中国组织工程研究

中国组织工程研究 ›› 2021, Vol. 25 ›› Issue (10): 1616-1621.doi: 10.3969/j.issn.2095-4344.3064

• 生物材料综述 biomaterial review • 上一篇    下一篇

电加工技术对组织工程研究进展的贡献

吕鹏程1，2，3，张  倩1，2，毛吉富1，2，3，劳继红1，2，王  璐1，2，3   

  1. 东华大学，1纺织学院，2纺织面料技术教育部重点实验室，3纺织行业生物医用纺织材料与技术重点实验室，上海市   201620
  • 收稿日期:2020-04-23 修回日期:2020-04-26 接受日期:2020-06-17 出版日期:2021-04-08 发布日期:2020-12-18
  • 通讯作者: 毛吉富，特聘研究员，博士生导师，东华大学，纺织学院，纺织面料技术教育部重点实验室，纺织行业生物医用纺织材料与技术重点实验室，上海市 201620
  • 作者简介:吕鹏程，男，1996年生，河南省洛阳市人，东华大学在读硕士，主要从事生物医用纺织材料的研究。
  • 基金资助:
    中央高校基本科研业务费专项资金(2232020G-01)，项目负责人：毛吉富；东华大学高层次人才科研启动经费，项目负责人：毛吉富；高等学校学科创新引智计划资助(BP0719035)，项目负责人：王璐

Contribution of electrofabrication technology to the progress of tissue engineering research

Lü Pengcheng1, 2, 3, Zhang Qian1, 2, Mao Jifu1, 2, 3, Lao Jihong1, 2, Wang Lu1, 2, 3    

  1. 1College of Textile, Donghua University, Shanghai 201620, China; 2Key Laboratory of Textile Science & Technology, Ministry of Education, Donghua University, Shanghai 201620, China; 3Key Laboratory of Biomedical Textile Materials and Technology in Textile Industry, Donghua University, Shanghai 201620, China
  • Received:2020-04-23 Revised:2020-04-26 Accepted:2020-06-17 Online:2021-04-08 Published:2020-12-18
  • Contact: Mao Jifu, Researcher, Doctoral supervisor, College of Textile, Donghua University, Shanghai 201620, China; Key Laboratory of Textile Science & Technology, Ministry of Education, Donghua University, Shanghai 201620, China; Key Laboratory of Biomedical Textile Materials and Technology in Textile Industry, Donghua University, Shanghai 201620, China
  • About author:Lü Pengcheng, Master candidate, College of Textile, Donghua University, Shanghai 201620, China; Key Laboratory of Textile Science & Technology, Ministry of Education, Donghua University, Shanghai 201620, China; Key Laboratory of Biomedical Textile Materials and Technology in Textile Industry, Donghua University, Shanghai 201620, China
  • Supported by:
    the Fundamental Research Funds for the Central Universities, No. 2232020G-01 (to MJF); the Research Start-up Funds for High-Level Talents of Donghua University (to MJF); the Subject Innovation and Talent Introduction Program in Colleges and Universities, No. BP0719035 (to WL)

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摘要：

文题释义：
电加工：指使用电信号输入(电压、电流等)直接或间接地在电极表面构建具有一定结构和功能材料的加工方法。通过精确的电信号输入可在任何导电表面上快速可控地形成薄膜或者水凝胶材料，加工条件温和，不引入生物毒性物质，因此在加工过程中允许生物活性分子、纳米微粒、药物或细胞的包封。
组织工程支架：是组织工程3要素之一，其主要作用是为种子细胞提供仿生微环境，从而促进细胞的黏附、增殖和分化。

背景：电加工技术拓宽了生物医用材料的结构、性能及应用，通过优选材料和调控结构可构建出更符合人体生理环境的组织工程支架材料，对推动组织工程和再生医学具有重大意义。
目的：综述电加工技术在组织工程中的研究进展。
方法：以“tissue engineering scaffold，electrodeposition，electrofabrication，electrogelation，bioprinting，biomedical materials，biopolymers”等为英文检索词，检索Web of Science核心合集、MEDLINE等数据库，根据纳入与排除标准对文章进行筛选后保留相关性较高的文章进行综述。
结果与结论：电加工技术可以通过精确的空间、时间和定量控制来施加电信号，调控材料孔隙或分层结构，从而快速可控地构建具有复杂微观结构的功能化组织工程支架，且制备过程不引入有机溶剂或其他生物毒性物质。尽管电加工方法在生物材料制备领域有了众多研究成果，但对于电加工参数如何影响材料结构和沉积动力学等方面的研究较少，仍需要进一步的理论和建模工作来深入理解电加工所涉及的机制。
https://orcid.org/0000-0002-3845-3051 (吕鹏程)

中国组织工程研究杂志出版内容重点：生物材料；骨生物材料; 口腔生物材料; 纳米材料; 缓释材料; 材料相容性；组织工程

关键词: 材料, 组织工程, 支架, 电加工, 电沉积, 电凝胶, 自组装, 结构调控, 综述

Abstract: BACKGROUND: Electrofabrication has broadened the structure, performance, and applications of biomedical materials. Through selecting appropriate materials and optimizing structures, tissue engineering scaffolds that conform to human physiological environment can be constructed, which is of considerable significance to promote the development of tissue engineering and regenerative medicine. 
OBJECTIVE: To review the research progress of electrofabrication technology in tissue engineering.
METHODS: Web of Science Core Collection and MEDLINE databases were searched for relevant articles with the search terms “tissue engineering scaffold, electrodeposition, electrofabrication, electrogelation, bioprinting, biomedical materials, biopolymers” in English. After screening articles based on inclusion and exclusion criteria, articles with higher relevance were retained for review.
RESULTS AND CONCLUSION: Electrofabrication can apply electrical signals to regulate material pores or layered structures through precise spatial, temporal and quantitative control, can quickly and controllably construct functional tissue engineering scaffold materials with complicated microstructures, but without the introduction of organic solvents or other biotoxic substances during the processing. Although there have been many research results on the electrofabrication of biological materials, there are few studies on how the electrofabrication parameters affect the material structure and deposition dynamics, and further theoretical and modeling work is needed to understand the mechanism involved in electrofabrication.


Key words: material, tissue engineering, scaffold, electrofabrication, electrodeposition, electrogelation, self-assembly, structural regulation, review

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