中国组织工程研究 ›› 2017, Vol. 21 ›› Issue (21): 3407-3413.doi: 10.3969/j.issn.2095-4344.2017.21.021

• 干细胞综述 stem cell review • 上一篇    下一篇

骨髓间充质干细胞修复辐射造血损伤的机制

郭德镔1,2,朱向情1,潘兴华1   

  1. 1干细胞与免疫细胞生物医药技术国家地方联合工程实验室,云南省昆明市 650032;2解放军第三军医大学,重庆市 400037
  • 修回日期:2017-02-13 出版日期:2017-07-28 发布日期:2017-08-02
  • 通讯作者: 潘兴华,博士,主任医师,解放军昆明总医院干细胞工程实验室,云南省昆明市 650032
  • 作者简介:郭德镔,女,1989年生,云南省保山市人,汉族,2015年解放军第三军医大学在读硕士,检验技师,主要从事干细胞治疗放射损伤基础研究。
  • 基金资助:

    国家科技支撑计划项目(2014BI01B0);昆明市重点项目(2015-1-S-00973);云南省战略性新兴产业专项(2013DA004);全军实验动物专项(SYDW[2014]003)

Underlying mechanism of bone marrow mesenchymal stem cells in the repair of radiation-induced hematopoietic injury

Guo De-bin1, 2, Zhu Xiang-qing1, Pan Xing-hua1   

  1. 1Stem Cell and Immune Cells Biomedical Techniques Integrated Engineering Laboratory of State and Regions, Kunming 650032, Yunnan Province, China; 2the Third Military Medical University of PLA, Chongqing 400037, China
  • Revised:2017-02-13 Online:2017-07-28 Published:2017-08-02
  • Contact: Pan Xing-hua, M.D., Chief physician, Stem Cell and Immune Cells Biomedical Techniques Integrated Engineering Laboratory of State and Regions, Kunming 650032, Yunnan Province, China
  • About author:Guo De-bin, Studying for master’s degree, Inspector, Stem Cell and Immune Cells Biomedical Techniques Integrated Engineering Laboratory of State and Regions, Kunming 650032, Yunnan Province, China; the Third Military Medical University of PLA, Chongqing 400037, China
  • Supported by:

    the National Science and Technology Support Program of China, No. 2014BI01B0; the Key Project of Kunming City, No. 2015-1-S-00973; the Special Project of Strategic Emerging Industries in Yunnan Province, No. 2013DA004; the Special Project of Experimental Animals in PLA, No. SYDW [2014]003

摘要:

文章快速阅读:

文题释义:
造血干细胞龛:
造血干细胞聚集和相互作用的特定微环境。
骨髓间充质干细胞保护造血干细胞的机制:①组织特异性细胞:如骨髓间充质干细胞可能分化成造血干细胞、血管内皮细胞修复造血组织;②功能相关性细胞:如干细胞移植中,骨髓间充质干细胞作为骨髓微环境或者造血干细胞龛的重要组分,促进造血干细胞的归巢、再生与功能发挥;③调节性细胞:如骨髓间充质干细胞通过分泌各种细胞因子调节免疫与炎症反应,促进造血细胞的生长与归巢。

 

摘要
背景:
骨髓间充质干细胞与造血干细胞共移植,可提高辐射损伤的生存率。
目的:对骨髓间充质干细胞在辐射损伤后造血重建及免疫调节方面的研究机制作一综述。
方法:以“mesenchymalstem cells,radiation,radiation injury,hematopoietic stem cells,hematopoietic reconstitution,immunomodulatory”为关键词,应用计算机检索Web of science数据库2005到2016年的文献,选择性纳入与文章主题密切相关的文献。
结果与结论:骨髓间充质干细胞能通过自噬及快速启动HR/NHEJ途径修复DNA断裂双键,通过细胞间相互作用、旁分泌作用保护与支持造血干细胞,通过抑制炎症与免疫反应维持造血微环境稳态,有效修复电离辐射导致的造血损伤。所以间充质干细胞可能有资格作为辐射导致的造血损伤的有效治疗手段。

 

 

关键词: 干细胞, 骨髓干细胞, 间充质干细胞, 电离辐射, 辐射损伤, 造血干细胞, 造血重建, 免疫调节

Abstract:

BACKGROUND: Co-transplantation of bone marrow mesenchymal stem cells (BMSCs) and hematopoietic stem cells (HSCs) can improve the survival rate following radiation damage.
OBJECTIVE: To review the mechanisms of BMSCs in hematopoietic reconstitution and immunomodulation after radiation damage.
METHODS: Relevant articles included in the Web of science from 2005 to 2016 were retrieved, and the keywords were “mesenchymal stem cells; radiation; radiation injury; hematopoietic stem cells; hematopoietic reconstitution; immunomodulatory” in English. Then we sorted and analyzed the articles which were closely related to the theme.
RESULTS AND CONCLUSION: BMSCs can repair broken DNA double bonds by autophagy and HR/NHEJ pathway; support and protect HSCs by intercellular interactions and paracrine action; and repair radiation-induced hematopoietic injury by inhibiting inflammation and immune responses to maintain HSC homeostasis. Therefore, BMSCs may function as an effective treatment for radiation-induced hematopoietic injury.

 

 

Key words: Mesenchymal Stem Cells, Hematopoietic Stem Cells, Radiation, Ionizing, Immunomodulation, Tissue Engineering

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