间充质干细胞治疗骨关节炎软骨损伤：作用、应用与问题

doi:10.12307/2021.150

中国组织工程研究 ›› 2021, Vol. 25 ›› Issue (31): 5053-5058.doi: 10.12307/2021.150

• 干细胞综述 stem cell review • 上一篇下一篇

间充质干细胞治疗骨关节炎软骨损伤：作用、应用与问题

王新伟，赵英杰，常艳，魏伟

安徽医科大学临床药理研究所，抗炎免疫药物教育部重点实验室，安徽省高校抗炎免疫药物协同创新中心，安徽省合肥市 230032

收稿日期:2020-05-08 修回日期:2020-05-13 接受日期:2020-09-05 出版日期:2021-11-08 发布日期:2021-04-25
通讯作者: 常艳，博士，教授，安徽医科大学临床药理研究所，抗炎免疫药物教育部重点实验室，安徽省高校抗炎免疫药物协同创新中心，安徽省合肥市 230032
作者简介:王新伟，男，1995年生，安徽省六安市人，汉族，安徽医科大学在读硕士，主要从事骨关节炎软骨损伤修复与间充质干细胞临床应用研究。
基金资助:
国家自然科学基金面上项目(81573443，81673444)，项目负责人：常艳；安徽省自然科学杰出青年基金(170808J10)，项目负责人：常艳；2016年高校优秀青年人才支持计划重点项目(gxyqZD2016043)，项目负责人：常艳

Mesenchymal stem cells in the treatment of cartilage damage in osteoarthritis: role, application, and problem

Wang Xinwei, Zhao Yingjie, Chang Yan, Wei Wei

Institute of Clinical Pharmacology, Anhui Medical University; Key Laboratory of Antiinflammatory and Immune Medicine, Ministry of Education; Anhui University Collaborative Innovation Center for Antiinflammatory and Immune Drugs; Hefei 230032, Anhui Province, China

Received:2020-05-08 Revised:2020-05-13 Accepted:2020-09-05 Online:2021-11-08 Published:2021-04-25
Contact: Chang Yan, MD, Professor, Institute of Clinical Pharmacology, Anhui Medical University; Key Laboratory of Antiinflammatory and Immune Medicine, Ministry of Education; Anhui University Collaborative Innovation Center for Antiinflammatory and Immune Drugs; Hefei 230032, Anhui Province, China
About author:Wang Xinwei, Master candidate, Institute of Clinical Pharmacology, Anhui Medical University; Key Laboratory of Antiinflammatory and Immune Medicine, Ministry of Education; Anhui University Collaborative Innovation Center for Antiinflammatory and Immune Drugs; Hefei 230032, Anhui Province, China
Supported by:
the National Natural Science Foundation of China, No. 81573443, 81673444 (to CY); the Anhui Province Natural Science Fund (Outstanding Youth), No. 170808J10 (to CY); the Key Projects of Outstanding Young Talent Support Program in Colleges and Universities in 2016, No. gxyqZD2016043 (to CY)

摘要/Abstract

摘要：

文题释义：

间充质干细胞：是一种具有自我更新和多向分化潜能的干细胞，最初于骨髓中被发现，现可来源于多种组织，生物学性能稳定。
骨关节炎软骨损伤：骨关节炎是一种关节退行性疾病，临床表现为慢性关节疼痛、关节僵硬和关节肿胀。骨关节炎的主要病理特征是关节软骨的退行性病变，随着年龄的增长以及其他因素如慢性劳损、肥胖和创伤等导致关节软骨受损，进一步发展为关节软骨病变，演变为骨关节炎。关节软骨是一种结构组成特殊的结缔组织，关节软骨内不含血管和神经系统，受到损伤后不具备自我修复能力。目前的治疗方式包括药物、手术和自体软骨细胞移植，但只能起到缓解作用，对软骨的再生效果很弱。间充质干细胞可实现关节软骨再生，为治疗骨关节炎软骨损伤提供了新的选择。
背景：间充质干细胞来源广泛、易于分离培养，并且具有多向分化、组织修复、抗炎和免疫调节功能，为治疗骨关节炎软骨损伤提供新的途径。
目的：对间充质干细胞治疗骨关节炎软骨损伤的应用和研究方面作一综述。
方法：由第一作者以“osteoarthritis，cartilage damage，mesenchymal stem cell，treatment”为英文关键词，以“间充质干细胞，骨关节炎，软骨损伤，治疗”为中文关键词，检索2000至2020年期间收录在 PubMed和中国知网数据库中的相关文献，排除与文章研究目的无关及重复性的文献，对纳入符合标准的50篇文献进行综述。
结果与结论：①组织工程方法将间充质干细胞的多向分化功能和生物支架材料的特性结合，能够更好地促进受损软骨的修复，已在基础研究和临床研究上取得了众多成果；②间充质干细胞与溶媒联用关节腔注射可以充分发挥间充质干细胞的治疗作用，而且可以将间充质干细胞的优点扩大；③间充质干细胞外泌体治疗骨关节软骨损伤目前还停留在临床前动物研究阶段，但有希望成为骨关节炎软骨损伤治疗的新手段。
https://orcid.org/0000-0002-8271-5602(王新伟)

中国组织工程研究杂志出版内容重点：干细胞；骨髓干细胞；造血干细胞；脂肪干细胞；肿瘤干细胞；胚胎干细胞；脐带脐血干细胞；干细胞诱导；干细胞分化；组织工程

关键词: 干细胞, 间充质干细胞, 骨关节炎, 软骨损伤, 治疗, 组织工程, 综述

Abstract: BACKGROUND: Mesenchymal stem cells have a wide range of sources and are easy to be isolated and cultured. It also has the functions of multidirectional differentiation, tissue repair, anti-inflammatory and immune regulation, which provides a new approach for the treatment of articular cartilage injury.
OBJECTIVE: To review the application and research of mesenchymal stem cells in the treatment of osteoarthritis cartilage damage.
METHODS: Using “osteoarthritis, cartilage damage, mesenchymal stem cell, treatment” as the English and Chinese keywords, the first author retrieved the included in PubMed and CNKI databases from 2000 to 2020. After excluding articles that were not relevant and repetitive for the purpose of the article, fifty articles were included for review in the end.
RESULTS AND CONCLUSION: (1) Tissue engineering methods combined the multi-differentiation function of mesenchymal stem cells with the characteristics of bioscaffold materials can better promote the repair of damaged cartilage, and has made many achievements in basic research and clinical research. (2) Joint injection of mesenchymal stem cells with the solvent can exert the therapeutic effect and expand the advantages of mesenchymal stem cells. (3) Mesenchymal stem cell exosome for the therapy of osteoarthritis cartilage damage is still in the basic stage, which will become the developmental trend of osteoarthritis cartilage damage treatment.

Key words: stem cells, mesenchymal stem cells, osteoarthritis, cartilage injury, treatment, tissue engineering, review

中图分类号:

王新伟, 赵英杰, 常艳, 魏伟. 间充质干细胞治疗骨关节炎软骨损伤：作用、应用与问题[J]. 中国组织工程研究, 2021, 25(31): 5053-5058.

Wang Xinwei, Zhao Yingjie, Chang Yan, Wei Wei. Mesenchymal stem cells in the treatment of cartilage damage in osteoarthritis: role, application, and problem[J]. Chinese Journal of Tissue Engineering Research, 2021, 25(31): 5053-5058.

图/表（结果） 3

参考文献

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间充质干细胞治疗骨关节炎软骨损伤：作用、应用与问题

Mesenchymal stem cells in the treatment of cartilage damage in osteoarthritis: role, application, and problem

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