中国组织工程研究

中国组织工程研究 ›› 2019, Vol. 23 ›› Issue (10): 1501-1506.doi: 10.3969/j.issn.2095-4344.1614

• 组织工程口腔材料 tissue-engineered oral materials • 上一篇    下一篇

杜仲胶复合义齿软衬材料制备及吸水性和溶解性检测

罗 恒1，2，高 海1，许雪飞3，冯云枝2   

  1. 1南方医科大学口腔医院口腔修复科，广东省广州市 510280；2中南大学湘雅二医院口腔中心，湖南省长沙市 410012；3广州医科大学附属第二医院药学部，广东省广州市 510220
  • 收稿日期:2018-11-06 出版日期:2019-04-08 发布日期:2019-04-08
  • 通讯作者: 冯云枝，教授，中南大学湘雅二医院口腔中心，湖南省长沙市 410012
  • 作者简介:罗恒，男，1985年生，湖北省荆门市人，汉族，硕士，主治医师，主要从事口腔生物材料研究。

Preparation, water absorption and solubility of a new Eucommia ulmoides gum composite soft denture liner

Luo Heng1, 2, Gao Hai1, Xu Xuefei3, Feng Yunzhi2   

  1. 1Department of Prosthodontics, Stomatological Hospital, Southern Medical University, Guangzhou 510280, Guangdong Province, China; 2Department of Stomotology, the Second Xiangya Hospital, Central South University, Changsha 410012, Hunan Province, China; 3Department of Pharmacy, the Second Affiliated Hospital of Guangzhou Medical University, Guangzhou 510220, Guangdong Province, China
  • Received:2018-11-06 Online:2019-04-08 Published:2019-04-08
  • Contact: Feng Yunzhi, Professor, Department of Stomotology, the Second Xiangya Hospital, Central South University, Changsha 410012, Hunan Province, China
  • About author:Luo Heng, Master, Attending physician, Department of Prosthodontics, Stomatological Hospital, Southern Medical University, Guangzhou 510280, Guangdong Province, China; Department of Stomotology, the Second Xiangya Hospital, Central South University, Changsha 410012, Hunan Province, China

PDF

112

摘要：

文章快速阅读：

 

文题释义：
杜仲胶：提取自杜仲树的叶、皮和种子，主要成分为反式-1，4-聚异戊二烯，与天然橡胶互为同分异构体，同时也是天然橡胶的最佳替代品，具有巨大的开发前景。杜仲胶链结构具有3大特征：双键、柔性、反式结构，将杜仲胶变成弹性体后，具有天然橡胶和塑料的双重特性，性能独特，因此能够开发的领域和产品很多。
义齿软衬材料：是介于活动义齿硬基托与口腔黏膜组织面的一层软质、富有弹性的衬垫材料，它可通过自身变形吸收和减少传递到义齿承托区的功能性负荷，避免局部压力过大，减轻承托区覆盖的黏膜创伤和骨组织吸收，提高患者舒适感。目前临床上使用的软衬材料或多或少都存在着一些局限性，限制了它们的应用，主要原因就是由于其物理学性能上的缺陷。


背景：目前在临床上使用最普遍的软衬为硅橡胶类和丙烯酸树脂类，但2种材料均存在一定的不足，因此开发性质稳定、性能优良、兼具抗菌性的软衬材料具有重要临床意义。
目的：制备新型杜仲胶复合义齿软衬材料，同时评价其吸水性和溶解性。
方法：参考现有弹性杜仲胶配方和医用橡胶配方，结合义齿软衬材料的特殊要求，调整杜仲胶与顺丁橡胶的比例(混炼比例分别为10∶90，30∶70，50∶50，70∶30，90∶10)，制备新型杜仲胶复合义齿软衬材料，以丙烯酸自凝软衬材料和Silagum硅橡胶义齿软衬材料为对照，将各组样品分别置入人工唾液(或蒸馏水)中7，30 d，检测样品吸水性与溶解性。
结果与结论：①在人工唾液中：第7，30天，各实验组吸水率、溶解率均与硅橡胶组接近，远低于丙烯酸酯组；②在蒸馏水中：第7，30天，各实验组吸水率、溶解率均与硅橡胶组接近，远低于丙烯酸酯组；③在人工唾液或蒸馏水中：丙烯酸酯组浸泡第7，30天的吸水率、溶解率大于其余各组(P < 0.05)；④浸泡第7，30天时，同种试件在人工唾液中的吸水率低于在蒸馏水中的吸水率(P < 0.05)；浸泡第7天时，仅30∶70组、50∶50组试件在人工唾液中的溶解率低于在蒸馏水中的溶解率(P < 0.05)；浸泡第30 天时，30∶70组、  50∶50组、70∶30组、90∶10组试件在人工唾液中的溶解率低于在蒸馏水中的溶解率(P < 0.05)；⑤在人工唾液与蒸馏水中：同种试件浸泡第30 天的吸水率均大于第7天的吸水率(P < 0.05)；⑥在人工唾液中，  50∶50组浸泡第7，30天的溶解率比较无差异(P > 0.05)，70∶30组浸泡第7，30天的溶解率比较无差异(P > 0.05)，其他组组内不同时间点的溶解率比较差异显著(P < 0.05)；在蒸馏水中，10∶90组浸泡第7，30天的溶解率比较无差异(P > 0.05)，30∶70组浸浸泡第7，30天的溶解率比较无差异(P > 0.05)，其他组组内不同时间点的溶解率比较差异显著(P < 0.05)；⑦结果表明，杜仲胶复合义齿软衬材料的吸水性与Silagum硅橡胶软衬材料接近，显著低于丙烯酸酯软衬材料，且溶解性维持在较低水平。

ORCID: 0000-0002-3399-7148(罗恒)

 

关键词: 口腔材料, 杜仲胶, 软衬材料, 配方, 吸水性, 溶解性, 生物材料

Abstract:

BACKGROUND: The most common soft liners currently used in the clinic are silicone rubbers and acrylics, but both of them have deficiencies. Therefore, the development of soft lining materials with stability, excellent performance, and antibacterial properties is of important clinical significance.

OBJECTIVE: To prepare a soft lining material with high elasticity on the basis of excellent characteristics of Eucommia ulmoides gum, and to preliminarily explore its water absorption and solubility.
METHODS: The basic formula was made based on the existing formula of elastic Eucommia ulmoides gum and medical rubber, in combination with the specific requirements of denture lining materials. The ratio of Eucommia ulmoides to butadiene rubber was set to be 10:90, 30:70, 50:50, 70:30 and 90:10, and the new Eucommia ulmoides gum composite soft denture liners were then prepared. Acrylate self-curing soft lining material and Silagum silicone rubber denture soft lining material served as controls. Afterwards, the samples were put into distilled water or artificial saliva for 7 and 30 days, and the value of water absorption and water solubility were calculated.

RESULTS AND CONCLUSION: (1) In the artificial saliva for 7 and 30 days, the water absorption rate and solubility of samples in different ratio groups were close to those in the Silagum group, but extremely lower than those in the acrylate group. (2) In the distilled water for 7 and 30 days, the water absorption rate and solubility of samples in different ratio groups were close to those in the Silagum group, but extremely lower than those in the acrylate group. (3) The water absorption rate and solubility of the acrylate group were significantly higher than those in the other groups at 7 and 30 days of immersion in the artificial saliva or distilled water (P < 0.05). (4) After 7 and 30 days of immersion, the water absorption rate of the same sample in the artificial saliva was significantly lower than that in the distilled water. Wile at 7 days of immersion, the samples in the 30:70 and 50:50 groups showed a lower solubility in the artificial saliva than in the distilled water (P < 0.05), and at 30 days of immersion, the samples in the 30:70, 50:50, 70:30 and 90:10 groups showed a lower solubility in the artificial saliva than in the distilled water (P < 0.05). (5) In the artificial saliva, there was no significant difference in the solubility in the 50:50 and 70:30 groups at 7 and 30 days of immersion (P > 0.05), while the solubility in the other groups exhibited significant differences at different observational times (P < 0.05). In the distilled water, there was no significant difference in the solubility in the 10:90 and 30:70 groups at 7 and 30 days of immersion (P > 0.05), while the solubility in the other groups exhibited significant differences at different observational times (P < 0.05). To conclude, the water absorption of Eucommia ulmoides gum composite soft denture liner is close to Silagum, but significantly less than that of acrylate soft lining materials, and the solubility remains at a very low level.

中国组织工程研究杂志出版内容重点：生物材料；骨生物材料; 口腔生物材料; 纳米材料; 缓释材料; 材料相容性；组织工程

Key words: Gutta-Percha;, Denture Rebasing, Prosthodontics, Silicone Elastomers, Tissue Engineering

中图分类号: