中国组织工程研究 ›› 2017, Vol. 21 ›› Issue (2): 303-308.doi: 10.3969/j.issn.2095-4344.2017.02.025

• 生物材料综述 biomaterial review • 上一篇    下一篇

载药系统中的静电纺丝材料及其应用

赵治锋1,杨之洵1,李  峰1,木沙-哈木山1,史一帆1,费  健2,张  俊2,崔文国3
  

  1. 上海交通大学医学院附属瑞金医院,1临床医学院,2普外科,上海市  200025;3苏州大学骨科研究所,江苏省苏州市  215006
  • 收稿日期:2016-10-31 出版日期:2017-01-18 发布日期:2017-02-27
  • 通讯作者: 费健,副主任医师,博士,上海交通大学医学院附属瑞金医院,上海市 200025
  • 作者简介:赵治锋,男,1994年生,山西省长治市人,汉族。
  • 基金资助:

    上海市医务工会“星光计划”优秀(资助)项目(2014年),课题负责人:费健

Electrospun materials applied in drug delivery system

Zhao Zhi-feng1, Yang Zhi-xun1, Li Feng1, Musha Hamushan1, Shi Yi-fan1, Fei Jian2, Zhang Jun2, Cui Wen-guo3 
  

  1. 1School of Clinical Medicine, 2Department of General Surgery, Ruijin Hospital, Shanghai Jiao Tong University, Shanghai 200025, China; 3Institute of Orthopaedics, Soochow University, Suzhou 215006, Jiangsu Province, China
  • Received:2016-10-31 Online:2017-01-18 Published:2017-02-27
  • Contact: Fei Jian, M.D., Associate chief physician, Department of General Surgery, Ruijin Hospital, Shanghai Jiao Tong University, Shanghai 200025, China
  • About author:Zhao Zhi-feng, School of Clinical Medicine, Ruijin Hospital, Shanghai Jiao Tong University, Shanghai 200025, China
  • Supported by:

    the “Star Plan” Excellent Project of Shanghai Medical Union in 2014

摘要:

文章快速阅读:

 

文题释义:
静电纺丝
:以电流体动力学为基础合成纤维,多聚物溶液在强电场带电后,电场力克服液体表面张力,使针头液滴变为圆锥形“泰勒锥”,从毛细喷管口喷出,发射到接收板并聚集成丝。药物则通过溶解弥散于多聚物溶液后,以纤维包埋形式合成。
静电纺丝材料:分为天然产物、合成高分子及混纺材料。天然产物包括胶原、蚕丝蛋白、透明质酸等。合成材料包括聚乳酸,聚己内酯等。混纺材料包括聚乳酸-羟基乙酸共聚物等。此外材料按是否可自然降解又分为2种,其中可降解材料的药物释放不稳定且构型复杂,但免于二次手术取出,长期负面影响更小,故而更受欢迎。需要注意的是,可降解材料释药须参考降解速率及固有释药速率进行调整后方可。

背景:近些年来,静电纺丝材料正在临床载药领域得到越来越广泛的应用。
目的:综述静电纺丝材料在载药系统中的应用及其前景。
方法:以“Electrospinning, drug delivery system, nanofibers, electrospun materials”为关键词,检索PubMed、NCBI数据库中近10年来关于载药电纺支架在组织工程、肿瘤化疗等临床应用领域的最新进展。
结果与结论:与传统材料相比,静电纺丝支架具有良好的多样性及参数高可控性,在针对不同组织生理条件下的个性化应用具有独到优势。目前相关载药材料主要由天然产物、合成高分子材料及混纺材料等构成,搭载药物主要包括抗生素、化疗药、蛋白质及DNA等。静电纺丝材料在临床主要应用于组织工程、肿瘤化疗、创面愈合等领域,如何实现药物在多聚物溶液中的稳定均一扩散的同时保证高载药率及低药物流失是最终的目标。相信电纺材料以其固有优势配合多样化的载药方案,必将在这一交叉学科中获得更大的发展。

关键词: 生物材料, 材料相容性, 静电纺丝, 载药系统, 电纺材料, 综述

Abstract:

BACKGROUND: Recently, electrospun materials have been extensively applied in the drug delivery system.
OBJECTIVE: To overview the application prospect of electrospun materials in drug delivery systems.
METHODS: A computer-based search of PubMed and NCBI databases was performed for literatures about the research progress of electrospinning in tissue engineering and chemotherapy published within the past 10 years using the keywords of “electrospinning, drug delivery system, nanofibers, electrospun materials”.
RESULTS AND CONCLUSION: Compared with traditional materials, electrospun stents hold good versatility and controllable parameters, thus granting its unique advantage under various physiological conditions. Current drug-loaded materials composed of natural products, synthetic polymers and blended materials; as to drugs, there are antibiotics, chemotherapy medication, DNA and protein. Electrospun materials have been used in tissue engineering, cancer chemotherapy and wound healing. We focus on not only the application progress of electrospun materials in traditional treatments, but also its usage, condition-controlled drug release and living-cell carrying. Electrospun materials combined with various drug-loaded present a broad prospect.

Key words: Delayed-Action preparations, Review, Tissue Engineering

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