中国组织工程研究 ›› 2017, Vol. 21 ›› Issue (21): 3414-3419.doi: 10.3969/j.issn.2095-4344.2017.21.022

• 干细胞综述 stem cell review • 上一篇    下一篇

乳腺癌干细胞近年的主要研究进展

罗智萍1,2,刘碧珊2,谭宁华1   

  1. 1中国药科大学中药学院,江苏省南京市 211198;2香港中文大学中医中药研究所及植物化学与西部植物资源持续利用国家重点实验室伙伴实验室,中国香港
  • 修回日期:2017-06-13 出版日期:2017-07-28 发布日期:2017-08-02
  • 通讯作者: 谭宁华,博士,教授,博士生导师,中国药科大学中药学院,江苏省南京市 211198
  • 作者简介:罗智萍,女,1991年生,河南省睢县人,汉族,2017年中国药科大学毕业,硕士,主要从事中药活性成分研究。
  • 基金资助:

    中国药科大学高层次人才引进项目(1050020013,3010020056,3010020057);国家自然科学基金项目(31470428)

Some recent progress on breast cancer stem cells

Luo Zhi-ping1, 2, Lau Clara Bik-san2, Tan Ning-hua1   

  1. 1School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing 211198, Jiangsu Province, China; 2Institute of Chinese Medicine and Partner State Key Laboratory of Phytochemistry and Plant Resources in West China, The Chinese University of Hong Kong, Hong Kong SAR, China
  • Revised:2017-06-13 Online:2017-07-28 Published:2017-08-02
  • Contact: Tan Ning-hua, Ph.D., Professor, Doctoral supervisor, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing 211198, Jiangsu Province, China
  • About author:Luo Zhi-ping, Master, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing 211198, Jiangsu Province, China
  • Supported by:

    the Foundation of High-level Talent Introduction Projects of China Pharmaceutical University, No. 1050020013, 3010020056, 3010020057; the National Natural Science Foundation of China, No. 31470428

摘要:

文章快速阅读:

文题释义:
乳腺癌干细胞的转移:
乳腺癌干细胞具有很强的细胞迁移能力,相比实体肿瘤细胞,乳腺癌干细胞更易从原发部位脱离,迁移并侵袭进入淋巴管或血管,随循环到达远处器官,其自我更新能力使肿瘤干细胞大量增殖并分化,最后造成乳腺癌的转移。
乳腺癌干细胞的特点:乳腺癌干细胞具有无限自我更新能力,可以产生异质性肿瘤细胞,乳腺癌干细胞具有多向分化潜能,并具有高度致瘤性,200个左右的乳腺癌干细胞就可以在小鼠移植瘤模型中形成肿瘤,乳腺癌干细胞对常规的化疗药物具有耐药性,同时乳腺癌干细胞具有很强的迁移和侵袭能力。

 

摘要
背景:
随着对乳腺癌发生、发展机制的不断深入研究,乳腺癌干细胞日益受到重视。
目的:对乳腺癌干细胞的特征、调控乳腺癌干细胞的相关信号通路以及乳腺癌干细胞与上皮间质转化、乳腺癌转移、肿瘤微环境、治疗抵抗等方面的主要研究进展做一综述。
方法:由第一作者以“Breast cancer,Stem cells,Signaling pathway,Epithelial mesenchymal transition,Tumor microenvironment”为关键词,检索PubMed等数据库从2001至2017年的相关文献,排除与文章研究目的无关及重复性的文章,纳入符合标准的60篇文献进行综述。
结果与结论:肿瘤干细胞学说的提出解释了肿瘤转移和复发的根本原因,为肿瘤治疗提供一个新的研究思路,随着对乳腺癌干细胞的致病分子机制、特性和相关分子调控机制的深入研究,明确了乳腺癌干细胞在乳腺癌发生、发展中所扮演的角色,对靶向乳腺癌干细胞的肿瘤治疗方法的研究具有重要指导意义。

 

 

 

关键词: 干细胞, 肿瘤干细胞, 乳腺癌, 转移, 复发, 致瘤性, 分离鉴定, 信号通路, 上皮间质转化, 肿瘤微环境, 耐药性, 国家自然科学基金

Abstract:

BACKGROUND: With the in-depth exploration of the mechanism of breast cancer occurrence and increasing attention has been paid to breast cancer stem cell development.
OBJECTIVE: To review the main progress in the characteristics, related signaling pathways, epithelial- mesenchymal transition, breast cancer metastasis and tumor microenvironment about breast cancer stem cells.
METHODS: A computer-based retrieval of PubMed database was performed in order to search relevant articles published from 2001 to 2017, using the keywords of “breast cancer, stem cells, signaling pathway, epithelial- mesenchymal transition, tumor microenvironment”. After removal of repetitive or irrelevant articles, 60 articles were finally reviewed.
RESULTS AND CONCLUSION: The tumor stem cell theory explains the root cause of tumor metastasis and recurrence, and provides a new insight into the tumor treatment. With the further study on the molecular pathogenesis, characteristics and related molecular regulation mechanisms of breast cancer stem cells, the role of breast cancer stem cells is explicated in the development and progression of breast cancer, which is of great significance in the tumor treatment targeting breast cancer stem cells.

 

 

Key words: Breast Neoplasms, Neoplastic Stem Cells, Tissue Engineering

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