中国组织工程研究

中国组织工程研究 ›› 2024, Vol. 28 ›› Issue (26): 4145-4150.doi: 10.12307/2024.430

• 组织工程相关大数据分析 Big data analysis in tissue engineering • 上一篇    下一篇

细胞凋亡在缺血性脑卒中过程中作用的可视化分析

段彦哲1，滑键林1，2，丁智斌1，3，江  楠4，宋丽娟1，4，闫玉清1，5，马存根1，5   

  1. 1山西中医药大学国家中医药管理局多发性硬化益气活血重点研究室/神经生物学研究中心，山西省晋中市  030619；2国药同煤集团总医院神经外科，山西省大同市  037003；3山西白求恩医院(山西医学科学院同济山西医院)，山西医科大学第三医院，山西省太原市  030032；4山西医科大学细胞生理学省部共建教育部重点实验室，山西省太原市  030001；5山西大同大学脑科学研究所/附属第一医院神经科，山西省大同市  037009
  • 收稿日期:2023-06-05 接受日期:2023-07-22 出版日期:2024-09-18 发布日期:2023-09-28
  • 通讯作者: 闫玉清，博士，教授，硕士生导师，山西中医药大学国家中医药管理局多发性硬化益气活血重点研究室/神经生物学研究中心，山西省晋中市 030619；山西大同大学脑科学研究所/附属第一医院神经科，山西省大同市 037009 宋丽娟，博士，副教授，硕士生导师，山西中医药大学国家中医药管理局多发性硬化益气活血重点研究室/神经生物学研究中心，山西省晋中市 030619；山西医科大学细胞生理学省部共建教育部重点实验室，山西省太原市 030001 马存根，博士，教授，博士生导师，山西中医药大学国家中医药管理局多发性硬化益气活血重点研究室/神经生物学研究中心，山西省晋中市 030619；山西大同大学脑科学研究所/附属第一医院神经科，山西省大同市 037009
  • 作者简介:段彦哲，男，1998年生，山西省洪洞县人，汉族，山西中医药大学在读硕士，主要从事中西医结合防治脑血管疾病的作用及其机制研究。
  • 基金资助:
    国家自然科学基金项目(82004028)，项目负责人：宋丽娟；国家自然科学基金项目(81473577)，项目负责人：马存根；中国博士后科学基金面上资助项目(2020M680912)，项目负责人：宋丽娟；国家中医药管理局“张仲景传承与创新专项”(GZY-KJS-2022-048-1)，项目负责人：宋丽娟；山西省科技创新人才青年团队项目(202204051001028)，项目负责人：宋丽娟；山西中医药大学2022年度科技创新团队项目(2022TD2010)，项目负责人：宋丽娟、马存根；山西省卫健委医学科技领军团队项目(2020TD05)，项目负责人：马存根；山西中医药大学附属医院国家区域中医医疗中心心血管专项基金项目(XGZX202115)，项目负责人：宋丽娟；山西中医药大学青年科学家培育项目(2021PY-QN-09)，项目负责人：宋丽娟；山西中医药大学学科建设经费(2023XKJS-02)，项目负责人：马存根

Visual analysis of the effect of apoptosis on ischemic stroke

Duan Yanzhe1, Hua Jianlin1, 2, Ding Zhibin1, 3, Jiang Nan4, Song Lijuan1, 4, Yan Yuqing1, 5, Ma Cungen1, 5   

  1. 1Key Laboratory of Invigorating Qi and Activating Blood Circulation of Multiple Sclerosis/Neurobiology Research Center, State Administration of Traditional Chinese Medicine, Shanxi University of Chinese Medicine, Jinzhong 030619, Shanxi Province, China; 2Department of Neurosurgery, Sinopharm Coal Group General Hospital, Datong 037003, Shanxi Province, China; 3Shanxi Bethune Hospital (Tongji Shanxi Hospital, Shanxi Academy of Medical Sciences), The Third Hospital of Shanxi Medical University, Taiyuan 030032, Shanxi Province, China; 4Key Laboratory of Cell Physiology, Ministry of Education, Shanxi Medical University, Taiyuan 030001, Shanxi Province, China; 5Department of Neurology, Institute of Brain Science, The First Affiliated Hospital of Shanxi Datong University, Datong 037009, Shanxi Province, China
  • Received:2023-06-05 Accepted:2023-07-22 Online:2024-09-18 Published:2023-09-28
  • Contact: Yan Yuqing, MD, Professor, Master’s supervisor, Key Laboratory of Invigorating Qi and Activating Blood Circulation of Multiple Sclerosis/Neurobiology Research Center, State Administration of Traditional Chinese Medicine, Shanxi University of Chinese Medicine, Jinzhong 030619, Shanxi Province, China; Department of Neurology, Institute of Brain Science, The First Affiliated Hospital of Shanxi Datong University, Datong 037009, Shanxi Province, China Song Lijuan, MD, Associate professor, Master’s supervisor, Key Laboratory of Invigorating Qi and Activating Blood Circulation of Multiple Sclerosis/Neurobiology Research Center, State Administration of Traditional Chinese Medicine, Shanxi University of Chinese Medicine, Jinzhong 030619, Shanxi Province, China; Key Laboratory of Cell Physiology, Ministry of Education, Shanxi Medical University, Taiyuan 030001, Shanxi Province, China Ma Cungen, MD, Professor, Doctoral supervisor, Key Laboratory of Invigorating Qi and Activating Blood Circulation of Multiple Sclerosis/Neurobiology Research Center, State Administration of Traditional Chinese Medicine, Shanxi University of Chinese Medicine, Jinzhong 030619, Shanxi Province, China; Department of Neurology, Institute of Brain Science, The First Affiliated Hospital of Shanxi Datong University, Datong 037009, Shanxi Province, China
  • About author:Duan Yanzhe, Master candidate, Key Laboratory of Invigorating Qi and Activating Blood Circulation of Multiple Sclerosis/Neurobiology Research Center, State Administration of Traditional Chinese Medicine, Shanxi University of Chinese Medicine, Jinzhong 030619, Shanxi Province, China
  • Supported by:
    National Natural Science Foundation of China, Nos. 82004028 (to SLJ) and 81473577 (to MCG); China Postdoctoral Science Foundation, No. 2020M680912 (to SLJ); “Zhang Zhongjing Inheritance and Innovation Special Project” of the State Administration of Traditional Chinese Medicine, No. GZY-KJS-2022-048-1 (to SLJ); Shanxi Provincial Science and Technology Innovation Talent Young Team Project, No. 202204051001028 (to SLJ); 2022 Annual Science and Technology Innovation Team Project of Shanxi University of Chinese Medicine, No. 2022TD2010 (to SLJ and MCG); Medical Science and Technology Leadership Team Project of Shanxi Provincial Healthcare Commission, No. 2020TD05 (to MCG); Cardiovascular Special Fund Project of National Regional TCM Medical Center, Affiliated Hospital of Shanxi University of Chinese Medicine, No. XGZX202115 (to SLJ); Young Scientist Training Program of Shanxi University of Chinese Medicine, No. 2021PY-QN-09 (to SLJ); Discipline Construction Fund of Shanxi University of Chinese Medicine, No. 2023XKJS-02 (to MCG)

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摘要：


文题释义：

文献计量学：是以文献体系和文献计量特征为研究对象，采用数学、统计学等计量研究方法，研究文献情报的分布结构、数量关系、变化规律和定量管理，进而探讨科学技术某些结构、特征和规律的一门学科。
细胞凋亡：指为维持内环境稳定，由基因控制的细胞自主的有序的死亡。细胞凋亡与细胞坏死不同，细胞凋亡不是一个被动的过程，而是主动过程，它涉及一系列基因的激活、表达以及调控等的作用。细胞凋亡并不是病理条件下自体损伤的一种现象，而是为更好地适应生存环境而主动争取的一种死亡过程。


背景：缺血性脑卒中是一种与细胞凋亡相关的高发性疾病。在脑缺血后会出现神经元的死亡，包括坏死和凋亡两种方式。缺血核心区以坏死为主，而半暗带内的迟发性神经元死亡则以凋亡为主，半暗带已经成为现在缺血性脑卒中治疗的靶点。此文献计量分析用于确定过去5年缺血性脑卒中中细胞凋亡的全球科学产出特征、热点和前沿。

目的：采用文献计量学的方法分析缺血性脑卒中病理过程中细胞凋亡的作用及其机制。
方法：从Web of Science Core Collection的科学引文索引扩展(SCI-Expanded)和社会科学引文索引扩展(SSCI-Expanded)中检索2018-2022年缺血性脑卒中中细胞凋亡的相关文献记录927篇。使用citespace、VOSviewer和Bibliometrix对缺血性脑卒中中细胞凋亡的研究趋势和热点进行可视化分析。

结果与结论：①在过去5年中，2018-2020年有关细胞凋亡在缺血性脑卒中中的作用发文量呈上升趋势，但在2020年发生转折，发文数量开始下降；其中中国的发文量最多，美国居于第2名；首都医科大学和《BRAIN RESEARCH BULLETIN》分别是发文最多的机构和期刊；近年来，“Expression”和“Oxidative stress”这2个关键词出现的频率较高；②文献计量学研究表明，在过去的5年中，大多数研究主要集中在基础研究上，其中细胞凋亡在缺血性脑卒中中的作用在近3年的研究中逐渐减少，呈现下降趋势；反之，神经再生逐渐成为了一个研究的热点，尤其在不同机制影响下对神经营养因子的调控，以及在血管生成和胶质细胞修复方面的研究呈上升趋势，同时在神经再生中细胞凋亡是一个潜在的发掘点。

https://orcid.org/0009-0002-8204-6442(段彦哲)

中国组织工程研究杂志出版内容重点：组织构建；骨细胞；软骨细胞；细胞培养；成纤维细胞；血管内皮细胞；骨质疏松；组织工程

关键词: 文献计量学, 细胞凋亡, 缺血性脑卒中, VOSviewer, Citespace

Abstract: BACKGROUND: Ischemic stroke is a highly prevalent disease associated with apoptosis. Neuronal death occurs after cerebral ischemia, including necrosis and apoptosis. The ischemic core region is dominated by necrosis, while delayed neuronal death in the penumbra is dominated by apoptosis. The penumbra has become a target for the treatment of ischemic stroke. This bibliometric analysis was used to identify the characteristics, hotspots, and frontiers of global scientific output related to apoptosis in ischemic stroke over the past 5 years. 
OBJECTIVE: To analyze the role of apoptosis and its mechanisms in the pathological process of ischemic stroke through a bibliometric approach.
METHODS: A total of 927 relevant literature records from 2018 to 2022 were retrieved from Science Citation Index Expanded (SCI-Expanded) and Social Science Citation Index Expanded (SSCI-Expanded) of the Web of Science Core Collection. Research trends and hotspots of apoptosis in ischemic stroke were visualized using Citespace, VOSviewer and Bibliometrix. 
RESULTS AND CONCLUSION: From 2018 to 2020, the number of papers on the role of apoptosis in ischemic stroke showed an upward trend, but in 2020, the number of papers began to reduce. China had the largest number of publications, and the United States ranked the second. Capital Medical University and BRAIN RESEARCH BULLETIN were the institutions and journals with the most articles, respectively. In recent years, the two keywords “expression” and “oxidative stress” have appeared more frequently. The bibliometric study showed that in the past 5 years, most of the studies focused on basic research, in which research on the role of apoptosis in ischemic stroke has gradually decreased in the last 3 years, showing a downward trend. On the contrary, nerve regeneration has gradually become a research hotspot, especially the regulation of neurotrophic factors under the influence of different mechanisms, and the research on angiogenesis and glial cell repair is on the rise. At the same time, apoptosis in nerve regeneration is a potential point of discovery.

Key words: bibliometrics, cell apoptosis, ischemic stroke, VOSviewer, Citespace

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