中国组织工程研究

中国组织工程研究 ›› 2011, Vol. 15 ›› Issue (48): 9116-9120.doi: 10.3969/j.issn.1673-8225.2011.48.047

• 骨与关节临床实践 clinical practice of the bone and joint • 上一篇    

快速进展型股骨头坏死患者血清骨代谢生化指标的变化

梅  杰1，彭  昊1，尹  东2   

  1. 1武汉大学人民医院骨科，湖北省武汉市  430060
    2广西壮族自治区人民医院骨科，广西壮族自治区南宁市  530021
  • 收稿日期:2011-06-14 修回日期:2011-09-01 出版日期:2011-11-26 发布日期:2011-11-26
  • 通讯作者: 彭昊，博士，教授，博士生导师，武汉大学人民医院骨科，湖北省武汉市430060 penghao5868@163.com 并列通讯作者：尹东，博士，主任医师，硕士生导师，广西壮族自治区人民医院骨科，广西壮族自治区南宁市 530021 tangin2002@163.com
  • 作者简介:梅杰★，男，1984年生，浙江省丽水市人，汉族，武汉大学在读硕士，主要从事股骨头坏死的基础与临床研究。 meijie302@yahoo.com.cn

Variation in serum biomarkers of bone turnover in rapidly progressive necrosis of the femoral head

Mei Jie1, Peng Hao1, Yin Dong2   

  1. 1Department of Orthopedics, Renmin Hospital of Wuhan University, Wuhan  430060, Hubei Province, China
    2Department of Orthopedics, People’s Hospital of Guangxi Zhuang Autonomous Region, Nanning  530021, Guangxi Zhuang Autonomous Region, China
  • Received:2011-06-14 Revised:2011-09-01 Online:2011-11-26 Published:2011-11-26
  • Contact: Peng Hao, Doctor, Professor, Doctoral supervisor, Department of Orthopedics, Renmin Hospital of Wuhan University, Wuhan 430060, Hubei Province, China penghao5868@163.com Correspondence to: Yin Dong, Doctor, Chief physician, Master’s supervisor, Department of Orthopedics, People’s Hospital of Guangxi Zhuang Autonomous Region, Nanning 530021, Guangxi Zhuang Autonomous Region, China tangin2002@163.com
  • About author:Mei Jie★, Studying for master’s degree, Department of Orthopedics, Renmin Hospital of Wuhan University, Wuhan 430060, Hubei Province, China meijie302@yahoo.com.cn

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470

被引次数

10

摘要：

背景：国外研究认为快速进展型股骨头坏死的发病机制为血清关节软骨代谢及破骨细胞功能的异常。
目的：检测快速进展型股骨头坏死患者血清中骨生化标志物TRACP-5b及CTX-Ⅱ的表达。
方法：利用酶联免疫吸附试剂盒检测普通股骨头坏死患者(n=30，普通组)、快速进展型股骨头坏死患者(n=30，快速进展组)、骨质疏松症患者(n=30，骨质疏松组)、对照患者(n=30，单纯外伤后软组织缺损或单纯腘窝囊肿患者)血清中TRACP-5b及CTX-Ⅱ水平。
结果与结论：快速进展组、骨质疏松组TRACP-5b水平高于普通组、对照组(P < 0.05)，普通组TRACP-5b水平稍高于对照组，但差异无显著性意义(P > 0.05)。快速进展组CTX-Ⅱ水平高于其他3组(P < 0.05)，普通组、骨质疏松组CTX-Ⅱ水平稍高于对照组，但差异无显著性意义(P > 0.05)。说明：①快速进展型股骨头坏死的可能病理机制之一为TRACP-5b水平上升，破骨细胞活性增强，CTX-Ⅱ水平上升，关节软骨降解过快。②TRACP-5b及CTX-Ⅱ有可能成为诊断快速进展型股骨头坏死的指标之一。

关键词: 股骨头坏死, 病因, 酶联免疫吸附实验, 骨代谢生化指标, TRACP-5b, CTX-Ⅱ

Abstract:

BACKGROUND: Foreign studies have suggested that the pathogenesis of rapidly progressive necrosis of the femoral head is associated with abnormal serum metabolism of articular cartilage and osteoclast dysfunction.
OBJECTIVE: To determine the expression of TRACP-5b and CTX-Ⅱ in serum of patients with rapidly progressive necrosis of the femoral head.
METHODS: Enzyme-linked immunosorbent assay kit was used to detect the expression of TRACP-5b and CTX-Ⅱ in serum of patients with common femoral head necrosis (group A, n=30), patients with rapidly progressive femoral head necrosis (group B, n=30), patients with osteoporosis (group C, n=30), and patients with Soft tissue defect or simply popliteal cyst (group D, n=30).
RESULTS AND CONCLUSION: The expressions of TRACP-5b in the groups B and C were higher than those in the groups A and D (P < 0.05); while the expression of TRACP-5b was slightly higher in the group C than the group D without significant difference (P >0.05). The expressions of CTX-Ⅱ was the highest in the group B (P < 0.05), and slightly higher in the groups A, C than group D without significant difference (P > 0.05). It is indicated that one of the possible pathological mechanisms of the rapidly progressive necrosis of the femoral head is the enhance activity of osteoclasts leading to the elevated expression of serum TRACP-5b and rapid articular cartilage degradation leading to the elevated expression of serum CTX-Ⅱ. The candidate diagnostic criteria for the rapidly progressive necrosis of the femoral head may be the TRACP-5b and CTX-Ⅱ in the future.

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