中国组织工程研究 ›› 2010, Vol. 14 ›› Issue (51): 9627-9630.doi: 10.3969/j.issn.1673-8225.2010.51.029

• 生物材料学术探讨 biomaterial academic discussion • 上一篇    下一篇

气管支气管内支架材料的评价

薛运昕,肖  静   

  1. 辽宁省金秋医院呼吸科,辽宁省沈阳市  110016
  • 出版日期:2010-12-17 发布日期:2010-12-17
  • 作者简介:薛运昕★,女,1971年生,辽宁省沈阳市人,汉族,1995年中国医科大学毕业,硕士,副主任医师,主要从事呼吸内科的研究。 cmuxyxdd@sohu.com

Evaluation of tracheobronchial stent materials

Xue Yun-xin, Xiao Jing   

  1. Department of Respiratory Medicine, Autumn Hospital in Liaoning Province, Shenyang   110016, Liaoning Province, China
  • Online:2010-12-17 Published:2010-12-17
  • About author:Xue Yun-xin★, Master, Associate chief physician, Department of Respiratory Medicine, Autumn Hospital in Liaoning Province, Shenyang 110016, Liaoning Province, China cmuxyxdd@sohu.com

摘要:

目的:评价各种气管支气管支架材料的性能和应用,寻找更加安全有效的气管内支架材料。
方法:以“人工气管,气管支架,生物材料”为中文关键词,“trachus,bronchus,stent”为英文关键词,由第一作者应用计算机检索Pubmed 数据库(http://www.ncbi.nlm.nih.gov/PubMed)及维普数据库(http://www.cqvip.com/) 1995-01/ 2008-10有关气管支架生物材料的文献,排除重复研究或Meta分析类文章。以18篇文献为主重点讨论了气管支气管支架材料的种类及其性能。
结果:经检索共查到相关文献50余篇,经阅读标题、摘要、全文后筛选纳入18篇文献进行评价。其中英文文献16篇,中文文献2篇。各种材料的气管支架均有其特点,不能完全否定任何一种材质的支架。文献显示目前国内应用最多的为镍钛记忆合金支架,它已被广泛应用于各类原因所致的气管狭窄治疗中,可以被径向拉长,此时直径变细,便于装入导管。释放后又可以自动回复至原直径,顺应性良好,可置于气管各个部位,很好地缓解了气短症状,从而减轻患者的痛苦。
结论:人工气管支架近年来发展迅速,金属类支架更是得到了蓬勃的发展。其中镍钛记忆合金支架是目前较为理想的支架材料,它既安全可靠,操作方便又价格适宜,已被广泛地应用于各类气管狭窄的治疗中。

关键词: 人工气管, 生物材料, 气管支架, 镍钛记忆合金, 顺应性

Abstract:

OBJECTIVE: To evaluate the performance and application of tracheobronchial stent materials, to find a more safe and effective tracheal stent materials.
METHODS: Using “artificial airway, tracheal stent, biological material” in Chinese and “trachus, bronchus, stent” in English as the key words, a computer-based online search of Pubmed database (http://www.ncbi.nlm .nih.gov/PubMed) and the VIP database (http://www.cqvip.com/) from January 1995 to October 2008 was performed by the first author for articles about tracheal stent biomaterials, repeated study or Meta analysis were excluded. Eighteen articles mainly focused on the types and properties of tracheobronchial stent materials.
RESULTS: A total of more than 50 articles were screened out, 18 of them were involved in the evaluation after reading the title, abstract and full text, including 16 English literatures and 12 Chinese literatures. Various materials for tracheal stent have their characteristics, and cannot be completely denied. Nickel-titanium shape memory alloy stent is most used in China, which has been widely used for the treatment of airway stenosis due to various reasons, can be radially stretched, at this time the diameter becomes thinner and easy to load into catheter. After release, it automatically return to the original diameter, indicating a good compliance, and can be placed in various parts of the airway, better relieve short breath symptoms, so as to reduce the suffering of patients.
CONCLUSION: In recent years, artificial tracheal stents are rapidly developing, and metal stents even more. Nickel-titanium shape memory alloy stent is the ideal scaffold material, it is safe, reliable, easy to operate and affordable, has been widely used in treatment of various types of airway stenosis.

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