中国组织工程研究 ›› 2018, Vol. 22 ›› Issue (16): 2619-2624.doi: 10.3969/j.issn.2095-4344.0217

• 组织构建综述 tissue construction review • 上一篇    

临床与基础研究中实验室生物样本对接管理的主要问题及对策

程  酩1,姜  峰2   

  1. 1上海交通大学生物医学工程学院,上海市   200240;2上海交通大学医学院附属新华医院崇明分院/上海市崇明新华癌痛转化研究所,上海市  202150
  • 收稿日期:2018-01-23 出版日期:2018-06-08 发布日期:2018-06-08
  • 通讯作者: 姜峰,博士,助理研究员,上海交通大学医学院附属新华医院崇明分院/上海市崇明新华癌痛转化研究所,上海市 202150
  • 作者简介:程酩,男,1985年生,上海市人,汉族,2010年上海大学毕业,硕士,工程师,主要从事转化医学的研究。
  • 基金资助:

    上海交通大学医工交叉基金青年项目(YG2016QN66)

Management of biosamples transferred from hospitals to laboratories: main problems and solutions

Cheng Ming1, Jiang Feng2   

  1. 1School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai 200240, China; 2Chongming Branch of Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine & Xinhua Translational Institute for Cancer Pain, Shanghai 202150, China
  • Received:2018-01-23 Online:2018-06-08 Published:2018-06-08
  • Contact: Jiang Feng, M.D., Research assistant, Chongming Branch of Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine & Xinhua Translational Institute for Cancer Pain, Shanghai 202150, China
  • About author:Cheng Ming, Master, Engineer, School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai 200240, China
  • Supported by:

    the Medical Cross Foundation for the Youth of Shanghai Jiao Tong University, No. YG2016QN66

摘要:

文章快速阅读:

文题释义:
转化医学:是将临床实践与基础医学研究连接起来的一种新的思维方式。从临床实际问题出发,到实验室进行研究;再将实验室研究成果返回临床应用;搭建“转化”的桥梁,将医学和生命科学之间有效的连接起来。
知识产权:是指人类在社会实践中创造的智力劳动成果的专有权利。本文所涉及的知识产权通常是指基础研究工作者利用临床医师提供的,用于科学研究的人体生物样本产生的知识产权。
摘要
背景
:转化医学实现需要临床医师与基础研究者的密切合作。疾病相关的人体生物样本是转化医学研究的重要资源,是实现转化的核心环节。
目的:分析临床医师与基础研究者合作开展转化医学研究的必要性,并就临床与基础研究实验室生物样本对接管理中的主要问题及策略进行了探讨。
方法:英文检索词设定为“Translational medical research,biosample,biobank”;中文检索词设定为“转化医学,生物样本,生物样本库”。检索中国知网、维普资讯、万方数据、PubMed数据库2010年1月至2016年12月相关的文献124篇,选取其中部分文献及作者所在单位与其他单位的科研合作经验进行分析探讨。
结果与结论:临床与基础研究实验室生物样本对接管理中可能遇到的问题,包括生物样本采集的伦理问题、标准操作流程的设定、生物样本的采集、运输、保存、登记、管理以及有关生物样本的知识产权分割等,医学标准化,高质量的疾病相关的人体生物样本是实现转化医学的核心环节。建立完善的利益共享机制,对于做好临床与基础研究实验室生物样本对接管理,后续转化医学研究工作的顺利进行将起到至关重要的作用。

中国组织工程研究杂志出版内容重点:组织构建;骨细胞;软骨细胞;细胞培养;成纤维细胞;血管内皮细胞;骨质疏松组织工程
ORCID: 0000-0002-3255-0379(程酩)

关键词: 转化医学, 临床医师, 基础研究者样本对接管理, 组织构建

Abstract:

BACKGROUND: Translational medical research realization needs close collaboration between clinicians and basic scientists. Human disease-related biological samples play a key role in the translational medical research.
OBJECTIVE: To discuss the necessity of the cooperation between clinicians and scientists, and to discuss the main problems in the management of biosamples that transferred from hospitals to laboratories.
METHODS: The keywords were “translational medical research, biosample, biobank” in English and Chinese, respectively. CNKI, VIP, WanFang and PubMed databases were retrieved for the literature published from January 2010 to December 2016. Totally 124 eliglible articles were included, and some of them were selected to analyze the cooperation between clinicians and scientists
RESULTS AND CONCLUSION: Problems in the management of bio-samples that transferred from hospitals to basic research laboratories include ethics, standardized operation, as well as collection, transport, preservation, management and intellectual property of bio-samples. Standard biosamples with high quality is the key to translational medical research. Establishing a perfect interests-coordination mechanism is of great significance for the management of biosamples that transferred from hospitals to laboratories and translational medical research.

中国组织工程研究杂志出版内容重点:组织构建;骨细胞;软骨细胞;细胞培养;成纤维细胞;血管内皮细胞;骨质疏松组织工程

Key words: Clinical Medicine, Laboratories, Transportation, Preservation, Biological, Tissue Engineering

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