中国组织工程研究 ›› 2019, Vol. 23 ›› Issue (34): 5508-5515.doi: 10.3969/j.issn.2095-4344.1956

• 生物材料综述 biomaterial review • 上一篇    下一篇

智能响应性水凝胶作为药物递送系统的研究与应用

崔宇韬,刘  贺,冀  璇,冷  一,任震晓,李祖浩,吴丹凯
  

  1. 吉林大学第二医院骨科,吉林省长春市  130041
  • 收稿日期:2019-06-21 出版日期:2019-12-08 发布日期:2019-12-08
  • 通讯作者: 吴丹凯,主任医师,教授,硕士生导师,吉林大学第二医院骨科,吉林省长春市 130041
  • 作者简介:崔宇韬,男,1995 年生,汉族,吉林大学第二医院骨科在读硕士,主要从事局部药物递送系统的研究。
  • 基金资助:

    国家自然科学基金(81671804,81772456),项目参与人:刘贺

Research progress of smart responsive hydrogel as a drug delivery system

Cui Yutao, Liu He, Ji Xuan, Leng Yi, Ren Zhenxiao, Li Zuhao, Wu Dankai
  

  1. Department of Orthopedics, Second Hospital of Jilin University, Changchun 130041, Jilin Province, China
  • Received:2019-06-21 Online:2019-12-08 Published:2019-12-08
  • Contact: Wu Dankai, Chief physician, Professor, Master’s supervisor, Department of Orthopedics, Second Hospital of Jilin University, Changchun 130041, Jilin Province, China
  • About author:Cui Yutao, Master candidate, Department of Orthopedics, Second Hospital of Jilin University, Changchun 130041, Jilin Province, China
  • Supported by:

    the National Natural Science Foundation of China, No. 81671804, 81772456 (to LH)

摘要:

文章快速阅读:

 

文题释义:
智能响应性水凝胶:是一种能感知外部环境刺激如温度、pH值、光电及生物酶等的一类新型水凝胶,是现代高技术新材料发展的重要方向之一。
药物递送系统:是指在时间、空间和剂量上能够对药物在生物体内分布进行全面调控的技术体系。其目标是在恰当的时机将适量的药物递送到正确的位置,从而增加药物的生物利用度,提高疗效和降低成本的同时并减少毒副作用。
 
 
背景:水凝胶在药物缓释、靶向递送方面发挥着重要的作用。但由于人体正常微环境和各患病部位之间生理条件的巨大变化,普通的水凝胶作为局部药物缓释系统可能无法在复杂的病理微环境中实现预期目标。因此,对于药物递送非常需要具有环境响应性功能的聚合物材料。
目的:介绍刺激响应水凝胶的最新研究进展,描述其合成策略,并强调其在药物输送中的应用,最后讨论当前的研究重点和未来趋势。
方法:作者以“responsive hydrogel,temperature-responsive hydrogel,pH-responsive hydrogel hydrogel,drug delivery,响应性水凝胶,温敏性水凝胶,pH响应性水凝胶,药物递送”为关键词,检索2007至2019年PubMed、Web of Science、Medline、万方、CNKI数据库中相关文献。
结果与结论:初检文章352篇,筛选后纳入62篇。根据微环境变化如温度升高、pH值降低、过量表达的特异性酶、氧化还原剂的聚集等可设计环境响应性智能水凝胶。环境的改变可使智能水凝胶材料发生氢键减少,电荷排斥力增加,化学键的断裂等理化性质的改变,进而使水凝胶发生收缩,溶胀或降解。将治疗药物搭载于智能水凝胶后,这些根据环境变化而发生的凝胶理化性质的改变可促进药物的释放,从而对局部的疾病进行治疗,改善微环境的失衡。这种局部药物释放治疗为多种疾病如肿瘤、皮肤疾病及骨缺损等提供了新的方法。

关键词: 响应性水凝胶, 温敏性水凝胶, pH响应性水凝胶, 酶响应性水凝胶, 智能材料, 肿瘤, 药物递送, 靶向治疗, 微环境, 综述

Abstract:

BACKGROUND: Hydrogels play an important role in sustained release and targeted delivery of drugs. Because of the large variations in physiological conditions between normal microenvironment and diseased sites, normal hydrogels may not achieve the desired goals in a complex pathological microenvironment. Therefore, polymeric materials with environmentally responsive functions are highly desirable for drug delivery.
OBJECTIVE: We will introduce recent studies on stimuli-responsive hydrogels, describe the strategies of hydrogel synthesis and their application in drug delivery, and finally discuss the current research focus and future trends.
METHODS: A computer-based online search of PubMed, Web of Science, Medline, Wanfang and CNKI databases with the search terms “responsive hydrogel, temperature-responsive hydrogel, pH-responsive hydrogel hydrogel, drug delivery” for relevant papers published from 2007 to 2019.
RESULTS AND CONCLUSION: Initially, 352 papers were retrieved, and finally 62 of them were selected for further analysis. Environment-responsive intelligent hydrogels can be designed according to microenvironment changes such as temperature rising, pH value decreasing, overexpression of specific enzymes, and aggregation of redox agents. Changes in environment can reduce hydrogen bonds, increase charge repulsion, break chemical bonds, and other physical and chemical properties, thus causing hydrogel to shrink, swell, or degrade. After therapeutic drugs are loaded on the intelligent hydrogel, the environment-responsive changes in physical and chemical properties of the intelligent hydrogel can promote the release of drugs, thus treating local diseases and improving the imbalance of microenvironment. This local drug release therapy provides a new treatment method for various diseases such as tumors, skin diseases and bone defects.

Key words: responsive hydrogels, temperature-sensitive hydrogels, PH-responsive hydrogels, enzyme-responsive hydrogels, smart materials, tumors, drug delivery, targeted therapy, microenvironment, review

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