[1] BOSTRÖM P, WU J, JEDRYCHOWSKI MP, et al. A PGC1α-dependent myokine that drives browning of white fat and thermogenesis. Nature. 2012;481(7382):463-468.
[2] MARIA AS, NAGABABU C, TOMOO O, et al. The Structure of Irisin Reveals a Novel Intersubunit-Sheet Fibronectin Type III (FNIII) Dimer. J Biol Chem. 2013;288(47):33738-33744.
[3] CHEN K, XU Z, LIU Y, et al. Irisin protects mitochondria function during pulmonary ischemia/reperfusion injury. Sci Transl Med. 2017; 9(418):eaao6298.
[4] 王震. 不同药物干预心、肾缺血再灌注损伤的作用与机制研究[D]. 重庆: 第三军医大学,2015.
[5] 吕勃. 整合素αV对内皮祖细胞治疗心肌缺血的影响[D]. 哈尔滨: 哈尔滨医科大学,2010.
[6] KANAZAWA H, IMOTO K, OKADA M, et al. Canstatin inhibits hypoxia-induced apoptosis through activation of integrin/focal adhesion kinase/Akt signaling pathway in H9C2 cardiomyoblasts. Plos One. 2017;12(2):e0173051.
[7] MEOLI DF, SADEGHI MM, KRASSILNIKOVA S, et al. Noninvasive imaging of myocardial angiogenesis following experimental myocardial infarction. J Clin Invest. 2004;113(12):1684-1691.
[8] SARRAZY V, KOEHLER A, CHOW ML, et al. Integrins αvβ5 and αvβ3 promote latent TGF-β1 activation by human cardiac fibroblast contraction. Cardiovasc Res. 2014;102(3):407-417.
[9] GRÖNMAN M, TARKIA M, KIVINIEMI T, et al. Imaging of αvβ3 integrin expression in experimental myocardial ischemia with [68Ga]NODAGA-RGD positron emission tomography. J Transl Med. 2017;15(1):144.
[10] FABIAN SG, CARME PQ. The p38–PGC-1α–irisin–betatrophin axis: Exploring new pathways in insulin resistance. Adipocyte. 2013;3(1):67-68.
[11] XIE C, ZHANG Y, TRAN TDN, et al. Irisin Controls Growth, Intracellular Ca2+ Signals, and Mitochondrial Thermogenesis in Cardiomyoblasts. Plos One. 2015;10(8):e0136816.
[12] KIM H, WRANN CD, JEDRYCHOWSKI M, et al. Irisin Mediates Effects on Bone and Fat via αV Integrin Receptors. Cell. 2018;175(7):1756-1768.
[13] Wang H, Zhao YT, Zhang S, et al. Irisin plays a pivotal role to protect the heart against ischemia and reperfusion injury. J Cell Physiol. 2017; 232(12):3775-3785.
[14] Arsenijevic D, Onuma H, Pecqueur C, et al. Disruption of the uncoupling protein-2 gene in mice reveals a role in immunity and reactive oxygen species production. Nat Genet. 2000;26(4):435-439.
[15] MCLEOD CJ, HOYT RF, SACK MN. UCP2: A functional target in delayed preconditioning induced cardioprotection. Cardiovasc J Afr. 2004;15(4supp1):S4-S6.
[16] MCLEOD CJ, AZIZ A, HOYT RF JR, et al. Uncoupling proteins 2 and 3 function in concert to augment tolerance to cardiac ischemia. J Biol Chem. 2005;280(39):33470-33476.
[17] BOSS O, SAMEC S, DESPLANCHES D, et al. Effect of endurance training on mRNA expression of uncoupling protein 1, 2, and 3 in rat. Faseb J. 1998;12(3):335-339.
[18] CHEN RR, FAN XH, CHEN G, et al. Irisin attenuates angiotensin II-induced cardiac fibrosis via Nrf2 mediated inhibition of ROS/TGFβ1/Smad2/3 signaling axis. Chem Biol Interact. 2019;302:11-21.
[19] 毋江波, 谢安青, 张勇. 有氧运动通过鸢尾素改善慢性心力衰竭的机制[J]. 中国组织工程研究,2019,23(11):1781-1787.
[20] 李楠, 王江, 高峰, 等. 心力衰竭大鼠解偶联蛋白2表达及对线粒体功能的影响[J]. 岭南心血管病杂志,2009,15(6):474-478.
[21] BO H, JIANG N, MA GD, et al. Regulation of mitochondrial uncoupling respiration during exercise in rat heart: Role of reactive oxygen species(ROS)and uncoupling protein 2. Free Radic Biol Med. 2008; 44(7):1373-1381.
[22] HYNES RO. Integrins: Bidirectional, Allosteric Signaling Machines. Cell. 2002;110(6):673-687.
[23] HAYASHI Y, HAIMOVICH B, RESZKA A, et al. Expression and function of chicken integrin beta 1 subunit and its cytoplasmic domain mutants in mouse NIH 3T3 cells. J Cell Biol. 1990;110(1):175-182.
[24] TIAN J, ZHANG FJ, LEI GH. Role of integrins and their ligands in osteoarthritic cartilage. Rheumatol Int. 2015;35(5):787-798.
[25] LUO BH, CARMAN CV, SPRINGER TA. Structural Basis of Integrin Regulation and Signaling. Annu Rev Immunol. 2007;25(1):619-647.
[26] MARA B, EMILIO H, ANTONELLA N, et al. Integrin signalling: the tug-of-war in heart hypertrophy. Cardiovasc Res. 2006;70(3):422-433.
[27] ROSS RS, BORG TK. Integrins and the myocardium. Circ Res. 2001; 88(11):1112-1119.
[28] PFISTER R, ACKSTEINER C, BAUMGARTH J, et al. Loss of beta 1D-integrin function in human ischemic cardiomyopathy. Basic Res Cardiol. 2007; 102(3):257-264.
[29] HANNIGAN GE, COLES JG, DEDHAR S. Intergin-linked kinase at the heart of cardiac contractility, repair and disease. Circ Res. 2007;100(10): 1408-1414.
[30] CASTALDO C, DI MEGLIO F, NURZYNSKA D, et al. CD117-Positive Cells in Adult Human Heart Are Localized in the Subepicardium, and Their Activation Is Associated with Laminin-1 and α6 Integrin Expression. Stem Cells. 2008;26(7):1723-1731.
[31] MAITRA N, FLINK IL,BAHL JJ, et al. Expression of alpha and beta integrins during terminal differentiation of cardiomyocytes. Cardiovasc Res. 2000;47(4):715-725.
[32] KUZMAN J, KACIMI R, GERDES AM. 14 Integrin alterations during LV myocyte remodeling in spontaneously hypertensive heart failure (SHHF) rats. J Mol Cell Cardiol. 2002;34(7):A14.
[33] DULLENS HF, SCHIPPER ME, VAN KUIK J, et al. Integrin expression during reverse remodeling in the myocardium of heart failure patients. Cardiovasc Pathol. 2012;21(4):291-298.
[34] MONDAL NK, CHEN Z, TRIVEDI JR, et al. Oxidative stress induced modulation of platelet integrin αIIbβ3 expression and shedding may predict the risk of major bleeding in heart failure patients supported by continuous flow left ventricular assist devices. Thromb Res. 2017; 158:140-148.
[35] MEOLI DF, SADEGHI MM, KRASSILNIKOVA S, et al. Noninvasive imaging of myocardial angiogenesis following experimental myocardial infarction. J Clin Invest. 2004;113(12):1684-1691.
[36] HIGUCHI T, BENGEL FM, SEIDL S, et al. Assessment of alphavbeta3 integrin expression after myocardial infarction by positron emission tomography. Cardiovasc Res. 2008;78(2):395- 403.
[37] KHURANA R, SIMONS PM, MARTIN JF, et al. Role of Angiogenesis in Cardiovascular Disease: a critical appraisal. Circulation. 2005;112(12): 1813-1824.
[38] JENKINS WSA, STIRRAT C, CONNELL M, et al. Cardiac αVβ3 integrin expression following acute myocardial infarction in humans. Heart. 2017;103(8):607-615.
[39] CHUN TY, BLOEM L, PRATT JH. Spironolactone increases integrin β3 gene expression in kidney and heart muscle cells. Mol Cell Endocrinol. 2002;194(1):175-182.
[40] DELON I, BROWN NH. Integrins and the actin cytoskeleton. Curr Opin Cell Biol. 2007;19(1):43-50.
[41] GEIGER B, BERSHADSKY A, PANKOV R, et al. Transmembrane crosstalk between the extracellular matrix-cytoskeleton crosstalk. Nat Rev Mol Cell Biol. 2001;2(11):793-805.
[42] HANNIGAN GE, FITZGIBBON L, COPPOLINO MG, et al. Regulation of cell adhesion and anchorage-dependent growth by a new beta1-integrin-linked protein kinase. Nature. 1996;379(6560):91-96.
[43] HANNIGAN GE, COLES JG, DEDHAR S. Integrin-linked kinase at the heart of cardiac contractility, repair, and disease. Circ Res. 2007;100(10): 1408-1414.
[44] 郑利民,方明镜.整合素连接激酶(ILK)参与肿瘤的形成和转移的研究进展[J].医学研究杂志,2005,34(12):60-61.
[45] LEGATE KR, MONTAÑEZ E, KUDLACEK O, et al. ILK, PINCH and parvin: the tIPP of integrin signaling. Nat Rev Mol Cell Biol. 2006;7(1):20-31.
[46] NISHIMURA M, KUMSTA C, KAUSHIK G, et al. A dual role for integrin-linked kinase and β1-integrin in modulating cardiac aging. Aging Cell. 2014;13(3):431-440.
[47] DAI J, MATSUI T, ABEL ED, et al. Deep sequence analysis of gene expression identifies osteopontin as a downstream effector of integrin-linked kinase (ILK) in cardiac-specific ILK knockout mice. Circ Heart Fail. 2014;7(1):184-193.
[48] WHITE DE, COUTU P, SHI YF, et al. Targeted ablation of ILK from the murine heart results in dilated cardiomyopathy and spontaneous heart failure.Gene Dev. 2006;20(17):2355-2360.
[49] LU W, LU W, XU B. Increased expression of integrin-linked kinase improves cardiac function after myocardial infarction in the swine. Heart. 2010;96(Suppl 3):A133-A134.
[50] CALDERWOOD DA, CAMPBELL ID, CRITCHLEY DR. Talins and kindlins: Partners in integrin-mediated adhesion. Nat Rev Mol Cell Biol. 2013; 14(8):503-517.
[51] ZHANG X, JIANG G, CAI Y, et al. Talin depletion reveals independence of initial cell spreading from integrin activation and traction. Nat Cell Biol. 2008;10(9):1062-1068.
[52] ELOSEGUI-ARTOLA A, ORIA R, CHEN Y, et al. Mechanical regulation of a molecular clutch defines force transmission and transduction in response to matrix rigidity. Nat Cell Biol. 2016;18(5):540-548.
[53] AUSTEN K, RINGER P, MEHLICH A, et al. Extracellular rigidity sensing by talin isoform-specific mechanical linkages. Nat Cell Biol. 2015;17(12): 1597-1606.
[54] MANSO AM, OKADA H, SAKAMOTO FM, et al. Loss of mouse cardiomyocyte talin-1 and talin-2 leads to β-1 integrin reduction, costameric instability, and dilated cardiomyopathy. Proc Natl Acad Sci USA. 2017;114(30):E6250-E6259.
[55] SHIMAOKA M, TAKAGI J, SPRINGER TA. Conformational Regulation of Integrin Structure and Function. Annu Rev Biophys Biomol Struct. 2002;31(1):485-516.
[56] WANG D, GUO Q, WEI A, et al. Differential Binding of Active and Inactive Integrin to Talin. Protein J. 2018;37(3):280-289.
[57] KIM C, YE F, HU X, et al. Talin activates integrins by altering the topology of the beta transmembrane domain. J Cell Biol. 2012;197(5):605-611.
[58] LI A, GUO Q, KIM C, et al. Integrin alphaII b tail distal of GFFKR participates in inside-out alphaII b beta3 activation. J Thromb Haemost. 2014;12(7):1145-1155.
[59] HAYDARI Z, SHAMS H, JAHED Z, et al. Kindlin Cooperates with Talin for Integrin Activation, a Molecular Dynamics Approach. Biophys J. 2020; 118(3):504a.
[60] HWANG S, LEE HJ, KIM G, et al. CCN1 acutely increases nitric oxide production via integrin alphavbeta3-Akt-S6K-phosphorylation of endothelial nitric oxide synthase at the serine 1177 signaling axis. Free Radic Biol Med. 2015;89:229-240.
[61] RIOPEL M, STUART W, WANG R. Fibrin improves beta (INS-1) cell function, proliferation and survival through integrin alphavbeta3. Acta Biomater. 2013;9(9):8140-8148.
[62] LANE D, GONCHARENKO-KHAIDER N, RANCOURT C, et al. Ovarian cancer ascites protects from TRAILinduced cell death through alphavbeta5 integrin-mediated focal adhesion kinase and Akt activation. Oncogene. 2010;29(24):3519-3531.
[63] FUJIO Y, NGUYEN T, WENCKER D, et al. Akt promotes survival of cardiomyocytes in vitro and protects against ischemia-reperfusion injury in mouse heart. Circulation. 2000;101(6):660-667.
[64] 胡明珠, 周波, 盛琼, 等. PI3K/Akt/Sirt1信号通路介导硫化氢后处理对大鼠缺血心肌的保护作用[J].中国药理学通报,2016,32(2): 268-273.
[65] 胡明珠. PI3K/Akt/Sirt1/PGC-1α信号通路介导H2S后处理对大鼠缺血心肌的保护作用[D]. 无锡:江南大学,2016.
[66] 周爽,李莉,张慧娜,等. SIRT1通过上调MnSOD的表达保护糖尿病导致的内皮细胞损伤[C]. 国际心脏研究会(ISHR)中国分会第十届暨中国病理生理学会心血管专业委员会第十三届学术会议论文摘要文集, 温州:2008.
[67] YAO ZQ, ZHANG X, ZHEN Y, et al. A novel small-molecule activator of Sirtuin-1 induces autophagic cell death/mitophagy as a potential therapeutic strategy in glioblastoma. Cell Death Dis. 2018;9(7):767.
[68] 李晓燕, 韩霞, 张红明, 等. 耐力运动训练通过SIRT1信号通路保护力竭运动大鼠心肌[J]. 中华心血管病杂志,2017,45(6):501-506.
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