中国组织工程研究 ›› 2023, Vol. 27 ›› Issue (21): 3430-3437.doi: 10.12307/2023.131
• 生物材料综述 biomaterial review • 上一篇 下一篇
申 勇1,刘时璋2
收稿日期:
2022-04-01
接受日期:
2022-05-11
出版日期:
2023-07-28
发布日期:
2022-11-26
通讯作者:
刘时璋,博士,硕士生导师,主任医师,教授,陕西省人民医院骨科,陕西省西安市 710068
作者简介:
申勇,男,1996年生,陕西省渭南市人,汉族,西安医学院在读硕士,主要从事医用钛合金抗菌性能及生物相容性研究。
基金资助:
Shen Yong1, Liu Shizhang2
Received:
2022-04-01
Accepted:
2022-05-11
Online:
2023-07-28
Published:
2022-11-26
Contact:
Liu Shizhang, MD, Master’s supervisor, Chief physician, Professor, Department of Orthopedics, Shaanxi Provincial People’s Hospital, Xi’an 710068, Shaanxi Province, China
About author:
Shen Yong, Master candidate, Xi’an Medical College, Xi’an 710021, Shaanxi Province, China
Supported by:
摘要:
文题释义:
医用钛合金:用于制造植入人体内的医疗器件、假体、辅助治疗设备的钛合金,生物力学性能接近人骨,还具备耐疲劳、耐腐蚀及良好的生物相容性等优势。中图分类号:
申 勇, 刘时璋. 医用含铜钛合金抗菌性能的研究与进展[J]. 中国组织工程研究, 2023, 27(21): 3430-3437.
Shen Yong, Liu Shizhang. Research progress on antibacterial properties of medical copper-containing titanium alloys[J]. Chinese Journal of Tissue Engineering Research, 2023, 27(21): 3430-3437.
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Fabrication of low-cost beta-type Ti-Mn alloys for biomedical applications by metal injection molding process and their mechanical properties. J Mech Behav Biomed Mater. 2016;59:497-507. [50] ALQATTAN M, PETERS L, ALSHAMMARI Y, et al. Antibacterial Ti-Mn-Cu alloys for biomedical applications. Regen Biomater. 2021;8(1):rbaa050. [51] ALSHAMMARI Y, YANG F, BOLZONI L. Mechanical properties and microstructure of Ti-Mn alloys produced via powder metallurgy for biomedical applications. J Mech Behav Biomed Mater. 2019;91:391-397. [52] LI HF, QIU K J, ZHOU F Y, et al. Design and development of novel antibacterial Ti-Ni-Cu shape memory alloys for biomedical application. Sci Rep. 2016;6:37475. [53] ZHAO QM, LI B, YU FX, et al. Cu-Co Co-Doped Microporous Coating on Titanium with Osteogenic and Antibacterial Properties. J Biomed Nanotechnol. 2021;17(7):1435-1447. [54] CHOUIRFA H, BOULOUSSA H, MIGONNEY V, et al. 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1.1 资料来源
1.1.1 检索人及检索时间 第一作者在2022年3月进行检索。
1.1.2 检索文献时限 检索2001年1月至2022年3月发表的相关文献。
1.1.3 检索数据库 PubMed及Web of Science数据库。
1.1.4 检索词 以“Titanium(Ti),Copper(Cu),Antibacterial,Surface modification,Coating”为英文检索词。
1.1.5 检索文献类型 研究性原著、综述及病例报告。
1.1.6 手工检索情况 通过阅读题目及摘要初步筛选,排除与研究无关的文献。
1.1.7 文献检索策略 以PubMed数据库检索为例,见图1。
1.1.8 文献检索量 初检得到相关文献412篇。
1.2 入选标准
纳入标准:①与医用钛合金加入铜的抗菌性能研究密切相关的文章;②与测试加铜后的钛合金细胞毒性及生物力学性能有关的文章;③同一领域的相关性研究选择近年发表的文章。
排除标准:重复性研究;相关性差及无关研究。
1.3 资料提取 根据检索词检索到相关文献后,删除重复性文献进行初筛,初筛得到264篇文献,阅读文献题目及摘要,按照纳入排除标准筛选后最终共纳入76篇文献进行分析和整理。文献检索流程图,见图2。
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文题释义:
医用钛合金:用于制造植入人体内的医疗器件、假体、辅助治疗设备的钛合金,生物力学性能接近人骨,还具备耐疲劳、耐腐蚀及良好的生物相容性等优势。钛及其合金材料因具有良好的生物相容性及优异的力学性能被广泛应用于包括骨科在内的多个医学领域。钛所具备的生物惰性使其在少量氧气存在情况下产生氧化膜,可以使其在体内出现疲劳、抗压甚至出现裂缝的情况下仍然不会与复杂的人体环境发生反应;而且钛不易被磁化,不会妨碍做核磁共振等影像学检查。所以以纯钛、Ti6Al4V合金为代表的钛基合金作为内固定板、螺钉等器械在目前骨科手术中具有不可替代的作用。
作为内植物研究热点之一,广泛的应用所带来的相关感染问题成为不可忽视的一部分,而且治疗感染有目共睹的代价及难度更加凸显了合金本身具备抗菌性能的重要性。而铜作为人体必须的微量元素、钛β相的稳定元素以及抗菌机制清楚的金属元素十分贴合这一需求。采取不同的制备方法将优异且机制清楚的抗菌金属铜加入其中,在不影响生物力学性能的同时可使其具备一定的抗菌能力。该文主要阐述加入金属铜的钛合金材料抗菌性能的最新研究进展,并对其未来进行展望。
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