science、PubMed、中国知网、万方和维普数据库。英文检索词:“Skeletal muscle,satellite cells,aging,mechanism,solution strategye”;中文检索词:“骨骼肌,卫星细胞,衰老,老化,机制,应对策略”。经过严格按照纳入和排除标准进行筛选,最终纳入78篇文献进行综述分析。

结果与结论:①卫星细胞位于肌纤维膜与基底膜之间,具有增殖和分化潜能,通常处于静息状态,但在肌肉组织受刺激时会被激活并参与修复和恢复正常组织结构的过程,衰老会导致卫星细胞数量减少,并引发肌力和耐力的下降等症状。②卫星细胞衰老的机制主要涉及再生能力下降、串扰能力随生态位变化、年龄依赖性损失和异质性变化,衰老的卫星细胞数量减少以及活性降低会导致肌肉再生速度变慢和损伤恢复时间增加,且在分化过程中可能出现错误,从而导致肌肉质量下降和功能退化。③针对卫星细胞衰老的应对策略主要包括调节体内卫星细胞的受体环境、外源手段干预促进卫星细胞再生、人体肌肉模型构建和运动和饮食干预诱导卫星细胞增殖等,这些策略具有一定的潜力,可以为卫星细胞的再生和治疗骨骼肌疾病提供新的思路和方法。④未来的研究建议深入探究卫星细胞衰老机制,探究卫星细胞与生态位之间的相互作用,研究卫星细胞与免疫系统和线粒体功能等因素的关系,开发应用人体肌肉模型来提高研究深度和准确性。

https://orcid.org/0009-0005-0223-7532 (解瑛傲);https://orcid.org/0009-0004-7000-7694 (陈芸) 

中国组织工程研究杂志出版内容重点:干细胞;骨髓干细胞;造血干细胞;脂肪干细胞;肿瘤干细胞;胚胎干细胞;脐带脐血干细胞;干细胞诱导;干细胞分化;组织工程

关键词: 骨骼肌, 卫星细胞, 衰老, 生物学机制, 修复, 干细胞, 再生能力, 自我更新, 应对策略

Abstract: BACKGROUND: Satellite cells are myogenic stem cells located between the muscle fiber membrane and the basement membrane. However, a comprehensive review of the aging mechanisms of satellite cells and their potential mitigation strategies is still lacking. This gap in knowledge hinders the effective guidance for current strategies aimed at attenuating skeletal muscle aging.
OBJECTIVE: To review the mechanisms of satellite cell aging in skeletal muscle and the relevant strategies for mitigating this aging process.
METHODS: Major databases were searched up to May 2023, including Web of Science, PubMed, China National Knowledge Infrastructure (CNKI), WanFang Data, and VIP. Chinese and English search terms included “skeletal muscle, satellite cells, aging, mechanism, and solution strategy”. After strict inclusion and exclusion criteria were applied, 78 articles were finally included.
RESULTS AND CONCLUSION: (1) Satellite cells, situated between the muscle fiber membrane and basement membrane, possess proliferative and differentiative potential. They usually remain in a quiescent state but become activated in response to muscle tissue stimuli, participating in processes of repair and restoration of normal tissue structure. Aging leads to a reduction in satellite cell numbers, resulting in symptoms such as muscle weakness and decreased endurance. (2) Mechanisms of satellite cell aging primarily involve diminished regenerative capacity, perturbed niche interactions with changing ecology, age-dependent loss, and heterogeneity changes. Reduced satellite cell numbers and activity due to aging lead to slower muscle regeneration and increased injury recovery time. Errors during differentiation may occur, resulting in decreased muscle quality and function deterioration. (3) Strategies for mitigating satellite cell aging encompass modulation of the receptor environment of intra-body satellite cells, peripheral interventions to promote satellite cell regeneration, construction of human muscle models, and exercise and nutritional interventions to induce satellite cell proliferation. These strategies hold promise in offering novel insights and methods for satellite cell regeneration and treatment of skeletal muscle diseases. (4) Future research should delve into the mechanisms of satellite cell aging, explore the interaction between satellite cells and their niches, investigate the relationship of satellite cells with the immune system and mitochondrial function, and develop human muscle models to enhance research depth and accuracy.

Key words: skeletal muscle, satellite cell, aging, biological mechanism, repair, stem cell, regenerative capacity, self-renewal, solution strategy

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