中国组织工程研究 ›› 2014, Vol. 18 ›› Issue (8): 1295-1300.doi: 10.3969/j.issn.2095-4344.2014.08.024

• 生物材料临床实践 clinical practice of biomaterials • 上一篇    下一篇

生物与合成敷料封闭负压引流促进植皮创面愈合的对比

流小舟,徐海栋,赵建宁   

  1. 南方医科大学南京临床医学院(解放军南京军区南京总医院)骨科,江苏省南京市  210002
  • 收稿日期:2013-12-04 出版日期:2014-02-19 发布日期:2014-02-19
  • 通讯作者: 徐海栋,博士,主治医师,南方医科大学南京临床医学院(解放军南京军区南京总医院)骨科,江苏省南京市 210002
  • 作者简介:流小舟,男,1984年生,江苏省南京市人,汉族,南方医科大学在读博士,医师,主要从事骨肿瘤及创伤,生物材料研究。

Vacuum-sealing drainages based on biological versus synthetic dressings in wound healing of skin grafting

Liu Xiao-zhou, Xu Hai-dong, Zhao Jian-ning   

  1. Department of Orthopedics, Nanjing Clinical College of Southern Medical University (Nanjing General Hospital of Nanjing Military Region), Nanjing 210002, Jiangsu Province, China
  • Received:2013-12-04 Online:2014-02-19 Published:2014-02-19
  • Contact: Xu Hai-dong, M.D., Attending physician, Department of Orthopedics, Nanjing Clinical College of Southern Medical University (Nanjing General Hospital of Nanjing Military Region), Nanjing 210002, Jiangsu Province, China
  • About author:Liu Xiao-zhou, Studying for doctorate, Physician, Department of Orthopedics, Nanjing Clinical College of Southern Medical University (Nanjing General Hospital of Nanjing Military Region), Nanjing 210002, Jiangsu Province, China

摘要:

背景:骨科创面植皮时采用封闭负压引流可以封闭创面,减少渗出,促进软组织肉芽增生及植皮修复缺损。
目的:对比两种不同材料的创面敷料封闭负压引流在创面植皮中的临床效果。
方法:选择2010年9月至2012年3月收治的80例因创伤需植皮患者,在植皮后按自愿原则进入生物材料(基于丝瓜的植物纤维为敷料主体)及合成材料(聚乙烯乙醇化海藻盐泡沫)创面敷料封闭负压引流治疗。治疗1周后拆除封闭负压引流装置及创面敷料,记录两组的植皮覆盖率及创面愈合时间。
结果与结论:两组患者均有效达到创面植皮覆盖效果,无感染及不愈合情况出现。采用生物材料创面敷料治疗组植皮覆盖率及创面愈合时间均明显优于采用合成材料创面敷料治疗组(P < 0.05)。提示采用生物材料创面敷料封闭负压引流可以有效促进引流,改善循环,抑制细菌增生及促进修复过程。


中国组织工程研究杂志出版内容重点:生物材料;骨生物材料; 口腔生物材料; 纳米材料; 缓释材料; 材料相容性;组织工程


全文链接:

关键词: 生物材料, 材料相容性, 创面敷料, 合成材料, 封闭负压引流, 植皮术, 植皮覆盖率

Abstract:

BACKGROUND: Vacuum-sealing drainage in wound skin grafting can close wound, reduce the leakage, promote granulation hyperplasia and improve skin new speed.
OBJECTIVE: To compare the clinical effects of two kinds of wound surface dressings used in wound skin grafting.
METHODS: Eighty patients who needed skin grafting for trauma were retrospectively studied and chosen from September 2010 to March 2012. They were divided into two groups: biomaterial group (dressings mainly made of luffa fibers) and synthetics group (seaweed polyvinyl alcohol foam). The vacuum-sealing drainage device and wound dressing were removed after 1 week treatment. The skin grafting coverage and wound healing time were recorded.
RESULTS AND CONCLUSION: All patients of two groups got effective skin grafting coverage rate, and no patient appeared with infection and nonunion. The skin grafting coverage and wound healing time of the biomaterial group significantly differed from the synthetics group (P < 0.05). These findings indicate that compared to the synthetic material group, the biomaterial group can be better for effective drainage, good circulation, bacteria inhibition and fast repair.


中国组织工程研究杂志出版内容重点:生物材料;骨生物材料; 口腔生物材料; 纳米材料; 缓释材料; 材料相容性;组织工程


全文链接:

Key words: biocompatible materials, biological dressings, skin transplantation, negative-pressure wound therapy

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