中国组织工程研究

中国组织工程研究 ›› 2011, Vol. 15 ›› Issue (43): 8031-8033.doi: 10.3969/j.issn.1673-8225.2011.43.013

• 人工假体 artificial prosthesis • 上一篇    下一篇

关节置换后血清白细胞介素 6，8，10及C-反应蛋白表达与深静脉血栓形成

杨  峰，随福革，张  勇，李  恒，马东升，李  强，田飞鹏   

  1. 大庆龙南医院骨科四病区，黑龙江省大庆市163453
  • 收稿日期:2011-07-05 修回日期:2011-08-16 出版日期:2011-10-22 发布日期:2011-10-22
  • 作者简介:杨峰★，男，1971年生，黑龙江省大庆市人，汉族，2009年大连医科大学毕业，硕士，主治医师，主要从事骨科学研究。 yangfeng1271030@163.com

Expression of serum interleukin-6, 8, 10, C-reactive protein and deep vein thrombosis after joint replacement

Yang Feng, Sui Fu-ge, Zhang Yong, Li Heng, Ma Dong-sheng, Li Qiang, Tian Fei-peng   

  1. Fourth Ward, Department of Orthopedics, Longnan Hospital of Daqing, Daqing  163453, Heilongjiang Province, China
  • Received:2011-07-05 Revised:2011-08-16 Online:2011-10-22 Published:2011-10-22
  • About author:Yang Feng★, Master, Attending physician, Fourth Ward, Department of Orthopedics, Longnan Hospital of Daqing, Daqing 163453, Heilongjiang Province, China yangfeng1271030@163.com

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摘要：

背景：血管内皮细胞损伤、血流缓慢、血液高凝状态、白细胞流变特性异常是关节置换后深静脉血栓形成的重要因素。
目的：分析关节置换后血清白细胞介素 6，8，10、C-反应蛋白表达特点及与深静脉血栓形成的关系。
方法：检测68例关节置换患者置换前后血清白细胞介素6，8，10及C-反应蛋白浓度，并以超声检测确定是否有下肢深静脉血栓形成。
结果与结论：血栓形成组关节置换后1，3 d白细胞介素6，8，10、C-反应蛋白质量浓度明显高于无血栓组(P < 0.05)，说明炎症因子参与了血栓形成，及时监测上述指标变化有助于预防血栓形成；血栓形成组置换后1，3 d白细胞介素6，8，10、C-反应蛋白质量浓度明显高于置换前1 d(P < 0.05)，置换后5 d上述指标基本接近置换前水平(P > 0.05)。说明关节置换后血液由高凝状态逐渐降低的过程，尤其是置换后3 d是抗炎抗凝治疗的关键。

关键词: 关节置换, 关节成形, 血清白细胞介素, C-反应蛋白, 深静脉血栓

Abstract:

BACKGROUND: Vascular endothelial cell injury, slow blood flow, hypercoagulability, and abnormal white blood cell rheology are the important factors for deep vein thrombosis after joint replacement.
OBJECTIVE: To analyze the association of serum interleukin 6, 8, 10, C-reactive protein expression with deep vein thrombosis after joint replacement.
METHODS: Serum interleukin 6, 8, 10, C-reactive protein expression were detected 68 cases of joint replacement patients before and after replacement, and ultrasonic testing was used to determine whether deep vein thrombosis occurred.
RESULTS AND CONCLUSION: The expression of serum interleukin 6, 8, 10, C-reactive protein in thrombosis patients after joint replacement was higher than that of patients without thrombosis after joint replacement at 1 and 3 days (P < 0.05), indicating inflammatory factors participated in thrombosis formation. Real-time monitoring of changes in these indicators could help to prevent thrombosis. In the patients with thrombosis, the levels of serum interleukin 6, 8, 10, C-reactive protein were higher at 1 and 3 days after joint replacement than before joint replacement (P < 0.05); however, at 5 days after joint replacement, the levels of these indicators were close to those before joint replacement (P> 0.05). After joint replacement, the blood hypercoagulability had a gradual reduction process, especially at 3 days after joint replacement that was a key to anti-inflammatory anticoagulant treatment.

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