中国组织工程研究

中国组织工程研究 ›› 2022, Vol. 26 ›› Issue (22): 3580-3585.doi: 10.12307/2022.288

• 生物材料综述 biomaterial review • 上一篇    下一篇

聚己内酯改良生物屏障膜在骨组织工程中的应用

卢海平1，郎雪梅2，张  程1，剧松立1，张  怡3，王  信1   

  1. 1遵义医科大学附属医院骨科，贵州省遵义市   563003；2重庆市急救中心院前急救部，重庆市   400010； 3遵义医科大学公共卫生学院，贵州省遵义市   563000
  • 收稿日期:2021-02-25 修回日期:2021-03-19 接受日期:2021-06-11 出版日期:2022-08-08 发布日期:2022-01-12
  • 通讯作者: 张怡，博士，副教授，硕士生导师，遵义医科大学公共卫生学院，贵州省遵义市 563000 王信，博士，主任医师，博士生导师，遵义医科大学附属医院骨科，贵州省遵义市 563003
  • 作者简介:卢海平，男，1994 年生，贵州省仁怀市人，汉族，遵义医科大学在读硕士，主要从事骨缺损早期愈合的基础研究。 郎雪梅，1983年生，重庆市人，汉族，主治医师，主要从事骨创伤修复研究。
  • 基金资助:
    国家自然科学基金 (31960209，31760266)，项目负责人：王信；贵州省科技厅基础研究计划(黔科合基础[2020]1Y093)，项目负责人：王信；国家自然科学基金 (82060620)，项目负责人：张怡

Application of polycaprolactone modified biological barrier membrane in bone tissue engineering

Lu Haiping1, Lang Xuemei2, Zhang Cheng1, Ju Songli1, Zhang Yi3, Wang Xin1   

  1. 1Department of Orthopedics, Affiliated Hospital of Zunyi Medical University, Zunyi 563003, Guizhou Province, China; 2Pre-hospital Emergency Department of Chongqing Emergency Center, Chongqing 400010, China; 3School of Public Health, Zunyi Medical University, Zunyi 563000, Guizhou Province, China
  • Received:2021-02-25 Revised:2021-03-19 Accepted:2021-06-11 Online:2022-08-08 Published:2022-01-12
  • Contact: Zhang Yi, PhD, Associate professor, Master’s supervisor, School of Public Health, Zunyi Medical University, Zunyi 563000, Guizhou Province, China Wang Xin, PhD, Chief physician, Doctoral supervisor, Department of Orthopedics, Affiliated Hospital of Zunyi Medical University, Zunyi 563003, Guizhou Province, China
  • About author:Lu Haiping, Master candidate, Department of Orthopedics, Affiliated Hospital of Zunyi Medical University, Zunyi 563003, Guizhou Province, China Lang Xuemei, Attending physician, Pre-hospital Emergency Department of Chongqing Emergency Center, Chongqing 400010, China Lu Haiping and Lang Xuemei contributed equally to this article.
  • Supported by:
    National Natural Science Foundation of China, No. 31960209, 31760266 (to WX), No. 82060620 (to ZY); Basic Research Plan of Guizhou Provincial Department of Science and Technology, No. [2020] 1Y093 (to WX)

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摘要：

文题释义：
聚己内酯：一种在组织工程广泛应用，具有生物可吸收性、良好降解性及生物相容性的高分子化合物，已被美国食品和药物管理局(FDA)批准用于临床骨修复和软骨修复。
屏障膜：用来防止周围生长速度较快的纤维组织和上皮组织进入骨缺损内部干扰正常骨再生过程的生物膜。

背景：聚己内酯生物屏障膜的使用可以防止周围生长速度较快的纤维组织和上皮组织进入骨缺损内部，从而避免干扰正常骨再生过程。此外，对聚己内酯生物屏障膜的成骨性能修饰也得到了研究者们的探索。
目的：总结聚己内酯生物屏障膜成骨改良策略，并展望新的聚己内酯生物屏障膜成骨策略。
方法：中文以“聚己内酯屏障膜，成骨，骨替代材料，天然高分子，人工高分子，金属离子，生长因子，干细胞”为关键词，检索中国知网、万方、维普数据库；英文以“Polycaprolactone membrane，osteogenesis，bone substitute material，natural polymer，artificial polymer，metal ion，growth factor，stem cell”为关键词，检索PubMed数据库，选择2000年1月至2021年2月时间段与聚己内酯生物屏障膜相关的文献报道。
结果与结论：聚己内酯材料本身是疏水性的，与其他材料结合首先就得解决这个问题，目前已开发了很多方法，如使用多巴胺、肝素、胶原等作为连接桥梁使聚己内酯材料与其他材料更加相容，但由于不同材料与聚己内酯复合需要条件不一样，新的疏水性改性方法仍需开发。此外，聚己内酯材料及其改性得到了大量研究，聚己内酯与骨替代材料、天然高分子、人工高分子等材料复合已取得较为满意的效果，但由于复合材料成骨活性的限制，新兴的成骨活性物质仍待开发。目前，一些已被证明对各类组织均具有良好再生活性的物质如外泌体、细胞外基质等，与聚己内酯复合材料在骨组织工程及其他领域(如周围神经再生、血管再生等)中极具研究潜力，有望开发成为新兴的组织工程再生策略。

https://orcid.org/0000-0003-4349-9967 (卢海平)

中国组织工程研究杂志出版内容重点：生物材料；骨生物材料; 口腔生物材料; 纳米材料; 缓释材料; 材料相容性；组织工程

关键词: 聚己内酯, 屏障膜, 成骨, 骨再生, 骨组织工程, 复合材料, 综述

Abstract: BACKGROUND: The use of polycaprolactone barrier membrane can prevent the surrounding fast-growing fibrous tissue and epithelial tissue from entering the bone defect thus enhancing bone regeneration process. In addition, the osteogenic modification of the polycaprolactone barrier membrane has been explored by researchers.
OBJECTIVE: To summarize the modification strategies of polycaprolactone barrier membrane, and look forward to new osteogenesis strategies.
METHODS: CNKI, Wanfang, VIP, and PubMed databases were searched with key words of “polycaprolactone membrane, osteogenesis, bone substitute material, natural polymer, artificial polymer, metal ion, growth factor, stem cell” in both Chinese and English for articles regarding polycaprolactone barrier membrane published from January 2000 to February 2021.   
RESULTS AND CONCLUSION: The first problem to be solved for polycaprolactone is to reduce the hydrophobicity when combining with other materials. At present, many methods have been developed as connecting bridges to make polycaprolactone more compatible with other materials, such as dopamine, heparin, and collagen. However, the combination of polycaprolactone with different materials requires diverse conditions, and new hydrophobicity modification methods still need to be explored. In addition, polycaprolactone material and its modification strategies have been widely studied. The research of the incorporation of polycaprolactone with bone substitute material, natural polymer and artificial polymer has achieved pleasing results. Nevertheless, due to the limitation of osteogenesis of composite materials, new osteogenic materials still need to be developed. Presently, there are some substances (such as exosomes and extracellular matrix) that have been verified to exhibit superior osteogenic ability for many kinds of tissues, such as peripheral nerve regeneration and vascular regeneration. The incorporation of polycaprolactone with those active substances is expected to develop into new regeneration strategies for tissue engineering. 

Key words: polycaprolactone, barrier membrane, osteogenesis, bone regeneration, bone tissue engineering, composite materials, review

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