关键词: 肾虚模型, 肾阳虚, 肾阴虚, 动物模型, 中医, 激素水平, 靶腺轴, 肾虚指标

Abstract:

BACKGROUND: There are many kinds of diseases invasion relating to renal deficiency, animal models of renal deficiency usually play important role in the experimental researches of these diseases. It will provide a great help to the research by selecting a suitable way to make the model.
OBJECTIVE: To summarize the methods, theories and types of making model, and to analyze the test methods and significance of indexes.
METHODS: Journals, conference papers and reviews about kidney deficient model published between 2004 and 2009 were searched from CNKI and WANFANG databases. The related references were supplemented to analyze the model preparation methods and detective measures.
RESULTS AND CONCLUSION: In total 46 papers were selected. The method consists of drug intervention, surgical resection and simulating the pathogenesis and etiological factor of the traditional Chinese medicine. The model mainly consists of deficiency of kidney-yin and deficiency of kidney-yang. The data which reflected the changes in the systems of animal's endocrine, immune and reproductive were mainly detected by naked eyes, microscopes, measuring and biochemistry, and then confirmed whether the model consist with the pathogenesis of renal deficiency of the traditional Chinese medicine. There is an increasing tendency to research the DNA, RNA and protein variance of the model, but no index served as “golden index”. It is not acceptable which material contribute to renal deficiency.