中国组织工程研究 ›› 2013, Vol. 17 ›› Issue (14): 2544-2551.doi: 10.3969/j.issn.2095-4344.2013.14.011
• 干细胞移植 stem cell transplantation • 上一篇 下一篇
秦汉林1,贺克武1,高 斌1,季亚莉2,黄永翠2,王胜琴2,胡国平2,周学勇2
收稿日期:
2012-10-25
修回日期:
2012-11-29
出版日期:
2013-04-02
发布日期:
2013-04-02
通讯作者:
高斌,主任医师,主要从事外周血管病介入治疗。合肥市第一人民医院介入科,安徽省合肥市 236001
作者简介:
秦汉林★,男,1983年生,安徽省利辛县人,汉族,2011年徐州医学院毕业,硕士,主治医师,主要从事外周血管病介入治疗方面的研究。
基金资助:
安徽省科技厅年度计划项目(09020303043)。
Qin Han-lin1, He Ke-wu1, Gao Bin1, Ji Ya-li2, Huang Yong-cui2, Wang Sheng-qin2, Hu Guo-ping2, Zhou Xue-yong2
Received:
2012-10-25
Revised:
2012-11-29
Online:
2013-04-02
Published:
2013-04-02
Contact:
Gao Bin, Chief physician, Department of Interventional Radiology, First People’s Hospital of Hefei City, Hefei 230061, Anhui Province, China
gaobinrm@hotmail.com
About author:
Qin Han-lin★, Master, Attending physician, Department of Interventional Radiology, First People’s Hospital of Hefei City, Hefei 230061, Anhui Province, China
qinhanlin18@sina.com
Supported by:
Annual Planning Project of Anhui Science and Technology Department, No. 09020303043
摘要:
背景:目前对糖尿病继发肢体动脉闭塞尚无有效的药物治疗,最终多导致截肢,预后很差。 目的:以血管成形联合人脐带间充质干细胞移植治疗糖尿病足,3个月后行血管造影评价效果。 方法:确诊症状严重伴有下肢动脉不同程度病变的Fontain Ⅳ期糖尿病足40例52条患肢,对照组12例患者18条患肢给予单纯介入治疗,实验组28例34条患肢给予介入联合人脐带间充质干细胞经导管灌注及溃疡周围注射治疗,随访3个月。 结果与结论:治疗后患肢冷感、疼痛、麻木等临床症状持续改善,患肢皮温、踝肱指数值及跛行距离均增加。治疗3个月后复查造影,新生血管增多,溃疡逐渐愈合或缩小,输注前后未出现严重并发症和不良反应。说明采用血管成形联合人脐带间充质干细胞移植治疗糖尿病足,方法可行、安全,近期疗效满意。
中图分类号:
秦汉林,贺克武,高 斌,季亚莉,黄永翠,王胜琴,胡国平,周学勇. 血管成形与脐带干细胞移植治疗糖尿病足:3个月血管造影评价[J]. 中国组织工程研究, 2013, 17(14): 2544-2551.
Qin Han-lin, He Ke-wu, Gao Bin, Ji Ya-li, Huang Yong-cui, Wang Sheng-qin, Hu Guo-ping, Zhou Xue-yong. Human umbilical cord mesenchymal stem cell transplantation combined with angioplasty for diabetic foot: 3 months angiographic evaluation[J]. Chinese Journal of Tissue Engineering Research, 2013, 17(14): 2544-2551.
Changes in the number of participants (Table 1)
All the patients with diabetic foot were included in the final analysis without any loss, including 28 patients (34 limbs) in the experimental group, and 12 patients (18 limbs) in the control group.
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1 人脐带间充质干细胞输注是近几年兴起的一种治疗缺血性糖尿病足的新方法,但经皮血管成形联合人脐带间充质干细胞治疗糖尿病足尚未见文献报道。 2 把干细胞输注与经皮血管成形联合起来,二者取长补短,既能开通大的狭窄或闭塞血管又能促进患肢小血管再生,从根本上改善微循环,进一步提高糖尿病足溃疡的愈合率。 基金项目: 安徽省科技厅年度计划项目(09020303043)。
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