中国组织工程研究

中国组织工程研究 ›› 2010, Vol. 14 ›› Issue (41): 7731-7734.doi: 10.3969/j.issn.1673-8225.2010.41.032

• 组织构建学术探讨 tissue construction academic discussion • 上一篇    下一篇

成骨蛋白1在椎间盘退变和修复中的作用

刘航涛1，王万明2，林智军1   

  1. 1解放军南京军区福州总医院附属第一医院骨科，福建省莆田市 351100；  2 解放军南京军区福州总医院骨科，福建省福州市 350025
  • 出版日期:2010-10-08 发布日期:2010-10-08
  • 通讯作者: 王万明，主任医师，博士，硕士生导师，解放军南京军区福州总医院骨科，福建省福州市 350025 wangwm93@126.com
  • 作者简介:刘航涛★，男，1982年生，河南省扶沟县人，汉族，2008年福建中医学院毕业，硕士，医师，主要从事创伤及脊柱临床工作。 liuhangtao_2000@163.com

Role of osteogenic protein-1 in disc degeneration and repair

Liu Hang-tao1, Wang Wan-ming2, Lin Zhi-jun1   

  1. 1 Department of Orthopaedics, First Hospital of Fuzhou General Hospital of Nanjing Military Area Command of Chinese PLA, Putian  351100, Fujian Province, China; 2 Department of Orthopaedics , Fuzhou General Hospital of Nanjing Military Area Command of Chinese PLA, Fuzhou  350025, Fujian Province, China
  • Online:2010-10-08 Published:2010-10-08
  • Contact: Wang Wan-ming, Doctor, Chief physician, Master’s supervisor, Department of Orthopaedics , Fuzhou General Hospital of Nanjing Military Area Command of Chinese PLA, Fuzhou 350025, Fujian Province, China wangwm93@126.com
  • About author:Liu Hang-tao★, Master, Physician, Department of Orthopaedics, First Hospital of Fuzhou General Hospital of Nanjing Military Area Command of Chinese PLA, Putian 351100, Fujian Province, China liuhangtao_2000@163.com

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摘要：

背景：椎间盘的再生修复是当前骨科疾病治疗所面临的一个难题，而成骨蛋白1具有强大的骨诱导活性，能够在体内诱导骨和软骨形成。
目的：总结并讨论成骨蛋白1在椎间盘退变和修复中的作用。
方法：由第一作者用计算机检索中国期刊全文数据库(CNKI：1990/2010)和Pubmed数据库(1990/2010)，检索词分别为“椎间盘，退变，成骨蛋白1/骨形态发生蛋白7”和“intervertebral disc，degeneration，osteogenic protein-1/bone morphogenic protein-7”语言分别设定为中文和英文。从体外和体内两方面对成骨蛋白1对椎间盘细胞及其退变的影响进行介绍。
结果与结论：共检索到56篇文章，按纳入和排除标准对文献进行筛选，共纳入27篇文章。结果表明成骨蛋白1具有促进细胞合成蛋白多糖和胶原的作用，可调节和恢复椎间盘退变中细胞外的基质代谢，可有效延缓椎间盘退变。

关键词: 成骨蛋白1, 椎间盘, 退变, 骨形态发生蛋白7, 髓核, 骨组织构建

Abstract:

BACKGROUND: How to regeneration and repair intervertebral discs puzzles doctors in orthopedics. With a strong osteoinductive activity, osteogenic protein-1 can induce bone and cartilage formation in vivo.
OBJECTIVE: To summarize and discuss the effects of osteogenic protein-1 on disc degeneration and repair.
METHODS: Databases of China Journal of Full-text Database (CNKI) and PubMed were searched by the first author using key words of “intervertebral disc; degeneration; osteogenic protein-1/bone morphogenic protein-7” to find papers published between 1990 and 2010 both in Chinese or English. The effects of osteogenic protein-1 on intervertebral disc cells and its degeneration both in vitro and in vitro were introduced.
RESULTS AND CONCLUSION: Totally 56 papers were retrieved by computer, and 27 documents were selected according to the inclusive and exclusive criteria. As a result, osteogenic protein-1 has an effect on promoting disc cells synthesizing collagen and proteoglycan, can adjust and restorate the metabolism of extracellular matrix in disc degeneration, and shows a bright future to retard disc degeneration.

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