中国组织工程研究

中国组织工程研究 ›› 2016, Vol. 20 ›› Issue (38): 5758-5763.doi: 10.3969/j.issn.2095-4344.2016.38.020

• 生物材料综述 biomaterial review • 上一篇    下一篇

医用热熔胶的研究与应用

郑  萌1，罗  鑫1，陈婧泠1，石淑先1，刘建东2，陈晓农1
  

  1. 1北京化工大学生物医用材料北京实验室，北京市  100029；2雷诺丽特塑料科技(北京)有限公司，北京市  101407
  • 收稿日期:2016-07-05 出版日期:2016-09-16 发布日期:2016-09-16
  • 通讯作者: 陈晓农，教授，博士生导师，北京化工大学生物医用材料北京实验室，北京市 100029
  • 作者简介:郑萌，女，1990年生，陕西省榆林市人，汉族，北京化工大学在读硕士。
  • 基金资助:
    北京市科学技术委员会科研计划项目(Z141100003814001)

Hot-melt adhesives for medical applications

Zheng Meng1, Luo Xin1, Chen Jing-ling1, Shi Shu-xian1, Liu Jian-dong2, Chen Xiao-nong1
  

  1. 1Beijing Laboratory of Biomedical Materials, Beijing University of Chemical Technology, Beijing 100029, China; 2RENOLIT Plastic Tech (Beijing) Ltd., Beijing 101407, China
  • Received:2016-07-05 Online:2016-09-16 Published:2016-09-16
  • Contact: Chen Xiao-nong, Professor, Doctoral supervisor, Beijing Laboratory of Biomedical Materials, Beijing University of Chemical Technology, Beijing 100029, China
  • About author:Zheng Meng, Studying for master’s degree, Beijing Laboratory of Biomedical Materials, Beijing University of Chemical Technology, Beijing 100029, China
  • Supported by:
     the Research and Developmental Project of the Science and Technology Commission of Beijing Municipality, No. Z141100003814001

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被引次数

1

摘要：

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文题释义：
热熔胶：是一种以热塑性树脂为基料并添加少量增塑剂、增黏剂、填料、抗氧剂等，利用温度变化实施粘接的胶黏剂。按主体树脂的不同，可将热熔胶分为乙烯-醋酸乙烯酯类、苯乙烯嵌段弹性体类、聚烯烃类、聚酰胺类、聚酯类等。
热塑性弹性体热熔胶：主要是指苯乙烯及其嵌段共聚物类热熔胶，主要成分是热塑性高分子弹性体，如苯乙烯-丁二烯-苯乙烯、苯乙烯-异戊二烯-苯乙烯等芳族乙烯-共轭二烯-芳族乙烯三嵌段共聚物，并添加少量增塑剂、增黏剂、填料及抗氧剂等。

背景：热熔胶属无溶剂型黏合剂，安全环保，适合应用于医用领域。
目的：阐述目前主要医用热熔胶的特点，同时展望体内聚烯烃医用导管热熔粘接技术的研发方向，指出相应热熔胶的技术关键点。
方法：应用计算机检索1995年1月至2015年12月SCI、Elsevier及中国知网数据库相关文献或专利，检索词为“热熔胶，医学应用，hot melt adhesive，medical application”。
结果与结论：目前文献中报道的医用热熔胶主要有4类，即无定型聚烯烃热熔胶、热塑性弹性体热熔胶、丙烯酸酯类热熔胶与聚氨酯类热熔胶。大多数热熔胶在耐热性方面都难以达到医学上常用水蒸汽灭菌温度所要求的耐热性。为此，针对体内医用导管连接需求，提出聚烯烃医用热熔胶研究思路，关键是要选用熔点适宜的无规共聚聚丙烯基材，通过配合助剂的调节，使得热熔胶熔化温度低于管材聚烯烃材料的熔点，而又能经受水蒸汽灭菌的温度，确保在实施熔融粘接时导管不变形，灭菌时粘接层不失效。 

关键词: 生物材料, 材料相容性, 热熔胶, 医用, 聚合物基材, 配方, 性能, 展望

Abstract:

BACKGROUND: Hot-melt adhesive is safe and environmental friendly adhesive due to free of solvent, which is particularly suitable for medical applications.
OBJECTIVE: To describe the types and characteristics of currently used hot-melt adhesives and to prospect the technical research and development of hot-melt adhesive for polyolefin tubes or catheters as well as to point out the corresponding key points to the hot-melt adhesion.
METHODS: Literature search was carried out in SCI, Elsevier, and CNKI with the key words of “hot melt adhesive, medical application” in English and Chinese, respectively, for the initial retrieval of relevant articles or patents published January 1995 to December 2015.
RESULTS AND CONCLUSION: To date, the medical hot-melt adhesives reported in the literature could be grouped as amorphous polyolefin, thermoplastic elastomer, acrylic and polyurethane types. The heat resistance of the most of the hot-melt adhesives does not meet the requirement for steam sterilizing process. In the present review, a strategy is proposed to develop a novel hot-melt adhesive which is good for binding polyolefin parts and can undergo the sterilization process. Given this, it is essential to choose a kind of polypropylene random copolymer with a suitable melting point as a substrate. With the aid of an adjuvant agent, therefore, we can develop a novel hot-melt adhesive that exhibits a lower melting point than the polyolefin tube, withstands steam sterilization temperature to ensure that the tube is not deformed during melt adhesion and is not become invalid during sterilization. 

Key words: Polymers, Polypropylenes, Tissue Engineering

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