中国组织工程研究 ›› 2023, Vol. 27 ›› Issue (15): 2404-2411.doi: 10.12307/2023.362
• 干细胞综述 stem cell review • 上一篇 下一篇
李 炜1,蔺美娜2,卢永平2,隋 钰2,姜 淼1,2
收稿日期:
2022-05-05
接受日期:
2022-06-23
出版日期:
2023-05-28
发布日期:
2022-10-18
通讯作者:
姜淼,硕士,研究员,沈阳体育学院,辽宁省沈阳市 110115;国家卫健委生殖健康与医学遗传学重点实验室(中国医科大学)&辽宁生殖健康重点实验室,辽宁省计划生育科学研究院,中国医科大学附属生殖医院优生遗传科,辽宁省沈阳市 110031
作者简介:
李炜,男,1997年生,山东省泰安市人,汉族,2020年沈阳体育学院毕业,主要从事运动损伤的预防与康复研究。
基金资助:
Li Wei1, Lin Meina2, Lu Yongping2, Sui Yu2, Jiang Miao1, 2
Received:
2022-05-05
Accepted:
2022-06-23
Online:
2023-05-28
Published:
2022-10-18
Contact:
Jiang Miao, Master, Researcher, Shenyang Sport University, Shenyang 110115, Liaoning Province, China; NHC Key Laboratory of Reproductive Health and Medical Genetics (China Medical University) & Liaoning Key Laboratory of Reproductive Health, Liaoning Research Institute of Family Planning, Department of Eugenics and Genetics, Reproductive Hospital Affiliated to China Medical University, Shenyang 110031, Liaoning Province, China
About author:
Li Wei, Shenyang Sport University, Shenyang 110115, Liaoning Province, China
Supported by:
摘要:
文题释义:
间充质干细胞:是源于中胚层的一类多能干细胞,具有自我更新和多向分化能力,可从骨髓、脂肪、肌腱、脐带、肌肉、子宫内膜、羊水、牙周等组织中分离,在特定条件下可分化为脂肪、骨、软骨等多种细胞。
生物医用材料:通过特定的方法加工处理以用于和活组织接触并对疾病进行治疗或诱导组织再生的一类天然或人工合成的生物材料。
背景:跟腱是运动中较为常见的损伤部位,尤其在过量或不当运动中更易受累,且损伤后难以恢复。寻找安全、有效、快速的修复方法,一直是跟腱损伤临床治疗的努力方向,但是效果并不理想。近年来间充质干细胞因其强大的修复潜能被尝试用于多种疾病的治疗,也有部分研究将间充质干细胞应用于跟腱损伤的修复,具有良好的效果。
目的:总结了骨髓、脂肪及肌腱等多种组织来源间充质干细胞在跟腱损伤中的应用,探讨间充质干细胞治疗跟腱损伤的可行性及优势,为治疗跟腱损伤提供新思路。
方法:通过检索CNKI数据库、万方数据库、百度学术数据库、Web of Science数据库、PubMed数据库、Google学术数据库收录的文献,英文检索词为“achilles tendon,achilles tendon injury,achilles tendon rupture,stem cells,mesenchymal stem cells,MSCs,biological materials,tissue engineering”,中文检索词为“跟腱,跟腱损伤,跟腱断裂,干细胞,间充质干细胞,生物材料,组织工程”。对筛选的文献进行整理归纳,排除不符合纳入标准的文献,最终选择101篇文献进行综述。
结果与结论:不同组织来源的间充质干细胞独立应用或者联合生物材料应用,均有利于跟腱的损伤修复,但是其中涉及的具体机制还不是很清楚,可能包括间充质干细胞向腱细胞分化、调节生长因子释放及肌腱相关基因的表达等。寻找最适合跟腱损伤治疗的种子细胞和生物材料是跟腱组织工程修复的关键。
https://orcid.org/0000-0002-3122-8388 (姜淼)
中国组织工程研究杂志出版内容重点:干细胞;骨髓干细胞;造血干细胞;脂肪干细胞;肿瘤干细胞;胚胎干细胞;脐带脐血干细胞;干细胞诱导;干细胞分化;组织工程
中图分类号:
李 炜, 蔺美娜, 卢永平, 隋 钰, 姜 淼. 间充质干细胞修复跟腱损伤的可行性与优势[J]. 中国组织工程研究, 2023, 27(15): 2404-2411.
Li Wei, Lin Meina, Lu Yongping, Sui Yu, Jiang Miao. Feasibility and advantages of mesenchymal stem cells for repairing Achilles tendon injury[J]. Chinese Journal of Tissue Engineering Research, 2023, 27(15): 2404-2411.
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1.1.6 检索策略 以PubMed数据库和CNKI数据库为例,文献检索策略见表1。
1.1.7 检索文献量 检索文献量为3 827篇,其中中文1 061篇,英文2 766篇。
1.3 质量评估 选取与综述主题密切相关的文章,排除重复性、数据不可靠、研究质量较差的文章3 726篇,最终纳入101篇文献,其中中文文献12篇,英文文献89篇。文献筛选流程见图1。
文题释义:#br# 间充质干细胞:是源于中胚层的一类多能干细胞,具有自我更新和多向分化能力,可从骨髓、脂肪、肌腱、脐带、肌肉、子宫内膜、羊水、牙周等组织中分离,在特定条件下可分化为脂肪、骨、软骨等多种细胞。#br# 生物医用材料:通过特定的方法加工处理以用于和活组织接触并对疾病进行治疗或诱导组织再生的一类天然或人工合成的生物材料。#br# 中国组织工程研究杂志出版内容重点:干细胞;骨髓干细胞;造血干细胞;脂肪干细胞;肿瘤干细胞;胚胎干细胞;脐带脐血干细胞;干细胞诱导;干细胞分化;组织工程
随着再生医学的发展,干细胞受到国内外众多学者的关注,有望在创伤修复及疾病治疗中发挥重要作用。跟腱损伤作为一种可影响患者日常生活质量的疾病,在恢复后常伴随着生物力学性能下降及细胞外基质组分等的异常改变。干细胞疗法为跟腱损伤后的修复提供了一种方法。目前,应用间充质干细胞治疗跟腱损伤的研究较多,在促进肌腱相关基因的表达、维持细胞外基质组分稳定等方面有显而易见的作用。
中国组织工程研究杂志出版内容重点:干细胞;骨髓干细胞;造血干细胞;脂肪干细胞;肿瘤干细胞;胚胎干细胞;脐带脐血干细胞;干细胞诱导;干细胞分化;组织工程
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