中国组织工程研究 ›› 2013, Vol. 17 ›› Issue (14): 2544-2551.doi: 10.3969/j.issn.2095-4344.2013.14.011

• 干细胞移植 stem cell transplantation • 上一篇    下一篇

血管成形与脐带干细胞移植治疗糖尿病足:3个月血管造影评价

秦汉林1,贺克武1,高  斌1,季亚莉2,黄永翠2,王胜琴2,胡国平2,周学勇2   

  1. 1合肥市第一人民医院介入科,安徽省合肥市  236001
    2安徽省血液中心,安徽省合肥市  236001
  • 收稿日期:2012-10-25 修回日期:2012-11-29 出版日期:2013-04-02 发布日期:2013-04-02
  • 通讯作者: 高斌,主任医师,主要从事外周血管病介入治疗。合肥市第一人民医院介入科,安徽省合肥市 236001
  • 作者简介:秦汉林★,男,1983年生,安徽省利辛县人,汉族,2011年徐州医学院毕业,硕士,主治医师,主要从事外周血管病介入治疗方面的研究。
  • 基金资助:

    安徽省科技厅年度计划项目(09020303043)。

Human umbilical cord mesenchymal stem cell transplantation combined with angioplasty for diabetic foot: 3 months angiographic evaluation

Qin Han-lin1, He Ke-wu1, Gao Bin1, Ji Ya-li2, Huang Yong-cui2, Wang Sheng-qin2, Hu Guo-ping2, Zhou Xue-yong2   

  1. 1 Department of Interventional Radiology, First People’s Hospital of Hefei City, Hefei  230061, Anhui Province, China
    2 Blood Center of Anhui Province, Hefei  236001, Anhui Province, China
  • Received:2012-10-25 Revised:2012-11-29 Online:2013-04-02 Published:2013-04-02
  • Contact: Gao Bin, Chief physician, Department of Interventional Radiology, First People’s Hospital of Hefei City, Hefei 230061, Anhui Province, China gaobinrm@hotmail.com
  • About author:Qin Han-lin★, Master, Attending physician, Department of Interventional Radiology, First People’s Hospital of Hefei City, Hefei 230061, Anhui Province, China qinhanlin18@sina.com
  • Supported by:

    Annual Planning Project of Anhui Science and Technology Department, No. 09020303043

摘要:

背景:目前对糖尿病继发肢体动脉闭塞尚无有效的药物治疗,最终多导致截肢,预后很差。
目的:以血管成形联合人脐带间充质干细胞移植治疗糖尿病足,3个月后行血管造影评价效果。
方法:确诊症状严重伴有下肢动脉不同程度病变的Fontain Ⅳ期糖尿病足40例52条患肢,对照组12例患者18条患肢给予单纯介入治疗,实验组28例34条患肢给予介入联合人脐带间充质干细胞经导管灌注及溃疡周围注射治疗,随访3个月。
结果与结论:治疗后患肢冷感、疼痛、麻木等临床症状持续改善,患肢皮温、踝肱指数值及跛行距离均增加。治疗3个月后复查造影,新生血管增多,溃疡逐渐愈合或缩小,输注前后未出现严重并发症和不良反应。说明采用血管成形联合人脐带间充质干细胞移植治疗糖尿病足,方法可行、安全,近期疗效满意。

关键词: 干细胞, 干细胞移植, 2型糖尿病, 外周血管病变, 糖尿病足, 溃疡, 介入, 血管成形, 人脐带间充质干细胞, 移植, 疗效, 并发症, 省级基金, 干细胞图片文章

Abstract:

BACKGROUND: At present, there is no effective drug for the treatment of diabetic arteniosclerosis obliterons, and most of the patients have to receive amputation, and have poor prognosis.
OBJECTIVE: To treat the diabetic foot with human umbilical cord mesenchymal stem cells transplantation combined with angioplasty, and to perform the angiographic evaluation at 3 months after operation.
METHODS: Forty cases (52 limbs) diagnosed with severe symptoms of Fontain Ⅳ diabetic foot accompanied with varying degrees of lower extremity arterial disease were included. The 12 cases (18 limbs) in the control group received simple interventional treatment, and 28 cases (34 limbs) in the experimental group were given human umbilical cord mesenchymal stem cells endovascular infusion and injection around the ulcer. Then all the patients were followed-up for 3 months.  
RESULTS AND CONCLUSION: Local cool-feeling, pain and numbness after treatment were improved continuously in a certain extent; skin temperature, ankle-brachial pressure index and claudication distance were improved persistently. Re-examination angiography at 3 months after treatment showed that the neovessels were increased significantly and the ulcer was healed or decreased gradually. No serious complications and adverse reactions were observed before and after infusion. The results indicate that human umbilical cord mesenchymal stem cell transplantation combined with angioplasty is a safe, effective and satisfactory method for severe diabetic foot.

Key words: stem cells, stem cell transplantation, type 2 diabetes, peripheral vascular disease, diabetic foot, ulcer, intervention, angioplasty, human umbilical cord mesenchymal stem cells, transplantation, efficacy, complications, provincial grants-supported paper, stem cell photographs-containing paper

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