中国组织工程研究

中国组织工程研究 ›› 2011, Vol. 15 ›› Issue (7): 1255-1258.doi: 10.3969/j.issn.1673-8225.2011.07.026

• 组织构建学术探讨 tissue construction academic discussion • 上一篇    下一篇

组织工程肺的细胞源及支撑架

王  磊1，陈  寅1，钟  竑1, 2   

  1. 1上海交通大学医学院新华医院心胸外科，上海市 200092
    2上海交通大学医学院新华医院(崇明)心胸外科，上海市202150
  • 收稿日期:2010-07-28 修回日期:2010-09-02 出版日期:2011-02-12 发布日期:2011-02-12
  • 通讯作者: 钟竑，博士，教授，主任医师，硕士生导师，上海交通大学医学院新华医院心胸外科，上海市 200092；上海交通大学医学院新华医院(崇明)心胸外科，上海市202150 zhonghongyyy@163.com
  • 作者简介:王磊★，男，1983年生，江苏省赣榆县人，汉族，上海交通大学医学院在读硕士，医师，主要从事干细胞与胸部疾病的研究。 wllygjs@126. com

Cell source and support scaffolding of tissue-engineered lung

Wang Lei1, Chen Yin1, Zhong Hong1,2   

  1. 1Department of Thoracic and Cardiovascular Surgery, Xinhua Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai  200092, China
    2Department of Thoracic and Cardiovascular Surgery, Xinhua Hospital (Chongming), School of Medicine, Shanghai Jiao Tong University, Shanghai  202150, China
  • Received:2010-07-28 Revised:2010-09-02 Online:2011-02-12 Published:2011-02-12
  • Contact: Zhong Hong, Doctor, Professor, Chief physician, Master’s supervisor, Department of Thoracic and Cardiovascular Surgery, Xinhua Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200092, China; Department of Thoracic and Cardiovascular Surgery, Xinhua Hospital (Chongming), School of Medicine, Shanghai Jiao Tong University, Shanghai 202150, China zhonghongyyy@163.com
  • About author:Wang Lei★, Studying for master’s degree, Physician, Department of Thoracic and Cardiovascular Surgery, Xinhua Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200092, China wllygjs@126.com

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摘要：

背景：虽然组织工程肺组织研究进展缓慢，但是应用干细胞或祖细胞及相关支撑架在一定条件下培育出功能健全的可用来替换的肺组织，有望为许多肺部疾患的肺移植治疗提供供体。
目的：综述组织工程肺研究中肺的细胞源及支撑架的研究进展。
方法：应用计算机检索中国期刊全文数据库和PubMed数据库(1990-01/2009-01)相关文献，检索词分别为：“组织工程肺；细胞源；支撑架”和“tissue-engineered lung；cell source；support scaffolding”，语言分别设定为中文和英文，共检索到89篇文章，阅读文题和摘要进行筛选，选择具有原创性，论点论据可靠且分析全面的组织工程肺细胞源及支撑架密切相关文章，排除重复性研究以及质量较差文章，最后纳入33篇进行总结综述。
结果与结论：由于肺组织结构复杂、再生能力有限，肺疾病的治疗已成为棘手的问题。目前认为组织工程可培育出功能健全的可用来替换的肺组织。这是一种很有前途的治疗手段，但目前尚处于研究的初级阶段。相信随着组织工程肺的细胞源及支撑架研究的深入，会有更多的新发现，组织工程肺研究在临床应用上具有广阔的前景。

关键词: 组织工程肺, 细胞源, 支撑架, 肺移植, 研究进展, 综述文献

Abstract:

BACKGROUND: Although there was slow progress in the engineering of the lung, new functional replacement lung tissue can be generated through tissue engineering in the use of stem or progenitor cells and related support scaffolding under certain condition. The research about the cell source and support scaffolding of a tissue-engineered lung has gained homologous progress.
OBJECTIVE: To review recent advance on the development of cell source and support scaffolding in the tissue-engineered lung research.
METHODS: A computer-based online search of China Journal Full-text Database and PubMed was performed for articles and reviews in Chinese and English from January 1990 to January 2009. The key words were “tissue-engineered lung, cell source, support scaffolding”. A total of 89 articles were retrieved, and screened following reading titles and abstracts. Literatures about cell source and support scaffolding in the tissue-engineered lung research were included. Repetitive articles with poor quality were excluded. Finally, 33 literatures were included.
RESULTS AND CONCLUTION: Because lung tissues have a complex three-dimensional structure and little capacity of regeneration, it is difficult to cure for lung diseases. At present, it is known that the new functional replacement lung tissue can be generated through tissue engineering. This is a promised therapeutic tool, but it still is the basal research stage. With the development of the cell source and support scaffolding of a tissue-engineered lung, there will be more and more new discovery. Tissue-engineered lung research will have a broad prospect in the clinical application.

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