中国组织工程研究 ›› 2018, Vol. 22 ›› Issue (25): 4095-4100.doi: 10.3969/j.issn.2095-4344.0428

• 干细胞综述 stem cell review • 上一篇    

丹酚酸B对骨髓间充质干细胞分化方向的影

李子怡,王 娜,薛 鹏,李玉坤   

  1. 河北医科大学第三医院内分泌二科,河北省石家庄市 050001
  • 修回日期:2017-12-15 出版日期:2018-09-08 发布日期:2018-09-08
  • 通讯作者: 李玉坤,博士,教授,河北医科大学第三医院内分泌二科,河北省石家庄市 050001
  • 作者简介:李子怡,女,1992年生,河北省保定市人,汉族,河北医科大学在读硕士,主要从事糖尿病与骨代谢研究。
  • 基金资助:

    河北省自然科学基金(H2016206243);2016年政府资助省级临床医学优秀人才项目(361005);河北省高等学校自然科学青年拔尖人才项目(BJ2016037)

Effect of salvianolic acid B on differentiation direction of bone marrow mesenchymal stem cells

Li Zi-yi, Wang Na, Xue Peng, Li Yu-kun   

  1. Department of Endocrinology, the Third Hospital of Hebei Medical University, Shijiazhuang 050001, Hebei Province, China
  • Revised:2017-12-15 Online:2018-09-08 Published:2018-09-08
  • Contact: Li Yu-kun, M.D., Professor, Department of Endocrinology, the Third Hospital of Hebei Medical University, Shijiazhuang 050001, Hebei Province, China
  • About author:Li Zi-yi, Master candidate, Department of Endocrinology, the Third Hospital of Hebei Medical University, Shijiazhuang 050001, Hebei Province, China
  • Supported by:

    the Natural Science Foundation of Hebei Province, No. H2016206243; 2016 Government-Funded Provincial-Level Clinical Talents Project, No. 361005; the Natural Science Top-Level Talents Project in Hebei Province, No. BJ2016037

摘要:

文章快速阅读:

文题释义:
丹酚酸B:
是丹参的重要水溶性成分,由三分子丹参素和一分子咖啡酸缩合而成,具有抗氧化、清除氧自由基等作用,对心血管系统、肝、肾等器官均具有重要的药理作用。
细胞分化:细胞分化发生在生命过程中的各个时期。指同一来源的细胞逐渐出现形态功能不同的亚群。其本质为时间和空间上基因组选择性表达。这种基因的表达不但受到细胞发育程序的调控,在很大程度上也受到外部环境的调控。

 

摘要
背景:
随着组织工程学的不断发展,骨髓间充质干细胞的多向分化潜能为多种疾病的治疗带来了新的希望。近年来的研究发现,丹参的主要有效成分丹酚酸B具有多种药理活性,可以影响骨髓间充质干细胞的定向分化。
目的:综述丹酚酸B对骨髓间充质干细胞分化方向的影响及具体机制。
方法:分别以“丹酚酸B、骨髓间充质干细胞/骨髓基质干细胞、分化”“Salvianolic acid B, differentiation/osteogenic/adipogenesis, mesenchymal stem cells”为检索词,由第一作者检索2000年1月至 2017 年 9 月在中国期刊全文数据库、PubMed 数据库及万方数据库发表的相关文章,其中中文102篇,英文136篇,最终选取具有代表性的49篇文献进行归纳总结。
结果与结论:目前发现,丹酚酸B可以促进骨髓间充质干细胞成骨分化、成神经分化、成心肌细胞分化,抑制骨髓间充质干细胞成脂分化。丹酚酸B是否可以促进骨髓间充质干细胞向其他方向分化及在促进不同分化方向上的有效浓度仍有待于进一步研究。

中国组织工程研究杂志出版内容重点:干细胞;骨髓干细胞;造血干细胞;脂肪干细胞;肿瘤干细胞;胚胎干细胞;脐带脐血干细胞;干细胞诱导;干细胞分化;组织工程
ORCID:
0000-0002-0706-1047(李子怡)

关键词: 丹酚酸B, 骨髓间充质干细胞, 干细胞, 分化, 成骨分化, 成脂分化, 成神经分化, 成心肌分化, 河北省自然科学基金

Abstract:

BACKGROUND: With the development of tissue engineering, the multi-directional differentiation potential of bone marrow mesenchymal stem cells has brought a new hope for the treatment of many diseases. Salvianolic acid B, as an effective component of Salvia miltiorrhiza Bunge, has many pharmacological activities influencing the directional differentiation of bone marrow mesenchymal stem cells.
OBJECTIVE: To summarize the effect of salvianolic acid B on the differentiation of bone marrow mesenchymal stem cells and to explore the underlying mechanisms.
METHODS: The first author searched the CNKI, WanFang and PubMed databases using the keywords of “salvianolic acid B, directional differentiation, mesenchymal stem cells” in Chinese and English, respectively, to retrieve relevant articles published from January 2000 to September 2017. One hundred and two Chinese articles and 136 English articles were initially retrieved. Repetitive articles or those with no originality were eliminated. Finally 49 articles were included in the result analysis.
RESULTS AND CONCLUSION: It has been found that salvianolic acid B can promote the osteogenic, neuronal and myocardial differentiation of bone marrow mesenchymal stem cells, but inhibit the adipogenic differentiation of the cells. Further investigations are required on whether salvianolic acid B can promote the mutli-directional differentiation of bone marrow mesenchymal stem cells and its effective concentrations. 

中国组织工程研究杂志出版内容重点:干细胞;骨髓干细胞;造血干细胞;脂肪干细胞;肿瘤干细胞;胚胎干细胞;脐带脐血干细胞;干细胞诱导;干细胞分化;组织工程

Key words: Salvia miltiorrhiza, Bone Marrow, Mesenchymal Stem Cells, Cell Differentiation, Review, Tissue Engineering

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