中国组织工程研究

中国组织工程研究 ›› 2023, Vol. 27 ›› Issue (21): 3368-3374.doi: 10.12307/2023.110

• 生物材料综述 biomaterial review • 上一篇    下一篇

无机非金属生物材料在骨肉瘤治疗与伴发骨缺损再生中的应用

牛  林1，2，3，梅钰坤1，2，邹  蕊1，2，张雨薇1，2，张翼飞1，2，郝雅琪1，2，3，董少杰1，2，3   

  1. 1西安交通大学口腔医院，陕西省颅颌面精准医学研究重点实验室，陕西省西安市  710004；2陕西省牙颌疾病临床研究中心，陕西省西安市 710004；3西安交通大学口腔医院口腔修复科，陕西省西安市  710004
  • 收稿日期:2022-04-13 接受日期:2022-05-11 出版日期:2023-07-28 发布日期:2022-11-24
  • 通讯作者: 董少杰，博士，助理研究员，西安交通大学口腔医院，陕西省颅颌面精准医学研究重点实验室，陕西省西安市 710004；陕西省牙颌疾病临床研究中心，陕西省西安市 710004；西安交通大学口腔医院口腔修复科，陕西省西安市 710004
  • 作者简介:牛林，男，1978年生，陕西省韩城市人，汉族， 2007年四川大学华西口腔医学院毕业，博士，主任医师，研究方向为颌面部生物活性材料。 梅钰坤，男，1996年生，山西省临汾市人，汉族，西安交通大学在读硕士，研究方向为生物活性材料在口腔颅颌面的应用。
  • 基金资助:
    国家自然科学基金青年项目(82102221)，项目负责人：董少杰；西安交通大学基本科研业务费自由探索与创新-教师类项目(xzy012021069)，项目负责人：董少杰；西安市创新能力强基计划-医学研究项目(21YXYJ0123)，项目负责人：董少杰

Application of inorganic nonmetal biomaterials in the treatment of osteosarcoma and the regeneration of tumor-related bone defects

Niu Lin1, 2, 3, Mei Yukun1, 2, Zou Rui1, 2, Zhang Yuwei1, 2, Zhang Yifei1, 2, Hao Yaqi1, 2, 3, Dong Shaojie1, 2, 3   

  1. 1Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, Hospital of Stomatology, Xi’an Jiaotong University, Xi’an 710004, Shaanxi Province, China; 2Clinical Research Center of Shaanxi Province for Dental and Maxillofacial Diseases, Xi’an 710004, Shaanxi Province, China; 3Department of Prosthodontics, Hospital of Stomatology, Xi’an Jiaotong University, Xi’an 710004, Shaanxi Province, China
  • Received:2022-04-13 Accepted:2022-05-11 Online:2023-07-28 Published:2022-11-24
  • Contact: Dong Shaojie, MD, Assistant researcher, Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, Hospital of Stomatology, Xi’an Jiaotong University, Xi’an 710004, Shaanxi Province, China; Clinical Research Center of Shaanxi Province for Dental and Maxillofacial Diseases, Xi’an 710004, Shaanxi Province, China; Department of Prosthodontics, Hospital of Stomatology, Xi’an Jiaotong University, Xi’an 710004, Shaanxi Province, China
  • About author:Niu Lin, MD, Chief physician, Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, Hospital of Stomatology, Xi’an Jiaotong University, Xi’an 710004, Shaanxi Province, China; Clinical Research Center of Shaanxi Province for Dental and Maxillofacial Diseases, Xi’an 710004, Shaanxi Province, China; Department of Prosthodontics, Hospital of Stomatology, Xi’an Jiaotong University, Xi’an 710004, Shaanxi Province, China Mei Yukun, Master candidate, Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, Hospital of Stomatology, Xi’an Jiaotong University, Xi’an 710004, Shaanxi Province, China; Clinical Research Center of Shaanxi Province for Dental and Maxillofacial Diseases, Xi’an 710004, Shaanxi Province, China
  • Supported by:
    National Natural Science Foundation of China (Youth Project), No. 82102221 (to DSJ); Basic Research Funds Free Exploration and Innovation-Teacher Project of Xi’an Jiaotong University, No. xzy012021069 (to DSJ); Xi’an Innovation Capability Strong Foundation Program - Medical Research Project, No. 21YXYJ0123 (to DSJ)

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摘要：


文题释义：

无机非金属生物材料：包括生物玻璃、生物陶瓷、生物水泥及生物玻璃陶瓷等，近年来多用于药物递送载体或植入材料，在骨肉瘤治疗、预防复发、缺损修复方面显示了良好的效果和巨大的潜力。
新兴肿瘤治疗方法：骨肉瘤传统的治疗方法为手术治疗加术后放化疗，其预后欠佳，且患者生存质量较差。目前新兴的研究方法主要包括化学动力学疗法、免疫疗法和光热疗法等，可为临床治疗骨肉瘤提供新思路。

背景：骨肉瘤是临床常见的疾病，近年来将无机非金属生物材料应用于骨肉瘤的治疗成为克服传统治疗瓶颈的新思路。
目的：阐述目前无机非金属生物材料在骨肉瘤诊治中的应用，对其目前的研究现状及未来的应用前景进行综述。
方法：应用计算机检索Web of Science、PubMed和中国知网数据库中涉及无机非金属生物材料用于骨肉瘤诊治相关的研究，主要检索用于骨肉瘤治疗的无机非金属生物材料的制备、应用、动物细胞实验等的实验文献，最终纳入69篇文献进行综述分析。
结果与结论：①无机非金属生物材料具有生物相容性好、理化性质稳定、可生物降解并兼具促成骨功能等优良特征。②无机非金属材料固有的抗断裂性能弱、制备工艺要求高、药物与生物活性分子负载剂量小等不足，限制了其在承力区骨缺损、需持续可控缓释药物等情形的应用。③目前无机非金属材料在骨肉瘤治疗中被广泛应用于纳米载药平台、生物植入支架以及材料表面涂层等方面，并通过功能化改性在骨肉瘤的化学动力学治疗、纳米靶向诊治、催化治疗、免疫治疗和肿瘤热疗等新型诊疗策略中显示出良好效果，但这些研究大多停留在基础实验阶段，尚缺乏临床试验数据的支持。④改进无机非金属材料制备流程、探索新型功能改性策略并进一步广泛开展临床评价，已成为将现有基础研究转化为临床实践并促进无机非金属材料持续发展的关键。
https://orcid.org/0000-0001-5093-0255(牛林)；https://orcid.org/0000-0003-4780-7605(梅钰坤)；https://orcid.org/0000-0001-6021-3620(董少杰)

关键词: 骨肉瘤, 无机非金属材料, 纳米材料, 肿瘤治疗, 生物相容性, 改性, 骨缺损, 成骨

Abstract: BACKGROUND: Osteosarcoma is a common clinical disease. In recent years, the application of inorganic nonmetal biomaterials in the treatment of osteosarcoma has become a new way to overcome the bottleneck of traditional treatment.
OBJECTIVE: To introduce the application of inorganic nonmetal biomaterials in the diagnosis and treatment of osteosarcoma, and to summarize its current research status and future application prospects.
METHODS: A computer-based online search of Web of Science, PubMed, and CNKI was performed to retrieve articles regarding inorganic nonmetal biomaterials in the diagnosis and treatment of osteosarcoma and mainly retrieve experimental articles on the preparation, application and animal cell experiments of inorganic non-metallic biomaterials for osteosarcoma. Finally, 69 articles were included for review. 
RESULTS AND CONCLUSION: (1) Inorganic nonmetal biomaterials have excellent characteristics of good biocompatibility, stable physical and chemical properties, biodegradability and promoting osteogenesis. (2) The inherent shortcomings of inorganic nonmetallic materials, such as weak anti-fracture performance, high preparation process requirements, low loading dose of drugs and bioactive molecules, limit the application in the cases of bone defects in load-bearing areas and controlling drugs releasing. (3) At present, inorganic nonmetal biomaterials such as nano drug loading platform, biological implantation scaffold and material surface coating are wildly used in the treatment of osteosarcoma, which realizing new diagnosis and treatment strategies in chemokinetic therapy, nano targeted diagnosis and treatment, catalytic therapy, immunotherapy and tumor hyperthermia through functional modification. However, these researches mostly stay in the basic experimental stage for lacking of the clinical trial data support. (4) Improving the preparation process of inorganic nonmetallic materials, exploring new functional modification strategies and further extensive clinical evaluation are the key to turn the basic research into clinical practice and promote the sustainable development of inorganic nonmetallic materials.

Key words: osteosarcoma, inorganic nonmetal biomaterial, nano materials, oncotherapy, biocompatibility, modification, bone defect, osteogenesis

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