中国组织工程研究 ›› 2013, Vol. 17 ›› Issue (12): 2218-2224.doi: 10.3969/j.issn.2095-4344.2013.12.019

• 生物材料学术探讨 biomaterial academic discussion • 上一篇    下一篇

海藻酸纤维的研究发展及生物医学应用

林晓华,黄宗海,俞金龙   

  1. 南方医科大学珠江医院普外科,广东省广州市 510280
  • 收稿日期:2012-09-13 修回日期:2012-10-28 出版日期:2013-03-19 发布日期:2013-03-19
  • 通讯作者: 黄宗海,博士,硕博生导师,主任,教授,南方医科大学珠江医院普通外科,广东省广州市 510280
  • 作者简介:林晓华,女,1983年生,广东省广州市人,汉族,2007年南方医科大学毕业,医师,主要从事普通外科生物敷料方面的研究。 doctorlin2007@126.com

Alginate fiber: Development and biomedical application

Lin Xiao-hua, Huang Zong-hai, Yu Jin-long   

  1. Department of General Surgery, Zhujiang Hospital of Southern Medical University, Guangzhou 510280, Guangdong Province, China
  • Received:2012-09-13 Revised:2012-10-28 Online:2013-03-19 Published:2013-03-19
  • Contact: Huang Zong-hai, Doctor, Master’s and doctoral supervisor, Professor, Department of General Surgery, Zhujiang Hospital of Southern Medical University, Guangzhou 510280, Guangdong Province, China
  • About author:Lin Xiao-hua, Physician, Department of General Surgery, Zhujiang Hospital of Southern Medical University, Guangzhou 510280, Guangdong Province, China doctorlin2007@126.com

摘要:

背景:海藻酸纤维是一种多形式且多功能性物质,目前已被逐步应用于生物医学及临床。
目的:全面评述海藻酸纤维的结构与功能,同时介绍海藻酸与壳聚糖、海藻酸与明胶共混纤维的特性及在医学上研究的应用情况。
方法:由第一作者检索1990至2012年PubMed数据库及万方数据库有关海藻酸纤维制作过程、海藻酸纤维结构及性能、海藻酸纤维在生物医学的应用情况及其相关共混纤维的特性与应用等方面的文献。
结果与结论:海藻酸盐已被广泛应用于农业化工、生物防治、组织工程、缓释药物系统、创伤修复、净化环境等方面。通过共混改性得到的各种新型混合纤维,不但改善了海藻酸纤维应用上的不足,同时也赋予其更多的性能,成为了当今和未来生物材料的研究热点。目前生物医学材料正向着环保、高功能、智能化等方向发展,自然界储存量丰富、成本价格低廉、具有良好生物相容性及降解性的海藻纤维、壳聚糖纤维和明胶纤维及以它们为基质通过共混和/或改性等方法制造出来的功能性纤维潜力巨大,在生物医学及仿生医学领域有待进一步开发。

关键词: 生物材料, 生物材料学术探讨, 海藻酸, 海藻纤维, 壳聚糖, 明胶, 共混纤维, 组织工程, 综述

Abstract:

BACKGROUND: At present, alginate fiber possesses various forms and functions, which is increasingly used in biomedicine and clinical medicine.
OBJECTIVE: To comprehensively review the structure and feature of alginate fiber and to introduce the biomedical application of its blend fiber with chitosan or gelation.
METHODS: PubMed database and Wanfang database were retrieved by the first author for literature about alginate fiber production process, the alginate fiber structure and properties, biomedical application of alginate fiber, and related blended fiber characteristics and applications, published from 1990 to 2012.
RESULTS AND CONCLUSION: Alginate has been widely applied in agriculture and chemical industry, biological control, tissue engineering, drug delivery system, wound repair, and environmental purification. New hybrid fibers obtained through blending modification cannot only improve the shortcomings of alginate fiber applications, but also be endued with more performances, as biomaterials which have become a research hotspot nowadays and in the future. At present, development of biomedical materials is going towards environmental protection, high functionality, and intellectualized directions. Seaweed fibers, chitosan fibers, gelatin fibers and their blend fibers, which are present with a rich storage in natural, low cost, excellent biocompatibility and degradation, have great potential and have been expected to have further development in biomedicine and bionic medicine.

Key words: biomaterials, biomaterial academic discussion, alginic acid, alginate fiber, chitosan, gelatine, blend fiber, tissue engineering, review

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